67. HPV and Polyomavirus

Question 1

human polyoma virus epi?

Answer 1

• seroprevalence peaks in kids 5-9
• immunity wanes over time (81% seropositivity)
• respiratory transmission

Question 2

human polyomavirus structure?

Answer 2

• early coding region w/ T(transformational) proteins that bind to and inactivate p53 and Rb ptoein

assembled in nucleus, non-enveloped, smaller than HPV

Question 3

polyomavirus life cycle?

Answer 3

• JCV infects oligodendrocytes, astrocytes (lytic infection, myelin destruction)
• sxs usu subacute but incl discoordination, gait imbalance, cognitive dysfunction, vision probs
• occurs in immunosuppressed (HIV, cancer, transplant, mAB tx)

Question 4

polyomavirus clinical spectrum?

Answer 4

• primary infection usu asymptomatic
• disease in immunocompromised
• JCV = progressive multifocal leukoencephalopathy (PML) – CNS disease
• BKV = polyomavirus-assoc nephropathy (renal transplant), uretal stenosis & hemorrhagic cystitis – transplant patients