What are the second-generation (atypical) antipsychotics?

Quetiapine, olanzapine, risperidone, and aripiprazole (QUiET, OnLy whISPERIng AllOwed) Ziprasidone, clozapine ( ZIPper on the woman's dress; CLOset)

What is the mechanism by which second-generation antipsychotics work?

They, like the first-generation antipsychotics, block D2 receptors in the mesolimbic system. Additionally, however, they also block 5-HT 2A receptors. (Think of Dalí with the double dope-rope and the smiley face with the slice taken.)

What disorders other than schizophrenia can be treated with SGAs?

OCD (the guy obsessively adjusting the painting), treatment resistant depression (the guy struggling with the wine bottle), Tourette's (elephant marionette)

Other than blocking 5-HT 2A receptors and D2 receptors, many SGAs also block _________.

H1 histamine receptors and alpha-1 (the guy swatting the bee painting and the extinguished alpha candle)

Which SGA has the greatest antimuscarinic ability?

Clozapine (the clozapine closet blocking the Alice in Wonderland painting)

One of the big side effects of SGAs that is not associated with FGAs is ____________.

weight gain (the bloated Dalí painting) and metabolic syndrome (diabetes – candy – and dyslipidemia –butter); ziprasidone has the lowest risk (just think of that sleek black dress)

What are the side effects specific to clozapine?

Agranulocytosis Myocarditis Lowered seizure threshold (failing grains of sand, heart on the beach, and shaking alarm clock)

Most of the SGAs cause fewer extrapyramidal side effects than the FGAs. Which, however, still causes some?

Risperidone (the guy whispering to the extrapyramidal-hat-wearing patron getting kicked out of the gallery); risperidone can also cause prolactinemia and neuroleptic malignant syndrome

Sketchy Pharm: Second Generation Antipsychotics Flashcards by Billy Tran

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Sketchy Pharm: Second Generation Antipsychotics Flashcards

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