A. Pseudo-membraneuses: Diphtérie Flashcards

1
Q

Diphtérie: germes

A
  • corynebactérium diphtériae, ou
  • C. ulcérans (BG+)

-> formes productrices de toxines: engageant le risque vital

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2
Q

Diphtérie: transmission

A
  • aérienne,

- lésion cutanée chronique

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3
Q

Atteinte ORL à fausse membrane: incubation

A
  • 7j
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4
Q

Atteinte ORL à fausse membrane: symptômes

A
  • angine peu fébrile
  • dysphagie
  • malaise
  • fausses membranes adhérentes et extensives -> parfois obstructive si atteinte laryngée: group
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5
Q

Si toxine +, possibles atteintes: (organes)

A

Atteinte:

  • myocardique
  • neurologique
  • rénale
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6
Q

Atteinte myocardique:

A
  • TDR
  • TDC
  • > surveillance ECG
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7
Q

Atteinte neurologique:

A
  • paralysies périphériques
  • atteinte des muscles respiratoires

A la PL -> dissociation albuminocytologique

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8
Q

Atteinte rénale:

A
  • IRA avec protéinurie

- hématurie

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9
Q

Moyen pour recherche de toxine:

A
  • prélèvement pour culture

- PCR

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10
Q

T:

A
  • sérothérapie avec épreuve de tolérance
  • amoxicilline 14j IV (macrolires si C-I)
    • vaccination en relais
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11
Q

Isolement:

A

isolement reps jusqu’à 2 cultures - -> contrôle 30j

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12
Q

Sujets contacts:

A

-> dépistage + antibiothérapie systématiques + rappel vaccinal

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