abstract

Question 1

IOP

Answer 1

intraocular pressure

Question 2

Which function the CB has?

Answer 2

Secretes aqueous humor that maintains intraocular pressure

Question 3

What does NOTCH signaling in the CB maintains and regulates?

Answer 3

CB morphogenesis,
aqueous humor secretion,
and vitreous protein expression

Question 4

Which protein, controlled by NOTCH 2 and 3 regulates ICE-OCE adhesion
CB morphogenesis aqueous humor
secretion
protein expression

Answer 4

RBPJ

Question 5

OEC

Answer 5

Outer ciliary body

Question 6

IEC

Answer 6

Inner ciliary body

Question 7

Which nectin expression the notch controls and where?

Answer 7

Nectin 1 in the outer ciliary epithelium

Question 8

Which protein is stabilized by notch for controlling aqueous humor secretion (at the end point)

Answer 8

Cx43

Question 9

Cx43

Answer 9

Conditional inactivation of connexin43

Question 10

Connexin43 ?

Answer 10

gap junctions components, providing direct links between cells under many physiological processes

Question 11

other from his structural roles, connexin is also found to be

Answer 11

transcriptional regulator

Question 12

what function in the eye does the Cx43 control

Answer 12

aqueous humor secretion

Question 13

ASD

Answer 13

anterior segment

dysgenesis

Question 14

what are the three major components of the ciliary body?

Answer 14

nonpigmented inner ciliary epithelium (ICE)
pigmented outer ciliary epithelium (OCE)
underlying stroma and blood vessels

Question 15

what are the two important biological

functions of the CB?

Answer 15

lens accommodation and production of aqueous and

vitreous humor

Question 16

which component of the eyeball generates the IOP?

Answer 16

aqueous and vitreous humor

Question 17

Who is nourished by the aqueous humor ?

Answer 17

avascular anterior structures

Question 18

Which eye condition be caused by elevated IOP?

Answer 18

glaucoma

Question 19

what is glaucoma?

Answer 19

eye condition where the optic nerve, which connects the eye to the brain, becomes damaged

Question 20

which part of the CB control the lens accommodation?

Answer 20

Zonule fibers

Question 21

what is the Zonule of Zinn? (zonule fiber)

Answer 21

ring of fibrous strands forming a zonule (little band) that connects the ciliary body with the crystalline lens of the eye

Question 22

which diseases can be caused by defects in the lens contraction process?

Answer 22

myopia (nearsightedness)

Question 23

What is the main condition in myopia?

Answer 23

vision condition in which you can see objects near to you clearly, but objects farther away are blurry

Question 24

What does the ciliary body controls?

Answer 24

extracellular
matrix (ECM) proteins,
growth factors, 
and other proteins into
the anterior chamber

Question 25

from which areas the CB develops?

Answer 25

from the ciliary marginal zone (CMZ) at the | rim of the optic cup

Question 26

which type of signaling controls the patterning of the presumptive CB region?

Answer 26

FGF signaling (fibroblast growth factor)

Question 27

which signaling is required for CB specification?

Answer 27

Wnt signaling

Question 28

which type of nectin is expressed on IEC

Answer 28

Nectin 3

Question 29

which type of nectin is expressed on OEC

Answer 29

Nectin 1

Question 30

what is JAG1's gene role?

Answer 30

activaion of notch pathway

Question 31

which NOTCH receptor together with JAG regulates CB formation?

Answer 31

NOTCH 2

Question 32

which mutant showed more defected phenotype, notch or RBPJ ?

Answer 32

RBPJ mutants

Question 33

Through which protein, notch 2 and 3 regulate CB morphogenesis?

Answer 33

Nectin 1

Question 34

to whom the CB provide nutriative support?

Answer 34

the cornea the lens the trabecular meshwork the retina

Question 35

through which channel protein the CB controls humor secretion?

Answer 35

TRPV4 (Transient receptor potential vanilloid-type 4)

Question 36

what does the dependence on the TRPV4 channel suggests, regarding to the IOP

Answer 36

that the IOP modulate the secretion of the humor

Question 37

which type of proteins the Human and mouse CBs can secrete into the vitreous?

Answer 37

collagen and Opticin

Question 38

What is the Opticin protein?

Answer 38

associated with the extracellular matrix. present in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. bind collagen fibrils and regulate fibril morphology, spacing, and organization

Question 39

According to this study, what is controlled through nectin1 on the OCE by notch signaling?

Answer 39

- humor secretion - morphogenesis - aqueous protein expression in the ICE