What is a short-acting benzodiazepine?

Oxazepam (the running bull, charging fast)

________ metabolism accounts for degradation of all benzodiazepines.

Hepatic (recall the ox with the liver spot)

The benzodiazepines activate the ___________ receptor.

GABA A (think of the Cab-A cab)

What else binds to the GABA (A) receptor?

Alcohol (hence, benzodiazepines are given in alcohol withdrawal) Barbiturates Phenytoin Neurosteroids

Benzodiazepines used alone can provide ___________ sedation.

conscious (such as for a colonoscopy – think of the patient with the lite drink representing lite anesthesia)

What is a major risk of benzodiazepine use?

Tolerance! Using anything that stimulates GABA channels will cause them to down-regulate. Thus, you will need more GABA-channel inducer to get the same effect.

What is the antidote for benzodiazepine overdose?

Flumazenil (GABA A antagonist) – think of the "fluffy muzzled dog" blocking the delivery boy trying to get to the cab; its use remains controversial, though, because it has been known to induce seizures in those addicted to benzodiazepines.

Sketchy Pharm: Benzodiazepines and Flumazenil Flashcards by Billy Tran

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Sketchy Pharm: Benzodiazepines and Flumazenil Flashcards

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