6.2 labour & puerperium? Flashcards

1
Q

what is the definition of labour?

A

onset of regular uterine contractions that lead to cervical effacement & dilatation with concomitant descent of the presenting part of the foetus through the enlarged cervix

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2
Q

Uterus becomes more sensitive to _______ as term approaches (37 – 42 weeks) → sensitivity is determined by the degree of ____________ (increased with twins, polyhydramnios) & the ____________ ratio

A

oxytocin;

myometrial stretch;

oestrogen : progesterone

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3
Q

The foetus controls the initiation of parturition/labour via increased secretion of CRH & ACTH:

• Increased foetal serum cortisol levels produces two effects:
o Increased ______________ production → formation of ________________ on the uterine muscle cell membrane
o Decreased placental ______________→ initiation of contraction

• Contractions increase pressure on the cervix → mechanoreceptor signals to brain → triggers maternal oxytocin secretion → uterine smooth muscle secretions 
o \_\_\_\_\_\_\_\_\_\_\_\_\_ (positive feedback loop): increased cervical pressure causes greater release of oxytocin → increased contractions
• After initiation of labour: cervical stretch & trauma to the decidua causes further release of \_\_\_\_\_\_\_\_\_\_\_\_ that augments the strength of contractions
Note: denervation of uterus does not stop normal onset of labour (controlled by hormones)
A

placental oestrogen;

oxytocin receptors;

progesterone production;

Ferguson reflex ;

oxytocin & prostaglandins

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4
Q

what occurs during the 1st stage of labour and how long does it occur for?

A
  • Less than 16h

- Onset of regular painful contractions leading to progressive dilatation of the cervix

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5
Q

what occurs during the 2nd stage of labour and how long does it occur for?

A
  • 1h (primigravid); significantly shorter if multigravida

- Full dilatation of the cervix (10cm) to delivery of the foetus

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6
Q

what occurs during the 3rd stage of labour and how long does it occur for?

A
  • 10 – 60 min

- Delivery of the foetus to delivery of the placenta

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7
Q

[1st stage of labour (latent phase)]

Cervix effaces & dilates slowly for the ______________ :
• Uterine contractions are initially relatively painless (occur at intervals of ______________ min) & do not distress the patient
• Contractions increase in frequency & intensity as labour progresses
• May take several hours in primiparous women

A

first 3cm;

5 – 10

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8
Q

[1st stage of labour (active phase)]

Commences when cervix is ______________ (rate of 0.5 – 1cm/h in nulliparous women; 2cm/h in multiparous women):
• 3 – 4 strong contractions every 10 min (1 contraction every __________) lasting ____________ → assessed by palpation of the uterus
• Foetal head descends further into the pelvis & ___________
• Contractions become increasingly painful & many women have the desire to push → assess cervix to determine full dilatation

A

3 – 4cm dilated;

3 – 4 min;

40 – 50s;

flexes

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9
Q

Foetal asphyxia: uterine contractions causes ______________

  • Results in a ____________ in the 1 st stage that continues until full cervical dilatation –> accelerates once maternal bearing down (pushing) commences
  • Very prolonged 2nd stage thus results in some degree of foetal asphyxia
  • Management: auscultation of foetal heart (to determine changes suggestive of foetal hypoxia as acid base changes activates the ANS to cause altered foetal heart pattern) –> expedite 2nd stage via _______________
A

mild foetal hypoxia;

slow decline in foetal pH;

instrument delivery

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10
Q

[2nd stage of labour
After full cervical dilation, the foetus progresses through the maternal pelvis due to uterine contractions & maternal expulsive forces (increases intrauterine pressure to 100 – 120mmHg):
1. Foetal head engages into the pelvis in the ______________ position (transverse diameter of inlet > AP diameter)

  1. Head flexes → descends & _____________ → occiput lies anteriorly under the maternal pubic symphysis
    • Crowning is the ___________________ → foetal parietal bones become visible
  2. Maternal expulsive forces propels the foetal head → head extends & delivers (birth attendant applies gentle pressure on the head to maintain flexion)
A

occipito-transverse (OT);

internally rotates;

appearance of the foetal head at the perineum

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11
Q

Episiotomy: cut in the perineum to enlarge the vaginal introitus to allow easier delivery (performed under LA unless _________________ has already been given)
• As the foetal head delivers, the maternal perineal tissue stretches and may tear → involves the anal sphincter & rectum (causing faecal incontinence)
• ______________ is preferable to midline episiotomy

A

epidural analgesia;

Right mediolateral episiotomy

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12
Q

[3rd stage of labour]

The third stage of labour is characterised by placental delivery (takes 10 – 60 min), which is achieved by strong uterine contractions:
• Uterine contractions cause reduction of internal surface area by more than 50%
• Placenta has a fixed mass & cannot reduce surface area (adherent to uterine wall)
• Bleeding from the spiral arterioles is revealed → placental separation is apparent by a __________________

A

gush of blood & lengthening of the cord

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13
Q

Active management of 3rd stage: to prevent postpartum haemorrhage from prolonged physiological placental separation
• Offered to all women during childbirth
• Uterotonic drug: given following foetal delivery → causes _______________
• Controlled cord traction (_______________ technique): apply firm traction to umbilical cord with one hand & suprapubic counterpressure with the other (see right)

A

uterus to contract strongly (aids in separation);

Brandt-Andrews

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14
Q

how does rupture of membranes cause loss of foetal blood flow?

A

Reduced volume of amniotic fluid around the baby causes loss of the cushioning effect around the foetus:
• Uterine contractions exert direct pressure on the foetal head during descent → reduced cerebral blood flow
• Most commonly in the later part of the 1st stage of labour

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15
Q

how does direct cord pressure cause loss of foetal blood flow?

A

Compression of the cord leads to decreased flow to the foetus

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16
Q

The rise in intra-myometrial pressure during uterine contraction causes: 1. Trapping of large pool of oxygenated blood (~500ml) in the placenta (due to cutting off of the ___________________ while arterial blood flow continues)
2. Arterial blood flow ceases as intrauterine pressure continues to rise (≥30mmHg) → maternal part of placenta becomes a closed system
3. Foetal circulation continues extracting oxygen from trapped maternal blood → oxygen supply declines steadily with time
4. Pressure falls below 30mmHg as the contraction ends → blood flow resumes and oxygen-depleted blood drains from the _______________
5. Oxygen is only restored to the foetus ________________ → foetus needs to undergo anaerobic metabolism (causes small decline in foetal pH)
o Foetuses with ________________ (e.g. prematurity, growth restriction, maternal pre-eclampsia, placental abruption, hyperstimulation of the uterus) may be more compromised in labour

A

low-pressure venous drainage ;

intervillous space ;

~1 min after the contraction has worn off;

low metabolic reserve

17
Q

Labour is monitored using a partogram (graphic display to assess overall progress in labour & changes in maternal & foetal parameters). What is being monitored constantly?

A
  • Maternal details
  • Maternal temperature, pulse and blood pressure
  • Foetal heart rate
  • Amniotic fluid colour
  • Cervical dilatation
  • Descent of foetal head (station)
  • Drugs (including syntocin and epidural)
  • Contraction rate
  • Maternal urine output
18
Q

Foetal monitoring entails the assessment of the foetal heart during labour to identify any changes that may suggest foetal hypoxia → urgent intervention if necessary:
• Frequency: _____________ (in 1st stage), __________________ (in 2nd stage)
• Method: Pinard stethoscope or US foetal heart rate monitor (for low risk women), continuous heart rate monitoring with cardiotocograph (for high risk women)
o Cardiotocograph monitors both _____________

A

every 15 min;

after every contraction;

foetal heart rate & uterine activity

19
Q

The puerperium is the time during which anatomical, physiological, biochemical changes of pregnancy return to the non-pregnant state:
• Occurs after the ____________ until _____________
• Associated with maternal emotional & psychological changes

A

3rd stage of labour;

6 weeks postpartum

20
Q

[Puerperium: Size of uterus]

Involutes from ~1kg at term to ~50 – 100g in puerperium because
• Oxytocin stimulates ______________ → breastfeeding is associated as it causes oxytocin release
• Decreased size of myometrial cells due to increased activity of
_________________

*Progress: level of __________(soon after birth) → fundus no longer palpable (by 10 – 14 days) → ~normal size (by 6 weeks)
• Uterus remains slightly enlarged due to permanent increase in number of cells & elastin in myometrium, vessels, connective tissues

A

uterine contractions (may be painful);

uterine collagenase & release of proteolytic enzymes;

umbilicus

21
Q

[Puerperium: Return of menstruation]

Depends on whether the woman is lactating:
• Non-lactating: return of menses by ____________ & ovulation by____________
• Lactating: by 6 months (lactational amenorrhoea)

A

6 weeks;

90 days

22
Q

[Puerperium: Placental site]
After delivery: contracts after placental separation in the decidual layer to 50% of its original area → occludes ______________ to reduce risk of PPH
• Placental bed is invaded by macrophages & other inflammatory cells, causing it to shed its superficial layers

By 7 – 10 days: re epithelialisation of uterine cavity (except for placental bed which does not fully regenerate until 6 weeks postpartum)
• _______________ are shed
• Lochia (uterine discharge): initially ___________ & becomes _______________ → lasts up to 8 weeks
o Lochia remaining red for >10 days is suggestive of improper placental site involution

A

spiral arterioles;

Trophoblast & decidua;

blood-tinged;

serous and pale

23
Q

[Puerperium: Cervix involution]
• Immediately after delivery: ______________
• By 1 week: involution to ___________
• By 14 days: internal os has closed, external os is a ___________

A

enlarged & haemorrhagic;

1cm diameter;

transverse slit

24
Q

[Puerperium: vaginal involution]
• By end of 1st week: rapid healing of perineum
• By end of 3rd week: regains _____________
• _____________ are the torn hymnal remnants

A

tone & rugal pattern;

Carunculae myritiformis

25
Q

[Puerperium: pelvic floor muscles ]

Tone is gradually restored to the voluntary muscles of the pelvic floor:
• Any residual laxity predisposes to __________________

A

pelvic organ prolapse

26
Q

In the puerperium, there may be trauma to the urinary tract & diuresis:
• Trauma: _____________ of the bladder base (if labour is prolonged, baby is large, instrumental delivery is performed) → _____________ → difficulty voiding
o Ensure bladder is not over-distended (aggravates damage)
• Diuresis: significant fluid shift (from ___________ to _________-) in the first few days after birth
o Ureters can remain dilated up to 3 months after pregnancy

A

oedema & bruising;

detrusor denervation;

extracellular space to intravascular component

27
Q

how does coagulation change during puerperium?

A

During pregnancy: increase in clotting factors I, II, VII, VIII, IX, X
• After placental separation: clotting factors & platelets are consumed at the placental site
• During puerperium: increased risk of DVT/PE (worse

28
Q

how does Red cell volume change during puerperium?

A

decreases by ~14% during delivery & resolves by 8 weeks postpartum

29
Q

how does white cell volume change during puerperium?

A

increases in labour (usually neutrophils)

30
Q

how does plasma cell volume change during puerperium?

A

may increase in the 1st 3 days postpartum (due to fluid shifts into the intravascular compartment) & resolves by the end of puerperium

31
Q

how does CO change during puerperium?

A

remains elevated with stroke volume in the 1st hour & completely resolves by 6 weeks

32
Q

how does bp change during puerperium?

A

returns to normal early in puerperium

33
Q

Progesterone induces reduced gut motility during pregnancy:

• Constipation may be common in the 1st few days postpartum if the mother is __________________

A

dehydrated and has low oral intake

34
Q

how does hCS/ hPL levels change during puerperium?

A

Undetectable levels by day 1 postpartum

35
Q

how does hCG levels change during puerperium?

A

Levels of <100 by day 7 postpartum (half-life 9h)

36
Q

how does progesterone levels change during puerperium?

A

Below luteal levels by day 3 postpartum

37
Q

how does prolactin levels change during puerperium?

A

Gradual rise during pregnancy:
• Non-lactating women: gradual decline over 2 weeks
• Lactating women: increases due to nipple stimulation during breastfeeding → produces anti-gonadotrophic effect at the pituitary level → disturbances in LH release

38
Q

how does TSH levels change during puerperium?

A

Very low in the 1st 2 weeks and gradually increases thereafter