a Flashcards

1
Q

How is respiatory pressure described?

A

Relative to atmospheric pressure.

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2
Q

How does Ppul change with breathing?

A

Fluctuates. Eventually always eventually equalises itself with atmospheric pressure if the airways are open to the atmosphere.

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3
Q

How does Pip change with breathing.

A

Usually less that intrapulmonary pressure and atmospheric pressure except during active (forced) respirations.

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4
Q

What two forces act to pull the lungs away from the thoracic wall.

A

Elasticity of lung tissue and surface tension of alveolar fluid

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5
Q

What counteracts the collapsing forces in the lungs?

A

The elasticity of the inflated chest wall pulls the thorax outwards to enlarge the lungs.

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6
Q

When can lung collapse only occur?

A

When the integrity of the chest wall is compromised during a pneumothroax.

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7
Q

What is Boyle’s gas law?

A

P1V1=P2V2. It shows that the relationship between the pressure and volume of a fixed amount of gas molecules within an enclosed container.

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8
Q

How is air expelled from the lungs during exercise.

A

The expiratory muscles are used.
These are external oblique, internal oblique, rectus and transverse.

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9
Q

How is the relationship between airflow (F) , the pressure driving the airflow (P), and the resistance to the airflow described?

A

F=ΔP/R

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10
Q

What does F=ΔP/R mean?

A

Airflow is inversely proportional to airway resistance.

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11
Q

What causes airway resistance?

A

Bronchoconstriction.

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12
Q

What determines lung compliance?

A

Distensibility of lung tissue due to elastic tissues in lungs.
Surface tension of the alveoli.

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13
Q

What factors diminish lung compliance?

A

Fibrosis (scar tissue)
Blockage of passages with mucous, fluid, bronchospasm
Reduced production of lung surfactant

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14
Q

What is the respiratory membrane?

A

The structures that separate the alveolar air from the pulmonary capillary blood.

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15
Q

What factors impact the rate of O2 and CO2 across the respiratory membrane in the alveoli?

A

Pressure gradients
Surface area.
Thickness of the respiratory membrane

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16
Q

What does Dalton’s law of partial pressures say?

A

Rate of diffusion across the respiratory membrane is dependent on the concentration gradiant or partial pressure gradient.

17
Q

What is the partial pressure of o2 in the alveolar air and in mixed venous blood? Therefore what is the concentration gradient of O2 across the respiratory membrane.

A

104mmHg vs 40mmHg
CG=64mmHg

18
Q

What is the pressure gradient of CO2 across the respiratory membrane?

A

PCO2 is 40mmHg in alveolar air.
PCO2 is 45mmHg in mixed venous blood.
Therefore pressure gradient is 5mmHg

19
Q

What is PO2 and PCO2 in atmospheric air?

A

PO2=160mmHg
PCO2=0.3mmHg

20
Q

What is the PO2 and PCO2 in the alveoli?

A

PO2=104mmHg
PCO2=40mmHg

21
Q

What is PO2 and PCO2 in the venous mixed blood?

A

PO2=40mmHg
PCO2=45mmHg

22
Q

What is the PO2 and PCO2 in blood leaving pulmonary capillaries?

A

PO2=104mmHg
PCO2=40mmHg
Same as alveolar air

23
Q

What is ventilation?

A

The volume of gas that reaches the alveoli each minute.

24
Q

What is perfusion

A

The volume of blood reaching alveolar pulmonary capillaries each minute.

25
Q

What is the primary mechanism for regulating ventilation-perfusion coupling?

A

Vasoconstriction of the small pulmonary blood vessels when the local PO2 decreases. This is called hypoxic pulmonary vasoconstriction.

26
Q

What is the function of hypoxic pulmonary vasoconstriction?

A

Diverting pulmonary blood flow away from poorly ventilated alveoli.