(9) Derivatives of COOH Flashcards

1
Q

What are the two derivatives of carboxylic acids?

A

Esters and acyl chlorides

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2
Q

What is an ester and how is it formed?

A

(COO-)formed from condensation reaction between carboxylic acid and alcohol

R - C = O
l
O - C - R

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3
Q

What are acyl chlorides and now are they formed?

A

(-COCI )formed when carboxylic acid reacts with PCI5. OH in COOH replaced with CI

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4
Q

Describe observations when COOH reacts w/ PCI.5

A
  • Heat released
  • white solid appears
    -Misty fumes ( HCI )
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5
Q

How do you name an ester

A

-Part from carboxylic acid; no. of carbons-oate
- Part from alcohol; no. of carbons-yl

Alcohol first then carboxylic acid

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6
Q

How to name acyl chlorides

A

written no. of carbons-oyl chloride

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7
Q

smells of esters

A

neutral liquids; pleasant, fruity odour

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8
Q

esters solubility in water

A
  • very small esters are soluble in water as C=O is polar so can form H-bonds with water
  • larger chain esters solubility decreases as C=O looses influence
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9
Q

what type of intermolecular bonds do esters have

A

permanent dipole-dipole attractions and van der Waals

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10
Q

why are the bpt of esters lower than acids

A

cannot form H-bonds

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11
Q

bpt trend in esters as chain increases

A

-inc. no. of electrons
-greater van der Waals
-more emergy required to break forces between molecules
-bpt inc.

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12
Q

two ways esters can be formed

A
  • alcohol and a carboxylic acid
  • alcohol and acyl chloride
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13
Q

describe reaction between alcohol and carboxylic acid to form an ester

A

-H from OH alcohol and OH from COOH forms water
-remainder of alcohol and carboxylic acid form ester

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14
Q

state how an ester is collected during preparation

A

-reaction mixture heated gently in distillation
-larger esters reflux required

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15
Q

why is conc sulfuric acid added to alcohol and carboxylic acid reaction mixture to form ester

A

it acts as a catalyst and dehydrating agent (removes water therefore equilibrium favouors RHS

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16
Q

describe reaction between alcohol and an acyl chloride to form an ester

A

-H form OH alcohol and Cl form COCl forms water
-remainder of alcohol and acyl chloride form ester

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17
Q

why does the reaction of acyl chloride and alcohol produce a higher yield of ester without need for conc acid or heating?

A

-it is a complete reaction (not in equilibrium)

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18
Q

disadvantage of forming ester with alcohol and acyl chloride

A
  • misty acidic fumes of HCl
  • must be under anhydrous conditions
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19
Q

why must you open tap form time to time while shaking reaction mixture with sodium carbonate solution

A

to release pressure

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20
Q

how to tell which layer is aqueous layer in separating funnel when forming an ester

A

add water and whichever layer increases in volume is aqueous

21
Q

why is mixture shaken with sodium carbonate solution when preparing an ester

A

to remove acidic impurities, neutralises conc sulfuric acid catalyst

22
Q

what is the use of anti bumping granules

A

to promote smooth boiling

23
Q

why is anhydrous calcium chloride added when preparing an ester

A

drying agent, to remove water impurities from ester

24
Q

what are lipids

A

naturally occurring esters of carboxylic acid

25
Q

use of lipids

A

source of energy in animal diets and play vital roles in cell membranes and nervous system

26
Q

lipids solubility

A

soluble in organic solvents but insoluble in water (means dont interfere with reactions in cytoplasm of cell)

27
Q

main group of lipids

A

fats and oils

28
Q

how to distinguish between fat and oil physically

A

fats = solids
oils = liquid

29
Q

how are fats and oils formed

A

the reaction between propane-1,2,3-triol with long chain carbojxylic acids

30
Q

common fatty acids

A
  • stearic acid (C.17H.35COOH) — octadecanoic acid
  • oleic acid (C.17H.33COOH) — (9Z)-octadec-9-enoic acid
31
Q

how do fatty acids vary

A

-length of carbon chain
-saturated or unsaturated

32
Q

difference between saturated and unsaturated fatty acids

A

s = each carbon is C-C
u = one or more C=C

33
Q

propane-1,2,3-triol + one/two/three fatty acids →

A

fat/oil + mono-/di-/triester

(most fats are triesters/triglycerides)

34
Q

fatty acid forumla

A

O
ll
C—R
l
OH

35
Q

what are fatty acids called when they contain just one C=C/two or more C=C

A

one C=C → mono unsaturated
Two or more C=C → polyunsaturated

36
Q

Describe the mpt of fats with mainly saturated fatty acids

A
  • more effective van der waals between fat molecules → greater energy required to break forces
  • Higher mpt→ likely to be solid at room temp.
37
Q

Describe mpt of a fat with a large proportion of unsaturation

A
  • Weaker vdW between fat molecules→less energy needed to break forces
  • lower melting point → liquid at room temp.
38
Q

What is transesterification

A

The process of swapping an alkyl group in an ester for a different alkyl group,
Changes intermolecular forces between the molecules

39
Q

What can a transesterification reaction between fats/oils and methanol be use for?

A

To produce biodiesel or margarine

40
Q

What is a biodiesel?

A

A renewable fuel made from veg oils such as rapeseed, palm and soybean oils.
Can be used in normal diesel engines to power cars and buses

41
Q

What can occur after transesterification?

A

-Hydrogenation → Transesterification in this case
Changes carboxylate groups within same fat molecule ( intramolecular exchange) or between fat molecules ( intermolecular exchange

42
Q

Conditions needed for transesterification to occur?

A

At 400k in presence of an alkali (usually NaOH), glycerol and a catalyst

43
Q

How can unsaturated oil be hardened?

A

Hydrogenating it in presence of finely divided nickel at 180°

44
Q

What does hydrogenation do?

A

Results in an increase of vdw between molecules which raises mpt of liquid oil making it a solid fat

45
Q

why would we not want to remove all C=C in unsaturated fats

A

there are possible health benefits

46
Q

describe the effects on health by eating saturated fats

A
  • provides energy and insulation
    -can raise levels of cholesterol in blood which can lead to coronary heart disease or stroke
47
Q

describe the effect on eating polyunsaturated fats

A
  • can have a beneficial effect on heart when eaten in moderation or to replace saturated or trans fats
  • reduces bad cholesterol levels and increases HDL levels which reduces coronary heart disease
48
Q

large esters in fats/oils + conc NaOH solution

A

—> glycerol and sodium salt* of fatty acid

*sodium salts are important ingredients in soap (why alkaline hydrolysis of fats is called saponification)

49
Q

acyl chlorides + water

(describe observations and type of reaction as well)

A

carboxylic acid + hydrogen chloride gas

(fizzing, misty fumes of HCl)
(hydrolysis reaction)