A&P sem1 Flashcards
describe levels of organisation in the cells
- chemical e.g: h20
- cell
- tissue
- organ e.g: lungs
-system e.g: cardiovascular
organism e.g: human
what are the 11 systems
**integumentary **- protection, sensation, thermoregulation
cardio vasucalar
**reproductive **- support developing foetus
digestive
skeletal
muscular
urinary - waste excretion, control blood
lymphatic - immune defence, pathogen
nervous - communication, control
endocrine - communication through hormones, glands
respiratory
describe the 4 types of tissue
connective - store energy, fill internal spaces
**epithelial **- layers of cells
neural - ability to conduct electrical impulses
muscular - ability to contract
Organ definition
DISCRETE COLLECTION OF TWO OR MORE TISSUES COOPERATIVELY PERFORMING A FUNCTION
POSITIONING
towards feet
towards head
nearest trunk of body
furthest trunk of body
towards belly button
away from belly button
towards back
towards front
towards feet = SUPERIOR
towards head = INFERIOR
nearest trunk of body =
PROXIMAL
furthest trunk of body = DISTAL
towards belly button = MEDIAL
away from belly button = LATERAL
towards back POSTERIOR/DORSAL
towards front ANTERIOR/VENTRAL
frontal plane
transverse plane
sagittal plane
frontal - cut front and back in half
transverse - cut legs off
sagittal - between eyes
Cavities
Back of body
front of body
Back = dorsal , brain and spinal chord
Front = ventral,
Thoracic cavity : plural and pericardial cavity)
Abdominopelvic cavity: abdominal, pelvic, peritoneal cavities
homeostasis
+
-
maintenance of constant internal environment
+ = exaggerates difference
- = returns to normal
Anatomy of:
CNS
PNS
CNS = brain+spinal chord, transmit motor commands, sensory data
PNS = tissue outside CNS, deliver sensory info to CNS, motor commands to peripheral tissue
homeostasis:
stimulus journey
stimulus
receptor
control centre
effector
response
what are the 3 types of receptors?
special sensory = senses
visceral sensory = internal organs
somatic sensory = skeletal muscle, joints, skin surface
NERVOUS SYSTEM
what division does:
- sensory info
- motor commands
go to?
sensory = AFFERENT
motor = EFFERENT
NERVOUS SYSTEM
what’s the difference between somatic and autonomic nervous system
What are the 2 divisions autonomic system includes
Somatic, have to think about your next action
Autonomic, body responds automatically via PARASYMPATHETIC (rest and digest) / SYMPATHETIC (fight or flight)
NERVOUS SYSTEM
what are the 4 structures of neurones?
where are they found?
anaxonic = brain. small, not common
bipolar = special sense organs
unipolar = cell body lies to one side, sensory neurones of pns
multi polar = cns, control skeletal muscle, 2 or more dendrites, single axon
Spinal chord
What neurones are myelinated, grey or white matter?
Grey matter = unmyelinated neurones
White matter = myelinated afferent neurones, rapid signal delivery
how many segments are there in the spinal chord?
31
what does each segment of the spinal chord contain?
and what do these do in the segment?
pair of dorsal root ganglia = sensory info to spinal chord through sensory neurones and cell bodies
pair of ventral roots = axons and motor neurones
where do dorsal roots and ventral roots bind?
in a single spinal nerve
SPINAL CHORD
what is a dermatome?
specific section of skin controlled by spinal nerves
describe the process of a reflex arc?
1)STIMULUS, activates receptor
2)SENSORY NEURONE activated through dorsal root
3) info processed by CNS
4)MOTOR NEURONE activated through ventral root
5)RESPONSE, by peripheral effector
What is a Golgi tendon organ?
- muscle contracts, senses tension in tendon
- has inhibitive afferent neuron
- too much tension, GTO releases to protect
BRAIN: CEREBRUM
what are the 4 areas and what are they responsible for?
FRONTAL LOBE - somatic motor association area
TEMPORAL LOBE - auditory association area
OCCIPITAL LOBE - visual association area
PARIETAL LOBE - somatic sensory association area
BRAIN
Physical protection?
hint: 3
- cranium bones
- cranial meninges, 3 layers
- cerebrospinal fluid, surrounds all exposed areas of cos
BRAIN
Biochemical isolation?
blood brain barrier, CNS isolated from general circulation
CRANIAL NERVES
On
On
On
They
Travelled
And
Found
Voldemourt
Guarding
Very
Ancient
Horcruxes
Olfactory (S)
Optic (S)
Occulomotor (M)
Trochlear (M)
Trigeminal (B)
Abducens (M)
Facial (B)
Vestibulocochlear (S)
Glossopharyngeal (B)
Vagus (B0
Accessory (M)
Hypoglossal (M)
CRANIAL NERVES ROLE:
Olfactory (S)
Optic (S)
Occulomotor (M)
Trochlear (M)
Sensor, Receptor - olfactory epithelium in nasal cavity
Sensor, Receptor - retina
Motor, Control eye movement
Motor, control eye movement
CRANIAL NERVES ROLE 2:
Trigeminal (B)
Abducens (M)
Facial (B)
Vestibulocochlear (S)
Sensor, eyes, nose, forehead, structures of the mouth.
Motor, control of the chewing muscles
Motor, control lateral movement of eye.
Sensor of taste
Motor, control of facial expressions, tear gland and salivary glands
Sensor, balance and hearing
CRANIAL NERVES ROLE 3
Glossopharyngeal (B)
Vagus (B)
Accessory (M)
Hypoglossal (M)
Sensor, taste
Motor, control of pharyngeal muscles for swallowing.
roles in abdomen and thorax, key in cv system
Motor, control neck and upper back.
Motor, control muscles in tongue
BRAIN
What are the 3 layers on the cranial meninges?
1.dura matter
2. arachnoid matter
3. pia matter
what is a cell membranes resting potential?
-70mV
What are the 4 types of channels in a cell membrane called?
- Leak channels (always open)
- Gated channels (open depending on circumstances)
- Voltage-gated
- Mechanically-gated (respond to pressure e.g: pressing on skin)
Describe:
Depolarization
Repolarization
Hyperpolarization
Depolar = more Na+ into cell so more +, closer to 0mV
Repolar = Na+ back out of cell, back to resting potential
Hyper = K+ channels open, more + leaves, so even lower than -70mV
Describe the chemical gradient on a cell membrane?
What element moves quickest?
What is attracted where?
Higher conc of K+ inside, and higher Na+ outside
K+ moves out faster than Na+ in
Outside + repels K+
Inside - attracts Na+
K+ still move so net loss of +
What is a graded/local potential?
- small stimuli exposes membrane to chemical
- Na+ channel opens = Depolarisation
- depolarisation causes local potential
- stimuli removed = repolarisation
Not always big enough to cause full action potential
What is continuous propagation?
Mexican wave behaviour
Membrane depolarised to +30mV by AP, Na+ then move away to second segment
Causes new AP there
First segment = refractory period
How is an action potential created?
- depolarisation of membrane to threshold -60mV
- Na+ gates open, Na+ in until +30mV
- Na+ gates close, K+ gates open
- brief hyperpolarisation then resting potential
What is saltatory propagation?
when AP jumps from node to node along myelinated axon
Differences between:
Graded Potential and Action Potential?
1GP: no threshold
1AP: must reach threshold
2GP: amount hyper/depolar depends on stimulus
2AP: all or none
3GP: hyperpolaristing or depolarising
3AP: always depolarising
4GP: no refractory period
4AP: refractory period
5GP: most effect on membrane potential occurs closest to stimulation site
5AP: same strength of propagation across whole membrane
What are the 2 types of neurotransmitters?
Excitatory =
- depolarisation postsynaptic membrane, encourages AP
Inhibitory =
- hyper polarisation of postsynaptic membrane, suppress AP
Describe how acetylcholine is realised from a cholinergic synapse?
- AP depolarises pre synaptic terminal
- Ca2+ enters, Act released by exocytosis in synaptic vesicles
- Ach diffuses, binds to postsynaptic receptors
- Na+ channels open = graded depolarisation
- depolarisation stops as Act broken down
NEUROTRANSMITTERS:
Name 5 important neurotransmitters
Acetylcholine
GABA
Dopamine
Serotonin
Norepinephrine/Noradrenaline
NEUROTRANSMITTERS:
Inhibitory or excitatory?
Released by?
What does it do?
GABA, DOPAMINE, SEROTONIN, NOREPINEPHRINE
GABA = inhib, not known
DOPAMINE = excit/inhib, precise muscle control, dopaminergic synapse in CNS
SEROTONIN = excit/inhib, sleep and wake cycle, serotonergic synapse In CNS
NORADRENALINE = excit, brain, adrenergic synapse
TISSUE
What are the different layers and shapes of epithelial tissue?
Layers: simple, stratified
Shapes: cuboidal, squamous, columnar, transitional
TISSUE
What are the 2 components of neural tissue?
Neurones
Neuroglia = support e.g: phagocytosis, repair damaged tissue, nutrients, maintain structure
TISSUE
Summarise the 3 types of muscle tissues?
SKELETAL = striated, voluntary control
CARDIAC = striated, involuntary, intercalated disks (electrical)
SMOOTH = visceral organs e.g: lungs, liver, heart
EPITHELIAL TISSUE 1:
describe:
1. simple squamous
2. stratified squamous
3.simple cuboidal
4.stratified cuboidal
5.transitional
- diffusion, line blood vessels, flat
- line skin, basement membrane has new stem cells, daughter cells pushed to surface = protection
- secretion, tube/duct
- layers, protection, some cells destroyed in secretion
5.change shape, expand contract with bladder contents
EPITHELIAL TISSUE 2:
1. simple columnar
2. pseudostratified columnar
3. stratified columnar
- absorption, microvilli on surface= big SA, height = protection
- nuclei at different heights, cilia move mucus, respiratory tract
- layers = protection, pharynx
TISSUE
Summarise 3 types of glandular secretion
MEROCRINE = merely vesicles discharged
APOCRINE = part of cytoplasm shared
HOLOCRINE = whole cell bursts
TISSUE
What are 3 main components of connective tissue?
- CELLS = fibroblasts, macrophage,apidocytes
- FIBRES = collagen, elastic, 3d branching
- GROUND SUBSTANCE= blood, cartilage, bone
TISSUE
What are the 3 types of cartilage?
HYALINE = chondrocyte, strong, flexible
ELASTIC = more elastic than collagen
FIBROCARTILAGE = intervertebral disk, strong, protect, little movement
TISSUE
What are the 3 types of dense connective tissue?
DENSE REGULAR = tendon, ligament, fibroblasts/collagen so stretchy
DENSE IRREGULAR = tough sheets around organs, collagen
ELASTIC = less common, parallel arrangement
TISSUE
What are the 2 types of loose connective tissue?
ADIPOSE = apidocytes. padding, energy, fill area, insulate
RECTICULAR = structure, e.g: around kidney, liver
TISSUE
what cells produces/maintains cartilage tissue?
chondrocyte
functions of the skeletal system?
- Support against gravity
- Leverage for muscle action
- Protection of soft internal organs
- Storage: Calcium, phosphorous, fat
- Blood cell production
TISSUE
What are the 4 types of tissue membranes?
- MUCOUS MEMBRANE: mucous attract pathogens, cilia clear mucous, areolar under
- SEROUS MEMBRANE: line body cavity, slippery, lube = transudate
- SKIN: stratified squamous epithelium, dense irregular connective tissue so strong
- SYNOVIAL: line, fluid and nutrition for joint
TISSUE
What are the 3 layers between skin and body?
hint: fascia
1.body
2. subserous fascia: areolar tissue
3. deep fascia: dense connective tissue
4.superficial fascia: areolar + adipose tissue
TISSUE
Describe the 3 different types of muscle TISSUE
SKELETAL: striated cells, attach to bones
CARDIAC: striated, intercalated disk allows electric around heart
SMOOTH: smooth, spindle shape cells, blood vessel wall
What does the skeletal system include?
hint: 5
- bones
- cartilage
- joint
- ligament
- other connective tissue
BONE
What are the 6 different types of bone?
- flat: internal table, dipole, external table
- long: longer than they are wide, levers
- short: transfer forces for subtle movements
- irregular: complex shape
- sutral: between skull bones
- sesamoid
BONE
What are the typical features of a LONG bone?
hint: 3
DIAPHYSIS: long shaft, surround medullary cavity
EPIPHYSES: forces transferred in different directions through TRABECULAR (ends)
ARTICULAR CARTILAGE: smooth cartilage, bone forms to joint
BONE
What are the 3 main components of bone tissue?
- GROUND SUBSTANCE: 2/3 , minerals, hydroxyapatite crystals, calcium salt, ions
- PROTEIN: 1/3, type 1 collagen fibres(most abundent)
- BONE CELLS: 2%
BONE
what are the 4 types of cells classified as ‘bone cells’?
mesenchymal stem cells
osteoblasts
osteocytes
osteoclasts
BONE
what are the roles of:
1.osteoblasts
2.osteocytes
3.osteoclasts
- build new bone (Builders)
- maintain bone, communicates through canaliculi
- acids and enzyme dissolve old bone (Crushers)
BONE
Structure of compact bone
( compare to trabecular bone)
OSTEON: column, strength
CENTRAL CANAL: blood supply through osteons
LAMELLAE: layers of matrix
LACUNAE: dimples, osteocytes sit
BONE
Structure of trabecular bone
(compare to compact bone )
NO OSTEONS
TRABECULAE: rods/bone arches, strength if diff direction
RED BONE MARROW: fill between trabeculae, nutrients
YELLOW BONE MARROW: fat store in medullary cavity
BONE
Compare compact and trabecular bone
- C =more dense than T
- C =osteons T =cross bridge network
- C = outer shaft long bone T = inside short/flat bone,
BONE
Compare periosteum and endosteum
PERIOSTEUM: fibrous and cellular layer, nerves and lymphatic vessels
ENDOSTEUM: just cellular layer
BONE
what is the name of bone formation?
what are the 3 types?
OSSIFICATION
Intramembraneous ossification
Endochondral ossification
Appositional bone growth
BONE
1. How are flat bones formed?
2. What is the process called?
- mesenchymal cells differentiate into osteoblasts
- ossification forms spicules of bones
- trabecular bone formed
- remodelled to compact bone
- mesenchymal cells differentiate into osteoblasts
- Intramembraneous ossification