9- Receptors

Question 1

C1 drugs

Answer 1

Illegal

Question 2

C-II drugs

Answer 2

Morphine, methylphenidate

Question 3

C-III drugs

Answer 3

Drugs like Tylenol #3, codeine mixtures

Question 4

C-IV drugs

Answer 4

Benzodiazepines

Question 5

C-V drugs

Answer 5

OTC

Question 6

True receptors elicit a response when?

Answer 6

When bound by an agonist

Question 7

What happens when a drug binds to a nonregulatory molecules

Answer 7

There is no response

Question 8

Covalent >Ionic> Hydrogen> hydrophobic> Van der Waals

Answer 8

Bond strength from strongest to weakest

Question 9

Weak bonds have more selective or less selective binding?

Answer 9

More selective binding

Question 10

Strong bonds will bind to receptor tightly or loosely?

What effect will this have?

Answer 10

Very tightly

Longer lasting effects

Question 11

Why is drug shape important

Answer 11

Proper binding with receptor

Question 12

Look at slide 11-13

Answer 12

Chirality

Question 13

What are the ligand gated ion channels?

Answer 13

Nicotinic ACh

Glutamate

GABA

Question 14

Where are nicotinic ACh receptors found?

Answer 14

Neuromuscular junction
Autonomic ganglia
CNS

Question 15

What opens the nicotinic ACh receptors

Answer 15

Binding of 2 ACh molecules

Question 16

Glutamate receptor agonists include…

Answer 16

AMPA
Kainite
NMDA

Question 17

Glutamate is a major excitatory or inhibitory NT

Answer 17

Excitatory

Question 18

GABA is a major excitatory or inhibitory NT

Answer 18

Inhibitory

Question 19

GABA receptors are used by what kinds of drugs

Answer 19

Anxiety and sleep disorders

Question 20

Voltage gated channels open due to what

Answer 20

Changes in membrane potentials

Question 21

T/F voltage gated ion channels are opened by NT

Answer 21

False

Question 22

Where are voltage gated ion channels found

Answer 22

In excitable tissues

Question 23

Gs does what?

Answer 23

Activates adenylyl cyclase

Increase cAMP

Question 24

Gi does this

Answer 24

Inhibits adenylyl cyclase

Decreased cAMP

Question 25

Gq does what

Answer 25

Actives phospholipase C | Makes IP3 and DAG

Question 26

Gs coupled receptors include.... (2)

Answer 26

``` B adrenergic (B1,2,3) D1 ```

Question 27

Gi receptors include... (3)

Answer 27

M2, D2, A2

Question 28

Gq receptors include... (3)

Answer 28

A1, M3, M1

Question 29

What are growth factor receptors (tyrosine kinases)

Answer 29

Insulin EGF PDGF HGF

Question 30

What are cytokines receptors?

Answer 30

GH, erythropoietin, interferons

Question 31

T/F receptor tyrosine kinases have an intracellular intrinsic kinase activity

Answer 31

True

Question 32

Do cytokine receptors have an intrinsic factor?

Answer 32

No, they are mediated by JAK | JAK activates STAT

Question 33

What is so special about steroid hormones

Answer 33

They are lipophillic, meaning they can pass right through the plasma membrane

Question 34

Nitric Oxide readily crosses the membrane and reacts with what molecule?

Answer 34

Guanylyl cyclase

Question 35

What are some examples of steroid hormones?

Answer 35

Corticosteroids, mineralocorticoids, sex steroids, thyroid hormone, vit D

Question 36

What does NO stimulate

Answer 36

CGMP formation and downstream signaling

Question 37

What are some 2nd messenger systems

Answer 37

CAMP CGMO IP3 DAG