Abnormal Cervical Cytology Flashcards
HPV associated with squamous cell carcinoma
16
Hpv assoc with adenocarcinoma
18
No new viral particles are produced
Latent phase
Dna replication
Cytopathic effect + koilocytosis
Productive phase
Precancerous lesion of squamous cell carcinoma
CIN / SIL
Assoc with productive hpv infection
Most regress
CIN 1
Low grade squamous intraepithelial lesion
Progressive deregulation of cell cycle by hpv
High grade sil
Suggestive of low grade sil
Atypical squamous cell of undetermined significance (ASC-US)
Suggestive of high grade Sil
Atypical squamous cells cannot exceed HIL
Common malignant tumor of cervix
Invasive squamous cell carcinoma
Immediate precursor of invasive squamous cell carcinoma
HSIL
Adenocarcinoma in situ or CGIN
Endocervical carcinoma
Main symptom is abnormal vaginal bleeding
Invasive endocervical adenocarcinoma
Absence of atypical or abnormal cells
Class I
Cells strong suggestive to malignancy
Class IV