6. mila

Question 1

What is the main differences between necrosis and apoptosis in terms of 1) morphology, 2) stimulus, 3) side-effects for the surrounding tissue?

Answer 1

1)
2)
3)

Question 2

What are the key elements involved in the intrinsic pathway of apoptosis?

Answer 2

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Question 3

What are the key elements involved in the extrinsic pathway of apoptosis?

Answer 3

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Question 4

At which point do the two pathways converge?

Answer 4

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Question 5

DNA damage leads to apoptosis through which of the two main routes?

Answer 5

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Question 6

Why does cytochrome c need to be present in the cytosol in order for the mitochondrial pathway to proceed?

Answer 6

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Question 7

What are the key components of the apoptosome and what is the function of this structure?

Answer 7

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Question 8

What is the difference between an initiator caspase and an effector caspase in terms of function?

Answer 8

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Question 9

What is the equivalent of the apoptosome in the extrinsic pathway?

Answer 9

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Question 10

What protein family is always involved in apoptosis?

Answer 10

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Question 11

What catalytic type are the protein family involved in apoptosis?

Answer 11

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Question 12

What is their (proteins used in apoptosis) basic requirement in terms of amino acid residues surrounding the scissile bond in the substrate?

Answer 12

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Question 13

There is at least one example of caspase activation through a different type of protease. What is this called and under which circumstances does it enter the cell?

Answer 13

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Question 14

What are the two main activation platforms for initiator caspases in apoptosis?

Answer 14

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Question 15

What domains are found in both death receptors and the adaptor protein FADD and what is the relevance of this?

Answer 15

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Question 16

What domains are found in both FADD and some initiator caspases and what is the relevance of this?

Answer 16

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