#8: Anaphylaxis

Question 1

Most critical concerning locations in angioedema: (3)

Answer 1

Tongue
Lips
Face

Question 2

Hereditary angioedema MC affects these 2 locations:

Answer 2

Respiratory

GI tract

Question 3

Hereditary angioedema MC cause and SXS duration:

Answer 3

Minor Trauma

Lasts hours to days (1-2 d)

Question 4

Hereditary angioedema is an autosomal dominant dz characterized by these 2 lab abnormalities:

Answer 4

1- Low/dysfx. Levels of C1 esterase

2- low levels of C4 between acute attacks

Question 5

Prophylaxis agents for acute attacks of angioedema: (2)

Answer 5

1- stanazolol (Winstrol)- 2 mg/day

2- danazolol (Danol)- 200 mg/day

Question 6

Hereditary angioedema acute attacks are shortened with these 2 agents:

Answer 6

Fresh Frozen Plasma

Berinert (C1 esterase inhibitor)

Question 7

SXS consistent with food allergies: (3)

Answer 7

• swelling and itching of the lips, mouth and pharynx
• n/v/d
• abdominal pain/cramps
• -> also lead to anaphylaxis, urticaria, or angioedema

Question 8

Food allergy sensitivity TX: (3)

Answer 8

• MC: H1B

- - also, H2B and Steroids

Question 9

Insect hypersensitivity rxn MC initial SXS: (4)

Answer 9

sxs of local, toxin-mediated rxn:

• pain
• pruritis
• swelling
• redness
• **DO NOT CONFUSE WITH CELLULITIS

Question 10

Allergy Drug rxn risk is associated with this:

Answer 10

ability of the molecule to remain PRO bound (increased, then increased risk for rxn)

Question 11

If pt has a sulfa allergy, they are likely allergic to all sulfa-based products: (8) ABCDG

Answer 11

• Abx (topical): silver sulfadiazine (silvadene) and mafenide acetate
• Bactrim
• Celecoxib
• Diuretics [TZD, loops- furosemide (lasix) and bumetanide (bumex)]
• Glucose regulation: diazoxide and glipizide

Question 12

SXS consistent with a sulfa allergy: (4)

Answer 12

resembles serum sickness:

• arthralgia
• myalgia
• pruritis
• urticaria

Question 13

MC med causes of anaphylaxis: (6)

Answer 13

• β-Lactam antibiotics (PCN MC overall)
• (Bactrim) TMP-SMX
• Vancomycin
• Vaccines
• NSAIDs
• Salicylates

Question 14

MC food causes of anaphylaxis: (7)

Answer 14

Shellfish
Eggs
Nuts (peanuts and tree nuts)
Dairy
Soybeans
Or Wheat
Seeds

Question 15

MC environmental causes of anaphylaxis: (5)

Answer 15

• Radiographic contrast
• Insect particles/hymenoptera stings (2nd MC overall)
• Molds
• Latex