9/28 lecture Flashcards
Type of bond responsible for Secondary structure of proteins (alpha-helices, beta-pleated sheets)
Hydrogen bond
A linear sequence of amino acids comprises a protein’s _______
Primary structure
The 3-dimensional structure of a protein comprises its _______
Tertiary structure
What type(s) of bonding form a protein’s Tertiary structure?
Hydrogen
van der Waals
Ionic
nonpolar Covalent (disulfide)
OIL RIG
Oxidation
Is
Losing
Reduction
Is
Gaining
Can a protein be made of both alpha-helices AND beta-pleated sheets?
YES
Why are hydrophobic molecules on the inside of myoglobin, not outside?
Because it is energetically favorable for the hydrophobic molecules to avoid water.
If hydrophobic molecules were on the outside of myoglobin, they would be exposed to water. The water would be forced into a more ordered/less entropic arrangement (a clathrate, in this case), which is energetically unfavorable.
CLICKER
On the surface of a membrane protein which is in contact with the membrane’s fatty acid tails, you are most likely to find _______
amino acids with nonpolar side chains
Where does a protein store all of the information required to maintain its Tertiary structure?
in its Primary structure
its primary amino acid sequence
A Prion is _______
A proteinaceous infectious particle.
Prions cause proteins to misfold, rendering those proteins insoluble. The insoluble proteins aggregate into plaques, which cause CNS tissue to die.
spongiform encephalopathy (holes in the brain) ex: Creutzfeldt-Jakob disease, mad cow disease
A chaperone _______
looks for misfolded proteins and refolds them properly, or destroys them
Hemoglobin is an example of a _______protein
cro
A dimer has _______ subunits
2
Hemoglobin is a tetramer. What are its subunits?
2 alpha subunits, which together comprise a dimer
2 beta subunits, which together comprise another dimer
The subunits of hemoglobin interact with each other via _______ bonding
Hydrogen,
Covalent,
van der Waals, &
Ionic
How is the beta globin protein involved in sickle cell anemia?
A mutation in the amino acid sequence comprising the Primary structure of the beta globin protein…
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