A&P II chapter 19,20,21 Flashcards
what is the 3 functions of the circulatory system
transportation, protection, regulation
what does the blood transport
1, oxygen from the lungs and co2 to the lungs
- nutrients from the digestive tract
- metabolic wastes to the kidneys
- hormones from the endocrine cells to the target cells
- stem cells from the bone marrow/tissues where they will mature
- heat to the body surface to regulate temp
how does the blood protect the body?
- WBC destroy microbes and cancer cells
- antibodies and proteins neutralize toxins and destroys pathogens
- platelets secrete factors that initiate blood clotting
how does the blood regulate
it absorbs or gives off fluid under different conditions, capillaries stabilize fluid distribution
2. buffering acids and bases to stabilize the Ph of the ECF.
what is the clear matrix of the blood
plasma
red blood cells are also known as
erythrocytes
white blood cells are also known as
leukocytes
what are the two types of leukocytes?
granulocytes and agranulocytes
name 3 types of granulocytes
neutrophils, basophils and eosinophils
name 2 types of agranulocytes
monocytes and lymphocytes
name the two main components of blood
plasma and formed elements
what are the formed elements in the blood?
erythrocytes, leukocytes and platelets
which granulocyte is the 1st to arrive on the scene of an infection and is the most plentiful?
neutrophil
what is the job of the neutrophil
to ingest and destroy bacteria
2-4% of these granulocytes produce histamine to fight inflammation but cannot meet the infection?
basophils they are pro inflammatory and promote allergy
which type of neutrophil goes after parasites like hook worm?
eosinophils
which agranulocytes circulates in the blood looking for infection?
monocytes
which agranulocyte can move out into the tissue and can fight some cancer cells?
monocytes
name the agranulocyte that is associated with T-cells and B-cells
lymphocytes
which formed element of the blood is responsible for clotting?
platelets
what 3 layers are formed when blood is centrifuged?
- erythrocyte layer
- (Buffy coat) WBC and platelet layer
- then the plasma
which layer is made up of 45% of the total volume and is called the hematocrit
erythrocyte layer
where does the erythrocyte layer settle in the collection tube?
the bottom r/t its denseness
what is the cream colored zone in the tube called and what % of the blood volume does it represent?
buffy coat layer and is 1%
which layer is at the top of the blood tube and what % does It represent?
plasma and is accounts for nearly 55%
what is blood plasma comprised of?
water, proteins, nitrogen compounds, nutrients, electrolytes, gases and hormones
what is the most abundant part of the plasma?
protein
what are the three main types of proteins in the plasma?
albumin,
globulins
and fibrinogen
albumin has two physical properties of blood which are?
osmolarity and viscosity
what represents 60% of the plasma protein?
albumin
which part of the plasma protein is responsible for helping form a blood clot?
fibrinogen it represents 4% of the plasma protein
which nutrients are found in the blood plasma?
glucose, lipids, amino acids, vitamins, minerals
which electrolyte makes up 90% of the blood cation?
sodium which is most important for blood osmolarity and has a major influence on blood volume and pressure
what other components are found in the blood plasma?
respiratory gases ( oxygen and carbon dioxide)
the number of solute particles present in a solution is called
osmolarity
what determines the osmolarity of blood?
sodium ions, protein (albumin )and RBC’s
if there is an increased osmolarity of the blood ( more particles in the blood) which way will the water flow?
the water will flow from the tissues to the blood. this will increase the fluid volume of the blood and there for increase the blood pressure and increase the strain on the heart and blood vessels.
if there is a decreased osmolarity of the blood what will happen to the water?
the water will move from the blood to the tissues, resulting in edema, loss of blood volume will decrease the blood pressure.
what will be the affects of low sodium, low albumin and low RBC’s r/t decreased osmolarity in the blood?
anemia, low b/p and edema
what is the measure of thickness of the blood called
viscosity
how is viscosity important to the blood
it regulates the flow of blood though the vessels
what happens if there is an increase in the viscosity of blood?
the blood will flow too slowly like with polycythemia
what happens if there is a decrease in the viscosity of blood
the blood will flow too quickly like with anemia
what are the two types of polycythemia?
primary -found in the bone marrow and secondary- found in people of higher altitudes, increased air pollution and smokers.
what is the production of blood called?
hemopoiesis
what is the name of tissues that produce blood cells
hemopoietic tissue
where is the first hemopoietic tissue formed?
the embryo yolk sac
what organs produce RBC’s before birth?
liver, spleen and thymus
what is the production of lymphocytes called and where does it take place?
lymphopoiesis takes place in the spleen, thymus, tonsils and nodes
name of the process of blood formation from the lymphatic tissues and organs
lymphoid hemopoiesis
where do pluripotent stem cells (PPSC) originate and where are some of them kept?
they originate in the common bone marrow and a small amount is maintained in the marrow.
what are the specialized pluripotent stem cells called and what happens to them?
they are called colony forming units (CFU’s) and they become destined to form a specific type of formed element like a WBC or leukocyte
how many RBC’s does a body produce on a daily basis?
200 billion
how often is the blood plasma replenished?
on a continual basis
where does the plasma derive its components?
it obtains water, electrolytes and nutrients from the digestive tract, gamma globulins comes from the plasma cells and proteins from the liver
name 3 things a RBC does not have the ability to do/have
they do not replicate
they cannot perform mitosis
they do not have a nucleus or DNA
how many days does an erythrocyte live?
120 days
what is the two critical functions of an erythrocyte?
to pick up oxygen from the lungs to the tissues and to pick up carbon dioxide from the tissues and brings it to the lungs
which cell is the most critical to survival since they carry oxygen?
erythrocyte’s
what determines a person’s blood type?
the outer protein layer of the RBC
what is the name of the two cytoskeletal proteins in the inside of the RBC that give the membrane its durability and resiliency?
spectrin and Actin
how many protein chains are present to form hemoglobin? and what are they called?
the alpha chain and the beta chain, there are two of each group to make 4 chains
what is the name of the nonprotein group that each chain is bound to?
a heme group which has iron at its center and binds to oxygen
if every chain has a heme group and there are four chains and four heme groups than how many oxygen molecules can it bind to one hemoglobin molecule?
four
where does the carbon dioxide molecules bind in the hemoglobin molecule?
to the protein chains not the heme group like oxygen
the most common measurements of blood?
hemoglobin, hematocrit and RBC count
what is the hematocrit(PCV or packed cell volume)which measures the whole blood volume composed of the RBC’s values in men and women?
men 42-52% and women 37-48%
what is the concentration of hemoglobin for men and women?
men 13 -18 g/dl and women 12-16 g/dl
what is the measurement of RBC’s in men and women?
men 4.6 - 6.2 million and women 4.2-5.4 million
why are the values higher in men?
- men have higher androgen levels and androgens stimulate RBC production
- women loose blood due to menses
- hct is proportional to body fat- so the more fat the lesser the hct.
what is the production of erythrocytes called?
erythropoiesis
how many days does it take for a RBC to form?
3-5 days
what is the first step in RBC production?
the pluripotent stem cell(PPSC) becomes a colony forming unit (CFU)that has receptors for erythropoietin (EPO).
what is the second step in RBC production?
the EPO stimulates the ECFU to transform itself into a erythroblasts(immature cell) which divides and makes hgb
what is the third step in RBC production?
the nucleus of the erythroblast disintegrates and is discharged from the cell and this results in the reticulocyte forming. once in the blood stream it mature in 2 days.
where is the RBC grave yard?
the spleen
where is erythropoietin EPO created?
in the kidney which stimulates the bone marrow to increase the RBC count.
if the RBC count decreases what happens to the oxygen carrying ability?
it decreases causing hypoxia
how many days does it take to restore the RBC count through the release of EPO?
4 days
what would be a sign that the RBC’s are rapidly degrading (dying)?
a tender or enlarged spleen
which form of polycythemia is induced and temporary?
secondary type. this could be r/t dehydration where the concentration of RBC’s are up because there is not enough water in the blood to reduce the viscosity and factors that cause hypoxia like smoking, pollution and high altitudes.
how can polycythemia lead to heart failure, embolism and stroke?
due to increased viscosity, blood pressure and blood volume
what is the disease that affects the oxygen carrying ability of the blood d/t few RBC’s and abnormal hgb?
anemia
what are the three causes of anemia?
hemorrhage,
hemolytic d/t destruction of the RBC’s and inadequate RBC production.
what are 3 complications r/t anemia?
reduced blood osmolarity causing edema & tachycardia since the blood is thin the heart beats faster and decreased b/p due to the reduced blood volume and viscosity
what disorder is caused by a recessive allele that modifies the structure of the hgb?
sickle cell disease
the interaction between molecules called antigens on the RBC’s and antibodies created what?
blood type
what is produced by proteins in the plasma cells when the body detects an antigen?
antibodies
what binds to antigens and marks them for destruction?
antibodies
what is the unique protein, glycoprotein and glycolipid that are on the surface of all cells that help the body distinguish its own cells from foreign molecules
antigens