What is the difference between norepinephrine and epinephrine?

Epinephrine acts as a hormone while norepinephrine acts as a neurotransmitter.

Alpha-1 activation leads to a _____________ in blood pressure.

dose-dependent increase (because of the vasoconstriction in veins and arteries – think of the red leashes)

Alpha-1 activation leads to what ophthalmologic and GI/GU effects?

Mydriasis (constriction of the pupillary dilator muscle) and urinary/fecal retention (constriction of the urethra and anal sphincter)

Describe the role of alpha-2 activation.

It decreases the sympathetic response; it is a Gi protein that decreases cAMP in presynaptic terminals – thus preventing the release of more norepinephrine – and decreases insulin release in the pancreatic islet cells (think of the rolled up mat and tent and power sources). Also, it decreases lipolysis (think of the fire being extinguished with the pig over it) and decreases aqueous humor production (think of the eyeball hat being poured out – brimonidine).

What adrenergic receptor mediates renin release?

Beta-1 (the girl standing next to the fire hydrant – representing increased cardiac output)

What receptor mediates vasodilation?

Beta-2 (the girl with the beta-2-tuba with dilated, loose sleeves)

What receptor induces lipolysis?

Beta-2 (the pig roasting next to the beta-2-tuba

Beta-2 activation leads to what in the liver?

Gluconeogenesis (the girl roasting marshmallows over the beta-2 fire)

How does beta-2 activation affect potassium levels?

It decreases K, because it induces insulin release

What receptors does norepinephrine activate?

Primarily alpha, but also some beta-1; think of the north-facing scout with the beta-1 bugle

Increased pulse pressure is a side effect of which kind of adrenergic receptor activation?

Ones that have beta-1 (inotropic agents) and beta-2 (vasodilatory)

Dobutamine activates ______________.

beta-1 (do-beta-one = dobutamine)

What drugs (and what targets) are used to prevent premature labor?

Terbutaline (do not disturb) and ritodrine (I DReam of band camp)

At low doses, epinephrine primarily affects ____________; at high doses it affects __________.

beta receptors; alpha receptors

Sketchy Pharm: Sympathomimetics Flashcards by Billy Tran

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Sketchy Pharm: Sympathomimetics Flashcards

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