8-18 Synaptic Transmission Flashcards
Metyrosine
Mechanism of Action
Competitive inhibition of tyrosine hydroxylase
Reserpine
Mechanism of Action
Inhibits VMAT uptake of monoamines
Bretylium
Mechanism of Action
Inhibits action potential generation and associated calcium dependent synaptic vesicle fusion.
Cocaine
Mechanism of Action
Blocks monoamine reuptake
Amphetamine or Ephidrine
Mechanism of Action
Reverses monoamine reuptake transporters
Naloxone/Naltrexone
Mechanism of Action
Non-peptide blockers of opioid receptors in the CNS
SSRIs
Mechanism of Action
Selective inhibition of serotonin reuptake transporters
ACE inhibitors (e.g. Lisinopril)
Mechanism of Action
Inhibits peptide cleavage of angiotensin I to angiotensin II
Phenylephrine
Mechanism of Action
Direct agonist of adrenergic receptor
MAO inhibitors
Mechanism of Action
Blockade of cytoplasmic metabolism of monoamines
L-DOPA
Mechanism of Action
Precursor of dopamine. Stimulates dopamine production.
Carbidopa
Mechanism of Action
Blocks L-DOPA conversion to dopamine in peripheral neurons (does not cross BBB).
Tyramine
Mechanism of Action
Competes with NE for transport into synaptic vesicle.
