8a - FU Txt

Question 1

What is 5 Fluorouracil txt?

Answer 1

Topical chemotherapy agent used in txt of AK’s, Bowen’s, and some superficial BCC/SCC

Question 2

MOA for 5 FU?

Answer 2

Thymidylate synthase inhibitor

Blocks synthesis of a nucleoside required for DNA replication

Rapidly dividing cancerous cells undergo cell death

Question 3

SE’s of 5 FU

Answer 3

Pain
Itching
Burning
Stinging
Crusting
Weeping
Dermatitis
Photosensitivity

Question 4

Procedure of 5 FU txt

Answer 4

Apply a thin layer to affected area QD-BID

Apply 2-4 weeks depending on severity and location

Irritation and redness may last an additional 2-4 weeks after stopping

Apply OTC HC 1% or Rx Desonide cream, especially in affected areas

Use Aquaphor / petrolatum in raw, cracked areas

Consider Rx of oral analgesics

Question 5

Tips for 5 FU txt

Answer 5

Do it in the fall or winter

Have empathy

Don’t forget about comfort measures

It’s NOT an allergic reaction - 5 FU only attacks ABNORMAL cells

Question 6

How many apples grow on a tree?

Answer 6

All of them