9: calcitonin, erythro, vit d, parathyroid Flashcards
site of synthesis of calcitonin in the thyroid gland
parafollicular/C cells
the primary function of calcitonin is the decrease phosphate & __ ___ and ____ cell synthesis and activity, thereby inhibiting bone resorption
plasma calcium
osteoclast
clinically, calcitonin is used for the tx of ___ & ___
osteoporosis
paget’s
site of synthesis for erythropoietin (2)
kidney
liver (FETUS)
function of erythropoietin is to stim the development of ____
RBC
erythropoietin controls secretion of hormones including (2):
sub P
thyroxine
vit d is synthesized in the ___ for 25-(OH) D3 type and ___ for all types
liver
kidney
chem class that vit d belongs to
seco-steroid
1,25(OH)2D3 is related to the ___ and hydroxcholecalciferol/calcifediol is related to ___
kidney
liver
vid d is TIGHTLY reg by the activity f the ____ in the kidney, major control is ____ hormone
1-a-hydroxylase
parathyroid
vit d primarily functions to increase __ __ & __ ___
linear height
plasma calcium
secondary function of vit d is to stimulate the __ ___
integumentary system
two things that control secretion of vit d
plasma calcium
sunlight
vit d deficiencies can be caused by these two things
sun shunning
strict vegetarian diet
increased CVD risk cognitive impairment severe asthma (chidren) some cancers --these can all occur with a deficiency of:
vit d
normal range of vit d
20-50 ng/ml
considered a vit d deficiency
12 ng/ml
parathoromone (PTH) both stimulates ___ & increases ____ synthesis (liver to kidney) via stimulating syth of 1-hydroxlase enzyme
growth
100% vit d
PTH increases ___ ___ by stim osteoclast cell activity
plasma calcium
most powerful hormone to increase plasma calcium & decrease renal reabsorp of phosphorus
pth
PTH decreases __ __ by decreases renal reabsorp
plasma phosphorus
the big 4 secondary functions of PTH are to increase ___, plasma ___, ___, and ___ response
metabolism
glucose
BP
immune
PTH deficiencies: not getting enough ___ or primary ___ via tumor on parathyroid gland
vit d
hyperthyroidism