7. Oral Sedation Flashcards

1
Q

5-10% Americans have dental phobia and avoid care completely
80% have ____
Even pts that can come in and accomplish procedure with LA (local anesthesia)
If given alternative, would accept that and consider oral sedation as adjunct to their dental procedure

A

dental anxiety

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2
Q

____ is for little scaredy cats while
Oral sedation is for those that are more anxious
7-15% Americans very nervous or terrified of having dental Tx
May not be right group for oral sedation, they may need deep or GA
Preferably GA, since if have to be that deep to have procedure accomplished, creates potential airway problem

GA is for big scaredy cats
Can’t even do it with oral or deep sedation ambulatory anesthesia, may become more combative with some sedation on board.
In those patients, ____ is the only solution

A

NO

GA

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3
Q

Why are people so afraid of dentist? -Bad past ____
-Learned ____ from parent Kids pick up cues from parents
If parents are nervous, they may have conversations with them before a procedure making it difficult to negate what they’ve been told by parents
-Fear of pain: can be alleviated with ____

If you’re working on a pt and they’re not completely numb, are they overly sensitive? Can test gum to see if they really feel it or if they’re just nervous
Might jump even before you touch them if they’re just afraid
Not actually feeling it
-Fear of ____
Drills, needles
If pts know that NO or sedation can get them through a procedure, they can be more reasonable Really first 5-10 minute interaction is important in managing fear of dental procedures
-Embarrassment about poor ____

A
experiences
behavior
LA
dental instruments
OH
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4
Q

ADA guidelines

❖ “ a minimally depressed level of consciousness that retains the patient’s ability to independently and continuously maintain an ____ and respond appropriately to physical stimulation or verbal command . . .”

A

airway

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5
Q

Oral sedatives will most likely be between ____ categories
Normal response to verbal stimulation, airway, ventilation, CV function unaffected in minimal

In ____, there is a purposeful response to verbal or tactile stimulation though they look sedated, no airway intervention required, adequate ventilation, usually maintained CV function

____ may require intervention in airway, they may have questionable ventilation. GA may impair CV function

A

minimal and moderate
moderate
deep

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6
Q

We want to keep them relaxed, anxiolysis, but with consciousness maintained Pts may doze in and out of sleep

Don’t say they’ll be asleep because that’s more like GA in OR with a breathing tube Tell pts it is to relax, to control ____, but not for pain

____ is for pain and will be used in all forms of sedation

But they’ll doze in and out, close eyes, get comfortable
But can easily arouse them, call out name, touch, and they will respond
Not trying to depress consciousness, just ____ them and make our lives easier

A

anxiety
LA
relax

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7
Q
Oral Sedation: Benefits
❖ \_\_\_\_ to administer
❖ Provides anxiety relief
❖ \_\_\_\_ to use
❖ Lower cost
❖ No need for \_\_\_\_ training in parenteral sedation or general anesthesia
A

easy
safe
advanced

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8
Q

Level of sedation

❖ Minimal sedation is equivalent to ____, that is, a drug-induced relief of apprehension with minimal effect on sensorium

A

anxiolysis

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9
Q

Oral Sedation: Limitations

❖ Reliance on patient ____
Have to trust pt will take medication and follow instructions, not take anything else
❖ ____ onset of drug action
Can’t have them go fill rx on the spot and come back and take it, the effect would take an hour
❖ ____ absorption from
the GI tractIf there are other GI issues there can be problems. Ex, 26 yo F with gastroparesis is also taking pain meds and isn’t getting sedated.
There’s also normal variation bw pts (30min vs 2hrs to take effect)
❖ Inability to ____ the dose
❖ Difficult to administer ____

A
compliance
delayed
erratic and incomplete
titrate
reversal agent
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10
Q

Most Commonly Used

❖ ____
❖ Hydroxyzine (Vistaril)
❖ ____

A

benzodiazepines

choral hydrate

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11
Q
Benzodiazepines
 ❖ \_\_\_\_ (Valium)
❖ Midazolam (Versed)
❖ \_\_\_\_ (Ativan)
❖ Alprazolam (Xanax)
❖ \_\_\_\_ (Restoril) 
❖ Triazolam (Halcion)
A

diazepam
lorazepam
temazepam

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12
Q
Oral Sedation:
Benzodiazepines
❖ Diazepam (Valium)
❖ Available in \_\_\_\_
suspension
❖ Minimal \_\_\_\_ and
respiratory effects
❖ Used \_\_\_\_ or in combo
❖ Long elimination \_\_\_\_
A

tablets
cardiovascular
solo
half-life

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13
Q

Diazepam: Advantages

❖ Wider margin of ____
❖ Can administer in doses sufficient for ____

A

safety

anxiolysis

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14
Q

Diazepam: Disadvantages ❖ Production of active ____

A

metabolites

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15
Q
Diazepam: Pharmacokinetics
❖ Reaches peak concentrations rapidly
❖Adults: \_\_\_\_ min 
❖Children: \_\_\_\_ min
❖ Half-life of \_\_\_\_ days
A

60 to 90
15 to 30
1.5

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16
Q

Diazepam: Side Effects

❖ ____ sedation

A

prolonged

17
Q

Diazepam: Recommended Dose

❖ Adults: ____ mg ____ hour before procedure

A

5-20

1

18
Q

Oral Sedation:
Benzodiazepines

 ❖ Midazolam (Versed)
❖ More \_\_\_\_
❖ \_\_\_\_ duration of action
❖ \_\_\_\_ elimination half-life (~ 1 hour)
❖ More reliable \_\_\_\_ effect
A

potent
shorter
shorter
amnestic

19
Q

Midazolam: Pharmacokinetics
❖ Peak plasma levels in ____
❖ ____ half-life
❖ No ____ metabolites

A

30 to 60 min
shorter
active

20
Q

Midazolam:
Recommended Dose

❖ 0.5 mg/kg in children
❖ Variation based on ____, anxiety level, and the
degree of ____ required

A

age

sedation

21
Q

Midazolam: Clinical Use
❖ Administered as ____ dose ❖ Close supervision
❖ ____ staff
❖ Availability of equipment

A

single

knowledgeable

22
Q

Antihistamines
❖ ____ (Vistaril or Atarax)
❖ ____ (Phenergan)

A

hydroxyzine

promethazine

23
Q

Hydroxyzine (Vistaril)

❖ ____ (H1 antagonist)
❖ Less efficacious than ____
❖ Not a very good ____
❖ Frequently used in ____ with other drugs

A

antihistamine
benzodiazepines
anxiolytic
combination

24
Q

Hydroxyzine:
Recommended Dose
❖ Adults: ____ mg
❖ Children: ____ mg/kg

A

50 to 100

0.6

25
Q

Pediatric sedation:
Antihistamines
-Major advantage is ____ effects
-But lots of anticholinergic side effects

Benzos

  • Better ____, sedation
  • Fewer side effects
  • ____

Meperidine out of favor
Ketamine works well, used in peds
-Immobilizes patient and can do ____ lacerations in emergency department setting
-Not something we’d use alone without ____ or something else

Dexmedatomidine
-She doesn’t use this, maybe some pediatric dentists use it

Chloral hydrate

  • She can’t believe this is still being used
  • Because of potential ____ associated with it and there are superior things
A

antiemetic
anxiolysis
anticonvulsant

tongue
benzo

toxicity

26
Q

Pediatric Sedation:

Indications
❖ Extreme ____ or fear
❖ Children under ____ years of age
❖ Developmentally ____ children

A

anxiety
2
disabled

27
Q

Pediatric Sedation:
Goals
❖ (1) Facilitate the provision of ____ care
❖ (2) Minimize the extremes of disruptive ____
❖ (3) Promote a positive psychologic response to ____
❖ (4) Promote patient ____ and safety
❖ (5) Return the patient to a ____ state in which safe discharge, as determined by recognized criteria, is possible

A
quality
behavior
treatment
welfare
phsyiologic
28
Q

Drug effect is determined by:

❖ Drug \_\_\_\_
❖ Drug dose
❖ \_\_\_\_ of administration
❖ Child’s behavior
❖ \_\_\_\_ stage of the child
A

type
route
developmental

29
Q

Sedation Methods:
Oral Sedation

❖ ____
❖ Benzodiazepines
❖ ____
❖ Opioids

A

chloral hydrate

antihistamines

30
Q

Oral Sedation:

Chloral Hydrate
 ❖ Used extensively in \_\_\_\_ dentistry
❖ Mixed with flavoring agent or in capsules
❖ \_\_\_\_ formulations
❖ Used alone and in combination
❖ \_\_\_\_ potential
A

pediatric
oral and rectal
carcinogenic

31
Q

Chloral Hydrate: Pharmacokinetics

❖ Sedative-hypnotic properties attributed to active
metabolite, ____
❖ ____ onset of action
❖ ____ plasma half-life (____ hrs)

A

trichloroethanol (TCR)
short
prolonged
8

32
Q

Chloral Hydrate: Physiologic Effects

❖ Can cause ____
❖ Trichloroethanol (TCE) produces ____ depressant effects
❖ Little effect on ____ systems
❖ Minimal ____ effect

A

nausea and vomiting
CNS
respiratory and cardiovascular
cardiovascular and respiratory

33
Q
Oral Sedation:
Antihistamines
 ❖ Provides light \_\_\_\_ sedation 
❖ \_\_\_\_ properties
❖ No \_\_\_\_ properties
❖ Most commonly used in \_\_\_\_
A

conscious
antiemetic
amnestic
combo

34
Q

Oral Sedation:
Opioids

❖ Principle effect is \_\_\_\_
❖ Respiratory depressants
❖ Increase \_\_\_\_ muscle tone
❖ Poorly absorbed orally
❖ \_\_\_\_ disturbances
❖ Fentanyl (Actique) \_\_\_\_ (Demerol)
A

analgesia
smooth
GI
meperidene