9-13-2016 (2)

Question 1

Propofol

marketed drug name

Answer 1

Diprivan

Generic: Propoven or Lipuro

Question 2

Propofol function

Answer 2

short-acting sedative

Question 3

Propofol uses

Answer 3

General anesthesia, sedation for mechanical ventilation pt.’s, procedural sedation.

Question 4

propofol durations of action

Answer 4

5-10 minutes

Question 5

onset action of propofol

Answer 5

15-30 seconds

Question 6

biological half-life of propofol

Answer 6

30-60 seconds

Question 7

Propofol is metabolized in the _______.

Answer 7

liver

Question 8

side effects of propofol

Answer 8

1) pain on injection
2) blood pressure drops
3) apnea (respiratory depressant)
4) mild myoclonia

Question 9

propofol is prepared by __________

Answer 9

emulsifier of soya oil and propofol

Question 10

chemically propofol is:

Answer 10

2,6-diisopropylphenol

non-polar
hydrophobic
insoluble
pH: 6-8.5

Question 11

propofol is administered __________

Answer 11

intravenously

NOTE: pain on injection is a side effect-lidocaine injection can remedy the pain prior to injection.

Question 12

rare symptom of propofol

Answer 12

propofol infusion syndrome

Question 13

Propofol infusion syndrome

Answer 13

high doses and chronic usage

1) High blood potassium
2) High triglycerides
3) Liver enlargement
4) Rhabdomyolytis

Question 14

Rhabdomyolytis

Answer 14

rhab: striated
myo: muscle
lytis: breakdown

indicators: tea-colored urine, high creatine kinase levels

Question 15

Horst Schulze

Answer 15

“If a mistake happens once it may be the fault of the employee. If it happens twice, it is most likely the fault of the system”

Question 16

“Perspective can only be achieved if you put yourself in a position to see the problem from a different point of origin.”

Answer 16

Peter Kozodoy, Forbes