7.1 Derm 1 Flashcards
Layers of the skin
Epidermis
Dermal epidermal junction (basement membrane)
Dermis
Subcutaneous fat
What is the epidermis composed of
Keratinocytes
(Keratinising stratified squamous)
Divisions of cells in epidermis
Stratum spinosum
Stratum granulosum (granular layer)
Stratum lucidum (only in oalms and soles)
Stratum corneum most superficial (no nuclei or organelles)
How long does it takes for progression of epidermal cells to surface
30 days
Accelerated in skin disease like psoriasis (scaling)
What assists in the structure of epidermis
Strong connections of:
Gap junctions
Adherens junctions
Desmosomes
Tight junctions
Gap junctions
Cell synchronisation differentiation growth and metabolic coordination
Tight junctions
Barrier integrity and polarity
Desmosomes
Major adhesion complexes in epidermis
Bridge adjacent keratinocytes
Allow cells to withstand trauma
Cells in the epidermis
Melanocytes
Langerhans
Merkel
Melanocytes
Dendritic
Distribute melanin pigment in melanosomes to keratinocytes
Equal number in all skin types
Langerhans cells
Dendritic
Antigen presenting
Merkel cells
Mechanosensory receptors
Structure of the dermis (layers)
Support in ecm
Reticular dermis
Papillary dermis (superficial)
What components does the dermis have
Proteins (collagen and elastic fibres)
Glycoprotein
Ground substance
Cells
What are the main cells of the dermis
Fibroblast
Which proteins are seen in the dermis
Collagen types 1 and 3
Elastic fibres fibrillin, elastin
Which glycoprotein are seen in dermis
Fibronectin
Fibulin
Integrins
Function of glycoproteins in the dermis
Facilitate cell adhesion and motility
Cells in dermis
Fibroblasts
Neutrophils
Kymphocytes
Dendritic cells
Mast cells
Which collagen main,y comprise the dermis
1 and 3
Which layer of epidermis is only found in palms and soles
Stratum lucidum
Which layer of the dermis is most superficial
Papillary dermis
Which layer of the dermis is most deep
Reticular dermis
What is the reticular dermis composed of
Dense connective tissue
What is the papillary dermis composed of
Loose connective tissue
Blood supply of the skin
Doesn’t cross to the epidermis (avascular)
Deep and superficial vascular plexus
Innnervation of the skin
Sensory
Autonomic
Cholinergic
Adrenergic
Brain well connected to skin so stress causes disorders of the skin
Meissners corpuscle
Innervation of the skin
Thick hairless skin (lips, finger pads)
For light touch and slow vibration
Ruffini corpuscle
Around Finger nails
Monitors slippage of objects
Sensitive to skin stretch
Pacinian corpuscle
Dermal papillae of hands and feet
Deep touch (detects surface texture)
Merkel cell
Unencapsulated
Light touch
Nerve endings
Meissner
Ruffini
Pacinian
Merkel
Corpuscles (Merkel cell)