8 - NMJ Flashcards

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1
Q

what occurs when an action potential reaches a pre-synaptic membrane?

A
  • depol
  • ca voltage gated open
  • ca enters due to more outside
  • cause vesicle fusement
  • ach released
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2
Q

what causes vesicle to fuse with pre synaptic membranes?

A
  • ca entry
  • synaptotagmins sense ca
  • bind with ca and cause confom change
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3
Q

what does ACH bind to?

A

nicotinic receptors [ionotropic ion channel]

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4
Q

in NMJ, describe the structure of the post synaptic membrane?

A
  • called motor end plate
  • junctional folds [sfa]
  • many nACH channles
  • many Na channels
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5
Q

how does Ach binding cause End Plate Potential EPP?

A
  • ach binds to nAch
  • Na and K channels open
  • Na influx higher than K efflux
  • resting Em of muscles = -70mv
  • epp = -20mv [if bigger than threshold = AP]
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6
Q

fate of ACH?

A

acetylcholinesterase

choline + acetate

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7
Q

what is myesethnia gravis?

A
  • less nACHr @ synpase
  • muscle weakness
  • treatment = ACHEsterase inhibitors
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