63: Thyroid/Antithyroid Drugs Flashcards
iodide uptake into thyroid gland by the…
sodium iodide symporter
oxidation of iodide to iodine
peroxidase mediated
iodination of tyrosine molecules within..
thyroglobulin molecule
“iodide organification”
can either be MIT or DIT
MIT + DIT =
DIT + DIT =
T3
T4
most thyroid hormone is released as…
T4
majority is bound to thyroxine-binding globulin in blood
without thyroid hormone bound..
receptor is bound to tyroid response element and corepressors to INHIBIT gene transcription
T3 will bind directly to monomer of TR but T4 needs to be converted to T3 (5’ deiodinase)
with T3 bound to TR, retinoid x receptor and TR form hetero-dimer and increase gene trx
hypothalamus releases TRH –>
pituitary gland –> TSH –> thyroid –> T3 and T4
high T3 and T4 ______ secretion of TRH and TSH
inhibit - negative feedback loop
high iodide concentrations _____ thyroid hormone synthesis
inhibit (short term)
low promote
impact of TH on sympathetics?
- increase B adrenergic receptors
- decrease alpha adrenergic receptors
impact of TH on growth and development?
- brain development, neurogenesis
- bone growth and skeletal maturation through activation of osteoblast/clast
impact of TH on thermogenics?
- increase energy consumption resulting in heat production
impact of TH on respiratory system?
- increase O2 consumption in most tissues, thereby increasing CO2 formation –> RR increases
impact of TH on CNS?
- rapidity of thinking and reasoning
- effect spinal cord synapses that control m. tone
impact of TH on GI?
increase secretions and motility
impact of TH on skin and hair?
- growth promotion of hair, skin, nails
- prevent accumulation of glycosaminoglycans in interstitial space