8. Vulvar itch, vaginal discharge, and sexually transmitted disease Flashcards
Describe history: Vulvar itch, vaginal discharge, and STDs (14)
- Vulvar Sx (burning or pruritus)
- Vaginal discharge (consistency, color, odor)
- Progression of Sx
- Previous investigations, including cultures, swabs, etc.
- Rx attempted, including antibiotics, antifungals, etc.
- Hygienic practices
- Dysuria (internal vs. external)
- Abdo pain
- Presence of IUD
- Prev. infections
- Menstrual Hx
- Sexual activity, including number of partners, new partners, barrier protection use
- Pregnancy Hx
- PM H x, including H x of diabetes
Describe physical exam: Vulvar itch, vaginal discharge, and STDs (6)
- Inspect external genitalia
- Edema, excoriations, ulceration, condylomas, discharge on the perineum or introitus
- Assessment of inguinal and/or femoral lymph nodes: lymphadenopathy
- Speculum exam:
- Vaginal discharge and lesions, evidence of characteristic lesions (e.g., strawberry cervix of trichomoniasis), presence of cervical discharge
- Assess the presence of cervical and upper genital tract inflammation: Cervical motion tenderness, adnexal tenderness
- Assess the presence of systemic Sx: Fevers, abdo tenderness
- Perform perianal inspection, pharyngeal inspection
Describe investigations: Vulvar itch, vaginal discharge, and STDs (7)
- Vaginal swabs
- Vaginal discharge sample wet mount
- Culture of the endocervix for gonorrhea or chlamydia infection
- Pap test (biopsy if any suspicious areas)
- UrineR&M, C&S
- Vaginal pH (using phenaphthazine paper)—may be altered by lubricating gel, semen, douches, or intravaginal medication
- CBC, specific blood tests (VDRL, treponemal tests, HSV PCR, HAV, HBV, HIV)
Describe: Normal vaginal Discharge (3)
- Physiologic vaginal discharge (1–4 mL of fluid daily)
- pH of normal flora is acidic (4.0–4.5)
- Discharge may ↑at times (pregnancy, use of E contraceptives, mid-cycle).
- ↑mid- cycle due to ↑ cervical mucus → can be malodorous and can be accompanied by irritative Sx
Describe: Vulvovaginitis (2)
- Inflammation of the vulva and vagina due to both infectious and noninfectious causes
- Sx of vaginitis are nonspecific → physical exam and lab findings are required to make a definitive Dx
Name types of infectious vaginitis (4)
- Bacterial vaginosis (40% –50% of cases—most common cause of vaginitis in women of reproductive age)
- Vaginal candidiasis (20%–25% of cases)
- Trichomoniasis (15% –20% of cases)
- Other (less common):
- Atrophic vaginitis with 2° bacterial infection
- Foreign body with 2° infection
- Streptococcal vaginitis (group A)
- Ulcerative vaginitis TSS
- Idiopathic vulvovaginal ulceration related to HIV
Name types of noninfectious vaginitis (5)
- Atrophic vaginitis
- Chemical or other irritant
- Allergic, hypersensitivity, and contact dermatitis
- Neoplastic
- Other:
- Traumatic vaginitis
- Postpuerperal atrophic vaginitis
- Desquamativein ammatoryvaginitis
- Erosive lichen planus
- Lichen sclerosis
- Lichen simplex chronicus
- Collagen vascular disease, Crohn disease
- Behçet syndrome
Name causative agents: Bacterial vaginosis (4)
- G. vaginalis
- Bacteroides
- Peptostreptococcus
- M. hominis
Why is it important to treat Bacterial vaginosis in pregnancy? (1)
↑ Risk of preterm birth
Name signs and sx: Bacterial vaginosis (2)
- Predominant complaint of vaginal odor
- ↑ Risk with uterine manipulation
Name Diagnostic Criteria: Bacterial vaginosis (4)
Amsel criteria (3 of 4):
- Thin homogeneous vaginal discharge
- Clue cells on N/S wet mount or Gram stain
- Positive Whiff test on KOH wet mount (presence of characteristically “ shy” [amine] odor)
- Vaginal pH > 4.5
Name RX options: Bacterial vaginosis (3)
- Metronidazole 500 mg PO b.i.d. × 7d
- Metronidazole 5 g pv daily × 5d
- Clindamycin 5g pv × 7d
Name causative agents: Vaginal candidiasis (3)
- C. albicans
- C. glabrata (less common)
- Associated with antibiotics use, DM, immunosuppression
Name signs and sx: Vaginal candidiasis (3)
- Vulvar/vaginal pruritus
- Vulvar erythema, edema, fissures excoriations, external dysuria
- Thick occulent white discharge
Name Diagnostic Criteria: Vaginal candidiasis (3)
- Normal vaginal pH (4–4.5)
- Hyphae and buds on saline wet mount (yeast)
- Positive yeast culture from the vagina (many asymptomatic women have vaginal yeast colonization)
Name RX Options: Vaginal candidiasis (2)
- Fluconazole 150 mg PO once
- Clotrimazole 500 mg tablet p.v. ×1 or 5 g pv × 3d
Name causative agents: Vaginal trichomoniasis (2)
- T. vaginalis
- Facilitates HIV transmission, associated with PROM
Name signs and sx: Vaginal trichomoniasis (3)
- Dyspareunia
- Vaginal pruritus, vulvovaginal erythema “Strawberry” cervixon exam
- Timing: ↑ common during/ immediately after menses
Name diagnostic criteria: Vaginal trichomoniasis (4)
- Trichomonas (motile agellum) seen on N/S wet mount
- High number of Polymorphonuclear leukocytes (PMNs) on saline microscopy
- Positive culture for T. vaginalis
- Vaginal pH 5–6.0
Name rx options: Vaginal trichomoniasis (3)
- Metronidazole 2 g PO × 1
- Metronidazole 500 mg PO b.i.d. × 7 d
- *Must treat sexual partners simultaneously to prevent reinfection
Who to Test for Gonorrhea and Chlamydia (5)
- Sexually active and < 25 yr
- In all patients who have a fever and lower abdo pain
- A symptomatic sexual partner
- A new sexual partner or more than one sexual partner
- Other STI diagnosed
Name causative agent: Gonorrhea (1)
N. Gonorrhea (diplococci)
Name signs and sx: Gonorrhea (12)
- Cervicitis, PID
- Mucopurulent discharge vagina
- Rectal pain and discharge
- Dysuria, dyspareunia
- Perihepatitis (Fitz-Hugh-Curtis)
- Lower abdo pain
- Abnormal vaginal bleeding
- Chorioamnionitis/endometritis
- Bartholinities
- Conjunctivitis
- Pharyngeal infection
- Disseminated infection (arthritis, dermatitis, endocarditis, meningitis)
Name dx criteria: Gonorrhea (4)
- Nucleic acid testing from endocervical specimens (sensitivity 96% )
- Gram stain of cervical swab sample
- Culture from endocervix, pharynx, rectum, conjunctiva
- Usual incubation period is 2–7 d
Name rx options: Gonorrhea (6)
- Recommended: Cefixime 800 mg PO × 1
- or: Ceftriaxone 250 mg IM × 1 plus Azithromycin 1 g PO × 1
- or Doxycycline 100 mg PO b.i.d. × 7d
-
Alternative
- Azithromycin 2 g PO × 1
- or Spectinomycin 2 g IM × 1
- plus Co-treatment for chlamydia
- Mandatory reporting
- Rx/F/U of partners with contact within 60 d of Sx onset
Name causal agent: Chlamydia (2)
- C. trachomatis
- Serotypes D, E, F, G, H, I, J, K (obligate intracellular bacteria)
Name signs and sx: Chlamydia (8)
- Majority of cases → asymptomatic
- Vaginal discharge
- Dysuria, dyspareunia
- Lower abdo pain
- Conjunctivitis
- Proctitis
- Reactive arthritis
- Incubation period can be up to 6 wk
Name dx criteria: Chlamydia (2)
- Nucleic acid testing assay from endocervical, urethral, or urinary specimen
- Throat and/or rectal culture of C. trachomatisc
Name rx options: Chlamydia (5)
- Recommended: Doxycycline 100 mg PO b.i.d. × 7 d
- or Azithromycin 1 g PO × 1b
-
Alternative :
- Erythromycin 500 mg PO q.i.d. × 7 d
- or Erythromycin 250 mg PO q.i.d. × 14 d
- Mandatory reporting
- Rx/F/U of partners with contact within 60 d of Sx onset
Name repeat screening of Gonorrhea indications (8)
- All cases 6 mo post-Rx
- Test of cure with culture 3 to 7 d after initiation of treatment when:
- Gonococcal pharyngeal infection
- Patient treated with non recommended regimen, including known antimicrobial resistance
- Suspected treatment failure
- Uncertain compliance
- Reexposure to untreated partner
- PID or disseminated infection
- Pregnancy
Name STI RFs (11)
- Previous STI
- Sexually active < 25 yr of age
- Sexual contact with person(s) with a known STI
- A new sexual partner or > 2 sexual partners in the past year/serially monogamous patients
- IV drug use
- No contraception or sole use of a nonbarrier method
- Sex workers and their clients
- Street involvement, homelessness
- Victims of sexual assault/abuse
- Anonymous sexual partnering
- “Survival sex” (i.e., exchanging sex for money, drugs, etc.)
Name C. trachomatis Repeat testing indications (7)
- All cases 6 mo post-Rx
- Test of cure in 3 to 4 wk recommended when:
- Uncertain compliance
- Patient treated with nonrecommended regiment
- Pregnancy
- Test of cure at 3 to 4 wk is not recommended when:
- Standard treatment regimen has been completed
- Signs and Sx have resolved
- No reexposure to an untreated partner
Must consider ____ in any child diagnosed with gonorrhea and/or chlamydia after the immediate neonatal period.
Must consider sexual abuse in any child diagnosed with gonorrhea and/or chlamydia after the immediate neonatal period.
Suspected or known sexual abuse of children must be reported to child protection agencies.
What is the great imitator as it is associated with a variety of signs and Sx (1)
Syphilis
Describe signs and sx: Primary Syphilis (5)
- chancre (genital ulcer), regional
- LAD
- Ulcer is classically painless
- Resolves in 2–8 wk
- Incubation period: 3-90d
Name dx criteria: Primary Syphilis (1)
Dark field microscopy of serous fluid from genital lesions for observation of spirochetes