9 Thresholds + Risks

Question 1

Perception of Risk

Answer 1

Less control creates more fear (car vs. plane accidents)
Less knowledge creates more fear (radiation vs. smoking)

Question 2

Risk analysis aims to…

Answer 2

2. Assist rational decision making
3. Beak complex process into manageable components
4. Employ a quantitative approach

Question 3

what are the two main things needed to assess magnitude of risk?

Answer 3

QUALItative data (what effect some toxicant may have)
QUANTitative data (how readily event happens)

Question 4

What is a clearer definition of Risk in toxicology?

Answer 4

Hazard x Exposure
* Risk increases with exposure or potency of toxicant

Question 5

Hazard

Answer 5

intrinsic capability of substance to cause adverse effect

Question 6

Four Steps in Risk Assessment

Answer 6

1. Hazard Identification
2. Dose Response
3. Exposure Assessment
4. Risk Characterization

Question 7

How do we get a point of departure and what is it?

Answer 7

Through in vivo data and dosing regime we get this point
* base recommendations on this point

Question 8

Chemical Risk Assessment

Answer 8

Toxicologists evaluate risk to human health for industrial chemicals ➔ presented to regulators ➔ put controls on volume allowed to be imported or made and restrict access if required