A/Ant

Question 1

Noradrenaline receptors?

Answer 1

Binds mostly to alpha, some beta receptors

Question 2

Noradrenaline on HR

Answer 2

Increase due to some beta activity (vasodilation)

Question 3

Noradrenaline on BP

Answer 3

High increase due to vasoconstriction

Question 4

Adrenaline receptors?

Answer 4

Binds to both alpha and beta receptors (slightly more to beta)

Question 5

Adrenaline on HR

Answer 5

High increase due to beta-activity (vasodilation leads to reflex tachycardia)

Question 6

Adrenaline on BP

Answer 6

Same as alpha and beta activity cancel out

Question 7

Isoprenaline receptors?

Answer 7

Very strongly binds to beta-receptors (non-selective)

Question 8

Isoprenaline on HR

Answer 8

High increase due to vasodilation, leading to reflex tachycardia

Question 9

Isoprenaline on BP

Answer 9

High decrease due to widespread vasodilation

Question 10

Prazosin receptor?

Answer 10

Alpha1-blocker

Question 11

Prazosin on HR

Answer 11

Increase with all agonists, as it blocks vasoconstriction, leading to vasodilation, leading to reflex tachycardia

Question 12

Prazosin on BP

Answer 12

Drop due to vasodilation,
although Prazosin + Noradrenaline = no change to BP as vasoconstriction and vasodilation cancel out

Question 13

Atenolol receptor?

Answer 13

Beta-1 blocker (more cardio selective)

Question 14

Atenolol on HR

Answer 14

Drop with Noradrenaline, as Atenolol does not block beta2 receptors, so noradrenaline still active.
Increase with Adrenaline and Isoprenaline due to Atenolol’s activity on beta-2 receptors, causing vasodilation

Question 15

Atenolol on BP

Answer 15

Drop due to decreased force of contraction, block of sympathetic nervous system, and block of renin in the RAAS

Question 16

Propranolol receptor?

Answer 16

Beta-1 and Beta-2 blockers (less cardio selective)

Question 17

Propranolol on HR

Answer 17

Drop with Noradrenaline as it blocks Noradrenaline’s activity.
Increase with Adrenaline and Isoprenaline.

Question 18

Propranolol on BP

Answer 18

Increased with Noradrenaline as alpha1 activity is the only one not blocked (vasoconstriction).
Decreased with Adrenaline and Isoprenaline due to widespread dilation.