7 Flashcards
from mesoderm or ectoderm proliferate and
aggregate;
Mesenchymeal (chondrogenic) cells
become round and enlarged and are now termed
Chondroblasts
secrete amorphous ground substance
Chondroblasts
to form the cartilage matreix
collagen
fibers
Originates from paraxial mesoderm, somatic mesoderm or ectomesenchyme
Bone
occurs in most bones of the axial skeleton and
appendicular skeleton.
Endochondral bone development
Cartilage model
ossification
chondroblasts secrete matrix to produce a cartilage model of the
future bone; the model is surrounded by
perichondrium
Addition of layers of bone matrix reduces the intertrabecular spaces and the cancellous
bone in the diaphysis is converted into a
Compact bone
creating
a smooth surface lubricated by
synovial fluid in the joint cavity
Osteoblasts also secrete calcium to the osteoid to
form
bone trabecula
me non-secretory and are now termed osteocytes.
Osteocytes present cytoplasmic processes that radiate into the matrix through tiny bone
channels called
Canaliculi
A bone with large intertrabecular spaces is classified as
cancellous or spongy bone
The intertrabecular spaces are occupied by blood-forming cells
(red bone marrow) and are also called
marrow spaces or marrow cavities
Joints must move during in utero and postnatal
development to prevent
ankylosis
Sclerotomal mesenchymal cells lateral to the thoracic vertebrae differentiates into
cartilaginous ribs
which are eventually destroyed and replaced by
bony ribs ( cancellous bone)
The sternum develops differently, from 2 longitudinal aggregations of somatic
mesaenchyme (somatic mesoderm) called
sternal bars
. The two (2) sterna bars fuse in the
ventral midline and become segmented to form
eight (8) sternebrae
lateral deviation of vertebral column
Scoliosis
sagittal deviation of vertebral column in a fixed position
Kyphosis
sagittal deviation of vertebral column in a fixed extended position.
Lordosis
abnormal twisting of the cervical vertebral column
Torticolis or wry neck
absence of vertebral arch
Spina bifida