A-21. Antiarrhythmic Agents

Question 1

Class I/A

Answer 1

MOA: Na + channel inhibitors, intermediate dissociation and K channel inhibition.

Drugs:

1. Quinidine
2. Disopyramide
3. Procainamide

Question 2

Class I/B

Answer 2

MOA: Na + channel inhibitors, fast dissociation.

Drugs:

1. lidocaine
2. mexiletine
3. phenytoin

Question 3

Class I/C

Answer 3

MOA: Na + channel inhibitors, slow to very slow dissociation.

Drugs:

1. flecainide
2. propafenone

Question 4

Class II

Answer 4

MOA: BB- sympathetic tone decreasers.
1. propranolol
2. esmolol
and many others…

Question 5

Class III

Answer 5

MOA: K + channel inhibitors.

Drugs:

1. sotalol
2. bretylium
3. amiodarone
4. dronedarone
5. ibutilide
6. dofetilide
7. vernakalant

Question 6

Class IV

Answer 6

MOA: Ca ++ channel blockers.

Drugs:

1. dihydropyridines
2. verapamil
3. diltiazem

Question 7

Class V

Answer 7

Drugs:

1. adenosine
2. digoxin
3. atropine
4. magnesium
5. ivabradine