Abnormalities of haemostasis Flashcards
For how long does epistaxis have to not be stopped to be a positive history for coagulopathy?
10 mins
What are the 2 categories of cause of coagulopathy?
Lack of a specific factor
Dysfunctional factor
What is thrombocytopenia a defect of?
PRIMARY haemostasis
Recall causes of bone marrow failure
Leukaemia
B12 deficiency
Recall 2 causes of accelerated clearance of platelets
Immune
DIC
Recall 5 possible causes of thrombocytopenia
Increased clearance Bone marrow failure Failure of production by megakaryocytes Shortened t1/2 Splenic sequestration
What is Glanzmann’s thrombasthania a disease of?
Glycoprotein absence
What is Bernard Soulier syndrome a disease of?
Glycoprotein absence
Recall 2 drugs that can impair platelet function
Aspirin
Clopidogrel
How many types of vWF disease are there? Recall the inheritance patterns of each
3
1 + 2 = autosomal dominant
3 = autosomal recessive
Name a congenital vessel wall disorder
Hereditary haemorrhagic telangiectasia Ehlers-Danlos syndrome
What is haemophilia a disorder of?
Secondary haemostasis
Why does DIC lead to defective secondary haemostasis?
High TF concentration –> increased consumption of factors
Describe the differences between platelet and coagulation disorders
Platelet: superficial and immediate bleeding
Coagulation: deep and delayed bleeding
Recall 4 things that may be given to replace factors in coagulopathy
- Plasma (all factors)
- Cryoprecipitate (fibrinogen, F8+9 and vWF)
- Pooled platelet concentration
- Concentrate of a specific factor
