6. Enzyme inhibitors

Question 1

Competitive inhibitors

Answer 1

has chemical structures resembling substrate

Question 2

Allosteric sites

Answer 2

-far from active site
-allows allosteric ligand binding at all time (non-competitive)
-allow binging after substrate binds in active site (uncompetitive)

-conformational changes occur after binding, causing enzyme to be less effective

Question 3

IC50 values

Answer 3

–the conc of inhibitor that causes 50% inhibition of the enzyme

Question 4

Drugs as a competitive inhibitor

Answer 4

-side effects(interact w/ sim enzymes)

-resistance(target organism mutates enzyme/ degrades or detoxifies drug)

-bioavailability(drug doesn’t reach intended site/degraded/excreted)

Question 5

Biological feedback

Answer 5

substrate acts as inhibitor, so conc of substrate in cell is not too high/ more than required by cell