8. Specialised Circulations Flashcards
What does circulation to an organ depend on?
Perfusion pressure
Vascular resistance
What are the intrinsic factors of vascular resistance?
autoregulation- myogenic, metabolic and endothelial factors
mechanical compression
What are the extrinsic factors?
nervous
Hormonal
What is autoregulation?
The ability of organ to maintain blood flow despite changes in perfusion pressure
When does autoregulation occur?
In the absence of extrinsic factors
What are the features of coronary blood flow?
High basal flow High basal O2 consumption High myocardial O2 extraction High density of myocardial capillaries O2 transport increase by myoglobin myocytes
Control of coronary blood flow
ccc
What is neurohormonal control?
Action of sympathetic nerves and hormones
What affects skeletal muscle circulation?
Sympathetic noradrenergic vasoconstrictior nerves
adrenaline
Sympathetic cholinergic vasodilators nerves
Compression
still more to this
More to this