9. Nonsense mediated decay Flashcards
1
Q
What is the purpose of NMD?
A
mRNA surveillance mechanism that protects cells by reducing production of potentially harmful proteins translated from aberrant mRNA transcripts
2
Q
How does NMD protect the cell?
A
Removes transcripts that may give rise to protein with GoF or dominant negative effect
3
Q
What is non-stop mediated decay?
A
Targets transcripts lacking a stop codon
4
Q
What is no-go mediated decay?
A
Targets transcripts on which ribosomes have stalled
