Sketchy Pharm: Trimethoprim/Sulfamethoxazole Flashcards

1
Q

What are the precursors for dihydropteroate synthase?

A

P-amino benzoic acid and pteridine

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2
Q

What does sulfamethoxazole inhibit the synthesis of?

A

Purines

Like the purine-shaped cookies being handed out by PApA Bear.

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3
Q

A common usage of Bactrim is _________________.

A

UTIs and prostatitis from Gram-negative organisms

(Think of the guy waiting in line at the red portapotty with the bladder-shaped beverage and the little kid putting an egg in the rear of his pants.)

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4
Q

What two bacteria are represented on the purple fence?

A

MRSA (pharaoh spray painting “No Mercy”) and Nocardia (kid spray painting filamentous branches

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5
Q

Bactrim is used to prophylactically treat _______________.

A

Pneumocystis jirovecii in AIDS patients with CD4 counts less than 200 and Toxoplasmosis in AIDS patients with CD4 counts less than 100

(Think of the old man with the ping pong paddle at the house #200 and the crazy cat lady at house #100.)

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6
Q

Which drugs treat Toxoplasmosis gondii in AIDS patients?

A

Pyrimethamine/sulfadiazine, a similar combination to Bactrim

(Think of the DYed eggs near the Gandhi cat and the PYRamid hat on the cat lady.)

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7
Q

What are some side effects of Bactrim?

A

Teratogen (in the first trimester)
Pancytopenia and megaloblastic anemia

(Think of the tarantulas on the first house and the empty PAN of cookies. Also, the fireworks symbolize megaloblastic anemia.)

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8
Q

What side effects can be caused by sulfonamides?

A

Red, pruritic rash (kid in devil costume)
SJS (kid in devil costume taking mask off)
Anemia in those with G6PD deficiency (watermelon with a bite missing)
Type IV renal tubular acidosis –hypoaldosteronism (4 test tubes in a K shape)
Interstitial nephritis (kidney-shaped trash bag)
Photosensitivity (mom taking kids’ photo)
Kernicterus in kids (candy-corn kid)
Displacing drugs from albumin (mom with ALBUM of photos spilling)
CYP inhibition (broken down car)
Lupus (wolf mask on MJ)

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