6. Gonadotrophins responsive conditions

Question 1

Cetrorelix and Ganirelix function

Answer 1

A gonadotropin-releasing hormone antagonists which inhibit the gonadotropins (LH and FSH) .

Used to treat infertility in assisted reproductive techniques

Question 2

Breast pain (mastalgia) treatment

Answer 2

Once serious underlying cause has been ruled out:

mild, non-cylical breast pain: simple analgesics

moderate-severe pain OR cyclical pain OR symptoms that persist for over 6 months: Danazol, Tamoxifen used adjuctively

Recommend reduction in dietary fat and withdrawal of oral contraceptive

Question 3

Gonadorelin analogues function

Answer 3

Triptorelin, leuprorelin and goserelin are gonadotrophin-releasing hormone (GnRH) analogues.

Used to treat endometriosis, infertility, anaemia due to uterine fibroids (with iron suplplementation), breast cancer, prostate cancer