absite killer plus - Sheet1 Flashcards
What is the source of fever in atelectasis?
Alveolar macrophages
What is the first sign of malignant hyperthermia?
Increase in end-tidal CO2
What is the treatment for malignant hyperthermia
Dantrolene
What is the first muscle to recover from paralytics?
Diaphragm
What is the rate-limiting step in cholesterol formation?
HMG coA Reductase
Where is angiotensin I converted into angiotensin II?
lung
What are the effects of angiotensin II?
Vasoconstriction Increases aldosterone (keeps Na, loses K/H in urine)
Describe the anatomy of the vagus innervation of the stomach
Left vagus (anterior) gives hepatic branch, Right (posterior) gives celiac branch and “criminal nerve of Grassi”
Which cells produce pepsinogen?
Chief cells
Which cells produce intrinsic factor?
Parietal cells
What are the main stimuli for H+ production in the stomach?
Acetylcholine, gastrin, and histamine
What is the mechanism of omeprazole?
Blocks H/K ATPase of parietal cell
What is the most common symptom post-vagotomy?
Diarrhea (35%)
What is the cause of early (15-30 min) dumping syndrome?
Hyperosmotic load, fluid shift causes neuroendocrine response, peripheral and splanchnic vasodilation
What is the cause of late (2-3 hrs) dumping syndrome?
Increased insulin with decreased glucose
What are the 3 actions of CCK?
1) contract gallbladder 2) Relax Sphincter of Oddi 3) Increase pancreatic enzyme secretion
What is the primary stimulus of pancreatic bicarb secretion?
secretin
What affects the amount of bicarb in pancreatic secretions?
Flow rate: high flow = high bicarb, low Cl. Slow flow allows more HCO3/Cl exchange
Describe the phases of the migratory motor complex
Phase I - quiescence; Phase II - acceleration, gallbladder contraction; Phase III - peristalsis; Phase IV - subsiding electric activity; occurs in 90 min cycles
What is the key stimulatory hormone of the MMC?
motilin
What drug stimulates motilin receptors?
Erythromycin
What is the action of Protein C and Protein S?
Protein C degrades active V and VIII. Protein S helps protein C
What is the only clotting factor not made in the liver?
Factor VIII (made by reticuloendothelial system)
What is the difference between the three types of Von Willebrand’s Disease?
Type I and III have low amounts of vWF, respond to ddAVP Type II is qualitatively poor vWF