Abbas Ch. 1 Flashcards
What is characteristic of the innate immune system’s specificity?
Recognition/specificity is limited to molecules shared by groups of related microbes and molecules produced by damaged host cells
Can innate cells recognise a diverse array of molecules?
Not so much, recognition molecules (receptors, complement, etc) is encoded by inherited genes. Furthermore, innate cells do not have receptors that undergo somatic hypermutation
Do innate cells have memory?
Evidence is beginning to suggest that there is some memory in innate immune cells, although it is unknown how much memory formation there is
Which cellular and chemical barriers belong to innate immunity?
Skin, mucosal epithelia, antimicrobial molecules
Which secreted proteins belong to innate immunity?
Complement proteins, various lectins, antimicrobial peptides(?)
Which cells belong to innate immunity?
Macrophages, neutrophils, dendritic cells, natural killer cells, mast cells, innate lymphoid cells, eosinophils, basophils, natural killer T cells
What is characteristic of the adaptive immune system’s specificity?
The receptors can recognise many different microbial and nonmicrobial antigens. VERY specific.
Can adaptive cells recognise a diverse array of molecules?
Yes. The diveristy of the receptors is incredibly high. Antigen receptors are generated by somatic recombination of gene segments in lymphocytes
Do adaptive immune cells have memory?
Yes. Adaptive immune cells have memory, and memory formation is an integral part of their function.
Which cellular and chemical barriers belong to the adaptive immune system?
Lymphocytes in epithelia (tissue resident and effector cells?); antibodies secreted at epithelial surfaces
Which secreted proteins belong to the adaptive immune system?
Antibodies
Which cells belong to the adaptive immune system?
B and T cells
How fast dooes it take the innate immune system to respond?
It responds almost immediately to PAMPs and DAMPs
How does the innate immune system respond in terms of scale and speed of the response to a second or more exposure of the same kind?
Repeated exposures induce virtually identical innate immune responses
