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Papers - NOTCH Signaling Controls Ciliary Body Morphogenesis and Secretion by Directly Regulating Nectin Protein Expression > abstract > Flashcards

abstract Flashcards

1
Q

IOP

A

intraocular pressure

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2
Q

Which function the CB has?

A

Secretes aqueous humor that maintains intraocular pressure

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3
Q

What does NOTCH signaling in the CB maintains and regulates?

A

CB morphogenesis,
aqueous humor secretion,
and vitreous protein expression

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4
Q

Which protein, controlled by NOTCH 2 and 3 regulates ICE-OCE adhesion
CB morphogenesis aqueous humor
secretion
protein expression

A

RBPJ

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5
Q

OEC

A

Outer ciliary body

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6
Q

IEC

A

Inner ciliary body

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7
Q

Which nectin expression the notch controls and where?

A

Nectin 1 in the outer ciliary epithelium

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8
Q

Which protein is stabilized by notch for controlling aqueous humor secretion (at the end point)

A

Cx43

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9
Q

Cx43

A

Conditional inactivation of connexin43

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10
Q

Connexin43 ?

A

gap junctions components, providing direct links between cells under many physiological processes

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11
Q

other from his structural roles, connexin is also found to be

A

transcriptional regulator

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12
Q

what function in the eye does the Cx43 control

A

aqueous humor secretion

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13
Q

ASD

A

anterior segment

dysgenesis

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14
Q

what are the three major components of the ciliary body?

A

nonpigmented inner ciliary epithelium (ICE)
pigmented outer ciliary epithelium (OCE)
underlying stroma and blood vessels

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15
Q

what are the two important biological

functions of the CB?

A

lens accommodation and production of aqueous and

vitreous humor

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16
Q

which component of the eyeball generates the IOP?

A

aqueous and vitreous humor

17
Q

Who is nourished by the aqueous humor ?

A

avascular anterior structures

18
Q

Which eye condition be caused by elevated IOP?

A

glaucoma

19
Q

what is glaucoma?

A

eye condition where the optic nerve, which connects the eye to the brain, becomes damaged

20
Q

which part of the CB control the lens accommodation?

A

Zonule fibers

21
Q

what is the Zonule of Zinn? (zonule fiber)

A

ring of fibrous strands forming a zonule (little band) that connects the ciliary body with the crystalline lens of the eye

22
Q

which diseases can be caused by defects in the lens contraction process?

A

myopia (nearsightedness)

23
Q

What is the main condition in myopia?

A

vision condition in which you can see objects near to you clearly, but objects farther away are blurry

24
Q

What does the ciliary body controls?

A 
extracellular
matrix (ECM) proteins,
growth factors, 
and other proteins into
the anterior chamber
25
Q

from which areas the CB develops?

A

from the ciliary marginal zone (CMZ) at the

rim of the optic cup

26
Q

which type of signaling controls the patterning of the presumptive CB region?

A

FGF signaling (fibroblast growth factor)

27
Q

which signaling is required for CB specification?

A

Wnt signaling

28
Q

which type of nectin is expressed on IEC

A

Nectin 3

29
Q

which type of nectin is expressed on OEC

A

Nectin 1

30
Q

what is JAG1’s gene role?

A

activaion of notch pathway

31
Q

which NOTCH receptor together with JAG regulates CB formation?

A

NOTCH 2

32
Q

which mutant showed more defected phenotype, notch or RBPJ ?

A

RBPJ mutants

33
Q

Through which protein, notch 2 and 3 regulate CB morphogenesis?

A

Nectin 1

34
Q

to whom the CB provide nutriative support?

A

the cornea
the lens
the trabecular meshwork
the retina

35
Q

through which channel protein the CB controls humor secretion?

A

TRPV4 (Transient receptor potential vanilloid-type 4)

36
Q

what does the dependence on the TRPV4 channel suggests, regarding to the IOP

A

that the IOP modulate the secretion of the humor

37
Q

which type of proteins the Human and mouse CBs can secrete into the vitreous?

A

collagen and Opticin

38
Q

What is the Opticin protein?

A

associated with the extracellular matrix. present in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. bind collagen fibrils and regulate fibril morphology, spacing, and organization

39
Q

According to this study, what is controlled through nectin1 on the OCE by notch signaling?

A
  • humor secretion
  • morphogenesis
  • aqueous protein expression in the ICE

Papers - NOTCH Signaling Controls Ciliary Body Morphogenesis and Secretion by Directly Regulating Nectin Protein Expression (2 decks)

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