7. Inflammatory bowel disease Flashcards
Layer of GIT wall?
Mucosa Muscularis mucosae Submucosa Submucosal plexus Circular later Myenteric plexus Longitudinal muscle Serosa
Aetiology of IBS?
• Multifactorial • Genetic factors • Autoimmune / Immune dysfunction • Environmental factors -External -Internal
5 main types of IBD?
- Ulcerative Colitis
- Crohn’s Disease
- Indeterminate colitis (either Crohn’s or ulcerative)
- Pseudomembranous Colitis
- Diverticulitis
Ulcerative colitis:
Which part of GIT inflamed?
Characteristics of inflammation?
Consequences?
Variable length of colon + rectum inflamed
If entire colon = PANcolitis
Inflammation:
- Contiguous
- Circumferential
- Superficial inflammation
Consequences:
- Anaemia due to iron deficiency
- Raised inflammatory markers
- Dehydration
Which is more common in spokers, UC or Crohn’s?
Crohns
Crohn’s:
Inflammation characteristics?
Signs/Symptoms?
Why does obstruction occur
Inflammation characteristics: • Characterised by inflammatory change anywhere in the GI tract • Discreet, focal ulceration • ‘Skip lesions’ • Terminal ileitis
S/S:
- Anaemia (absorption/ blood loss)
- Raised inflammatory markers
- Dehydration
Body trying to contain inflammation so fat wraps around the inflammation. Leading to the lumen being compressed
Crohn’s patients more likely to get.. than UC patients?
Fistula.
When ulcer permeate through bowel wall. Leading to faeces leakage and infections elsewhere in the body
Extraintestinal manifestations of Crohn’s?
- Inflammatory arthropathies
- Erythema nodosum (Crohn’s)
- Pyoderma gangrenosum
- Primary sclerosing cholangitis (UC)
- Iritis/Uveitis
- Aphthous stomatitis
What is diverticulitis?
In diverticular disease, small bulges or pockets (diverticula) develop in the lining of the intestine. Diverticulitis is when these pockets become inflamed or infected.
