ABSITE QUEST Flashcards
What would a FDR need to have to warrant your screening at age 40 vs age of onset in FDR (whichever is earlier)?
advanced adenoma (high-grade dysplasia, >/= 1 cm, villous or TV histology, traditional serrated adenoma)
OR
advanced sessile serrated polyp (>/= 1 cm, any dysplasia)
most likely injured vessel during ALIF (esp L5-S1)
left common iliac vein
best imaging for initial w/u of extremity soft tissue sarcoma?
MRI - depth and anatomic relationships
What does PCC contain?
Why not FFP?
Clotting factors 2, 7, 9, 10
FFP takes too much volume and time
Mgmt for chylous ascites?
MCFA –> bowel rest, TPN, octreotide –> surgical ligation
MAP target in septic shock?
65
what is considered cost effective per CDC?
cost of intervention <$50,000 per QALY (quality-adjusted life years gained)
What is Hinchey classification?
0: mild
IA: pericolic inflammation - phlegmon
IB: pericolic/mesocolic abscess
II: pelvic, distant intraabd or intraperitoneal abscess
III: purulent peritonitis
IV: feculent peritonitis
How does ketamine work
Noncompetitive NMDA receptor antagonist that blocks glutamine
Which nerves innervate EAS?
internal pudendal (inf rectal)
S4
In which perianal spaces can a horseshoe abscess form
ishiorectal
intersphincteric
What is the modified hanley procedure? (for horseshoe abscesses)
small incision bw tip of coccyx + anal verge
separate tissues of EAS, drain abscess
seton around sphincter complex
2 lateral counterincisions are made with setons added as well
treatment for supralevator abscess
image-guided closed suction drain placement
What type of anastomosis is avoided in pts with hx diarrhea
coloanal, low colorectal, or ileoanal anastomoses
what’s a full workup for CRC?
CEA
CT C/A/P
Cscope
what timeframe constitutes a CHRONIC anal fissure
6 wks
Ideal diet for chylous ascites?
high protein
low fat
OR TPN +/- somatostatin
describe immune infiltrate of chylous ascites
leukocytosis with lymphocytic predominance
what levels are high in carcinoid syndrome?
5-HIAA
serum chromogranin A
tx for metastatic carcinoid?
(in no order)
1. IR embo
2. surgical debulking
3. ss analogs ie lanreotide
if don’t work alone, can add a tryptophan hydroxylase inhibitor
4. chemo
which cells do carcinoid originate from?
enterochromaffin or kulchinsky cells
__ to __% of carcinoids are found in the lung
10-25%
MC tumor of appendix?
carcinoid
GIST are MC found in the ___
stomach
what do you do for mesenteric cysts?
must excise to prevent recurrence + malignancy risk
- usually don’t need SBR or resection of mesentery but ok to do if very large and compromising mesenteric vasculature
abx for pancreatic necrosis?
carbapenem alone (erta, imipenem)
quinolone/ceftaz/cefepime + metronidazole
in which case would you be ok with FLR…
<20%
<30%
<40%
- healthy liver
- hepatic fibrosis + hepatotoxic chemo
- cirrhosis
what’s assoc with seatbelt sign?
Chance fracture - horizontal fx from post to ant, involving at least 2 columns
(can have paraplegia)
what are obligate glucose users?
RBC
peripheral neurons
neutrophils
adren medulla
what’s a rare but serious complic of rubber band hemorrhoidectomy?
perianal sepsis
tx: EUA with wide debridement + drainage
what kind of org is e coli
aerobic GN rod
MC bacteria in SBP?
- e coli
- streptococcus
anaerobic = uncommon
where does medullary thyroid CA originate?
parafollicular C cells of thyroid
Rome IV criteria for IBS?
recurrent abd PAIN at least 1 day/wk in last 3 months, w/ 2+ of the following:
- related to defecation
- change in freq of stool
- change in form (appearance) of stool
*sx onset at least 6 mo prior to dx
Preop RF for anastomotic leak
male gender
higher ASA class
preop radiation
renal disease
most signif: fecal contamination
(also excess intraop blood loss, >100)
which direction does appendix go with pregnancy?
more anterior
imaging: US … MRI if US can’t see
tx: lap appy (perf appendicitis assoc with 36% chance fetal loss!)
Characteristics of ACC?
irregular, heterogenous
dia >4cm
>20 HU
<50% washout in 10 min (delay)
hypointense compared to liver on T1 MRI
in a patient with leg venous insuff / post-thrombotic syndrome … what do you do and why?
LE venogram
to assess whether venous system (particularly proximally, like iliac) is chronically diseased or stenotic … can stent to improve swelling
MC indication for hysterectomy?
symptomatic uterine fibroids
what is staining of desmoids?
beta catenin
actin
vimentin
negative for:
- cytokeratin
- S100
serum chloride:phosphate ratio should be WHAT for primary hyperPTH?
> 33
s & s of richter hernia?
tenderness + nodularity at surgical scar site … progress quickly to bowel gangrene
in setting of dehydration, what happens to the efferent (renal) arteriole?
vasoconstriction
to maintain glomerular capillary hydrostatic pressure –> maintain normal GFR
what is JGA pathway?
macula densa cells (within JGA) sense low Na –> JGA cells release renin –> activate RAAS –> increase Na + H20 reabsorption
types of fundoplication issues
normal nissen (360): could be too tight
partial: maybe not tight enough
*disrupted: recurrent symptoms (heartburn, regurgitation)
twisted: chest pain, dysphagia, poss GOO
*migrated: won’t really see it and will see hernia (hole)
*slipped: will see it + hernia (hole)
PEH: will see clearly
*likely one of these if having issues 2 months after surgery
what are the chances of siblings being HLA-identical?
25%
only NOA that can be partially removed via HD?
dabigatran
reversal for rivaroxaban? (xarelto)
andexanet alfa
mechanism of action: warfarin
prevent vit K decarboxylation of glutamic residues on vit-K dep factors
screening for FAP pts
*start CRC screening at age 12 - with flex proctosig …
+polyps –> Cscope
-polyps –> repeat q1-2 years
*start UGI tract screening at 20-25 yrs
*annual thyroid screening
women with lynch syndrome … when offer TAH BSO?
at time of colectomy, over 40 yrs, or have finished childbearing
where are carcinoids most likely found?
small intestine
rectum
appendix (if <2cm: appy alone … if >=2cm, involving base, high risk, +LVI: stage –> R hemi + LAD)
tell me about vasopressin (sorry)
V1: vasoconstriction
V2: water R
V3: release of vWf and F8
- released from post pit but made in HYPOTHAL
-ADH stimulated by hypovaolemia and hyperosmolarity
how does p53 work?
tumor suppressor protein
cells with DNA damage –> cell cycle arrest –> DNA repair OR apoptosis
how does bacitracin work
inhibits bacterial cell wall synthesis
side effects: nephrotoxicity (oliguria + edema)
allergic contact dermatitis
what lung volume decreases with morbid obesity?
*decreased in chest wall + lung compliance
- FRC (primarily due to decreased ERV)
- VC
- TLC
how do antifungals work?
amphotericin B: bind to fungal cell wall sterols –> cause lysis
azoles: inhibit fungal cell wall synthesis (critical for cell wall growth)
echinocandin (caspofungin): inhibit fungal cell wall synthesis
how does succinylcholine work?
noncompetitive neuromuscular ACh inhibitor … binds to nicotinic R and causes depol
which is LESS likely to strangulate? direct or indirect hernia
direct hernia - wider neck
odontoid fx (C2)
type 1: upper part of dens - stable
type 2: base of dens - unstable
type 3: extend into C2 vert body - rarely need surgery
surgical procedure for slow transit constipation?
TAC with iliorectal anastomosis
(50-100% success for increasing stool frequency)
causes of acute lower GI bleeding?
Anatomic (diverticulosis)
Inflammatory (IBD)
Neoplastic
Vascular (angiodysplasia, radiation-induced, ischemia)
Iatrogenic (polypectomy)
diverticulosis in high risk pt (persistent bleeding, old, anemia, elevated BUN) … what do you do?
resuscitate –> bowel prep + Cscope asap (within 24 hr)
what is the pathophysiology that can lead to rapid death in open ptx?
collapsed lung 2/2 exposure to atmospheric air, causing severe alteratino of ventilation and venoarterial shuting (V/Q imbalance, respiratory distress)
tell me about ischemic orchitis after inguinal hernia surgery
- presents POD 2-5 (can last up to 12 wks)
- ESP during surgery for RECURRENT inguinal hernia
- thrombosis of pampiniform plexus»_space;> ligation of testicular artery
- tx: anti-inflammatories (NSAIDs) + analgesics (ing nerve block for pain)
*seldom need orchiectomy
*do not re-explore
*do no I&D
changes with alk or acidosis with breathing
hyperventilation –> hypoCO2 –> resp alkalosis
hypoventilation –> too much CO2 –> resp acidosis
what is chronic inguinodynia
postop pain >3 mo after ing hernia repair
tx:
1) PT + oral p meds
2) nerve block
3) respond to block but then have recurrent pain –> triple neurectomy (also remove tacks/mesh after lap surgery ; remove old mesh and replace in preperitoneal space after open surgery)
where are the inguinal nerves located
iliohypogastric: (lies on ant surface of quadratus lumborum and traverses iliacus) between ext and int oblique
ilioinguinal: (traverses the iliacus) over the spermatic cord
fem branch of gf nerve: (more medial course) underside of spermatic cord structures
how is protamine dosed?
1mg for every 100u heparin pt received (half life of heparin is 60-90 min, so also depends on time since heparin was dosed)
can everyone get protamine?
it’s a component of insulin, so diabetics using NPH or insulin aspart protamine may have sensitivity
what meds can cause histamine release?
muscle relaxants
opioids + ketamine
abx (cipro, rifaximin)
preferred method of ureteral repair
- debride tissue
- sptatulated anastomosis with interrupted absorbable sutures
- double J stent
- cover with vitalized tissue when possible
- foley
what decreases risk of electromagnetic interference in pts with implantable cardiac devices?
*ultrasonic devices
- cutting mode
- bipolar > monopolar
where does indirect inguinal hernia sac lie, relative to spermatic cord?
anterior and medial
what are alkylating agents
oxaliplatin
carboplatin
cyclophosphamide
what kind of testicular tumor has elevated AFP?
NONseminomatous
indications for STAT C section
- mother in cardiac arrest
- placental abruption (+/- vag bleeding, +pain)
- nonreassuring fetal HR (severe bradycardia 70-80 or sinusoidal pattern)
normal distance bw rectus muscles
1-2cm
pharmacologic intervention for dumping syndrome?
- acarbose (slows carb digestion)
- octreotide
primary lymphoid organs (generate lymphocytes)
secondary lymphoid organs (initiate adaptive immune response)
liver, bone, thymus
LN, spleen, tonsils, adenoids, Peyer patches
Factor 9 deficiency … what product can you give?
FFP (not Factor 9 concentrate)
Relative CI to PD catheter
peritoneal scarring
physical/psych impairment
anuria
large pt size
active inflamm process
surgical ostomies
VP shunt
lg abd wall hernia
best way to fix an abd wall hernia in setting of peritoneal dialysis plan?
extraperitoneal mesh repair at time of PD catheter placement
what can cause intussusception after IgA vasculitis?
Henoch Schonlein purpura
small bowel wall hematoma
usually ileo-ileal intussusception (vs usual ileocolic)
MCC mortality in cardiac transplant pts after 1 year?
atherosclerosis