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Pharmacology > 9- Receptors > Flashcards

9- Receptors Flashcards

1
Q

C1 drugs

A

Illegal

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2
Q

C-II drugs

A

Morphine, methylphenidate

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3
Q

C-III drugs

A

Drugs like Tylenol #3, codeine mixtures

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4
Q

C-IV drugs

A

Benzodiazepines

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5
Q

C-V drugs

A

OTC

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6
Q

True receptors elicit a response when?

A

When bound by an agonist

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7
Q

What happens when a drug binds to a nonregulatory molecules

A

There is no response

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8
Q

Covalent >Ionic> Hydrogen> hydrophobic> Van der Waals

A

Bond strength from strongest to weakest

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9
Q

Weak bonds have more selective or less selective binding?

A

More selective binding

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10
Q

Strong bonds will bind to receptor tightly or loosely?

What effect will this have?

A

Very tightly

Longer lasting effects

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11
Q

Why is drug shape important

A

Proper binding with receptor

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12
Q

Look at slide 11-13

A

Chirality

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13
Q

What are the ligand gated ion channels?

A

Nicotinic ACh

Glutamate

GABA

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14
Q

Where are nicotinic ACh receptors found?

A

Neuromuscular junction
Autonomic ganglia
CNS

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15
Q

What opens the nicotinic ACh receptors

A

Binding of 2 ACh molecules

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16
Q

Glutamate receptor agonists include…

A

AMPA
Kainite
NMDA

17
Q

Glutamate is a major excitatory or inhibitory NT

A

Excitatory

18
Q

GABA is a major excitatory or inhibitory NT

A

Inhibitory

19
Q

GABA receptors are used by what kinds of drugs

A

Anxiety and sleep disorders

20
Q

Voltage gated channels open due to what

A

Changes in membrane potentials

21
Q

T/F voltage gated ion channels are opened by NT

A

False

22
Q

Where are voltage gated ion channels found

A

In excitable tissues

23
Q

Gs does what?

A

Activates adenylyl cyclase

Increase cAMP

24
Q

Gi does this

A

Inhibits adenylyl cyclase

Decreased cAMP

25
Q

Gq does what

A

Actives phospholipase C

Makes IP3 and DAG

26
Q

Gs coupled receptors include…. (2)

A 
B adrenergic (B1,2,3)
D1
27
Q

Gi receptors include… (3)

A

M2, D2, A2

28
Q

Gq receptors include… (3)

A

A1, M3, M1

29
Q

What are growth factor receptors (tyrosine kinases)

A

Insulin
EGF
PDGF
HGF

30
Q

What are cytokines receptors?

A

GH, erythropoietin, interferons

31
Q

T/F receptor tyrosine kinases have an intracellular intrinsic kinase activity

A

True

32
Q

Do cytokine receptors have an intrinsic factor?

A

No, they are mediated by JAK

JAK activates STAT

33
Q

What is so special about steroid hormones

A

They are lipophillic, meaning they can pass right through the plasma membrane

34
Q

Nitric Oxide readily crosses the membrane and reacts with what molecule?

A

Guanylyl cyclase

35
Q

What are some examples of steroid hormones?

A

Corticosteroids, mineralocorticoids, sex steroids, thyroid hormone, vit D

36
Q

What does NO stimulate

A

CGMP formation and downstream signaling

37
Q

What are some 2nd messenger systems

A

CAMP
CGMO
IP3
DAG

Pharmacology (4 decks)

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