6. Endocrine Ds Flashcards

1
Q

adrenal glands secrete what

A

cortisol, epi, NE, aldosterone, and adrenal androgens

(sex hormones and catecholamines)

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2
Q

adrenal glomerulosa

A

aldosterone

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3
Q

adrenal fasciculata

A

cortisol (glucocorticoid)

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4
Q

adrenal reticularis

A

androgens

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5
Q

NE and Epi actions

A

fight or flight - stress response

increase Bp, peripheral resistance, cardiac output

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6
Q

hyperadrenalism is what

A

increase of aldosterone, cortisol, androgen, estrogen isolated or in combo

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7
Q

hyperaldosteronism

A

HTN, hypokalemia, edema

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8
Q

glucocorticoid xs

A

is high levels of cortisol
and the MOST COMMON

(Cushing ds and syndrome)

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9
Q

CUSHINGOID memonic

A

signs and symptoms that as associated with cushing ds

C-cataracts
U- ulcers
S- striae and skin thinning
H- HTN and hirsutism
I- Immunosuppresion and infections
N- Necrosis of femoral heads
G- Glucose elevation
O- Osteoporosis and obesity
I- Impaired wound healing
D- Depression and mood changes

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10
Q

cushingoid moon face is a sign of

A

cushing ds or syndrome

not necessarily specific for cushings though.

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11
Q

why is cortisol used

A

it is used to decrease inflammation

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12
Q

bexamethasone

betamethason are what type of drugs

A

long-acting glucocoritcoids

used for oral ulcerations ( dexamethesome)

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13
Q

prednisolone

triamcinolone

methylprednisolone are what type of drugs

A

intermediate acting glucocorticoids

used topciallly (methyprednisolone)

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14
Q

primary adrenal insufficiency is what

A

addisons ds
increase ACTH decrease Cortisol.

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15
Q

what is this

A

cutaneous findings in addisons ( so primary adrenal insufficiency)

hyperpigmentation of skin and mucous membrance but they’re iregullarly shaped. It’s a variation of normal but could be addisons too.

hyperpigmentation and andrenal crisis do not usually ocur or are less likelly to occur in the secondary and teritary insufficiencies.

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16
Q

secondary adrenal insufficiency

A

decrease of cortisol and decrease of ACTH, aldosterone is unchaged.

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17
Q

tertirary adrenal insufficiency

A

most commonly a result of chronic exogenous steroid use

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18
Q

impaired would healing can be a consequence of both ___ and ____

A

hyperadrenalsim and adrenal insufficiency

19
Q

signs of an adrenal crisis

A
  • hypotension - monitor BP (vasopressors, pt position, fluid replacement)
  • abdominal pain
  • myalgia
  • fever
  • supplement with 100mg of hydrocoritsone and send to the ER
20
Q

3 hormones of the thyroid procedures

A
  • T3
  • T4
  • Calcitonin
21
Q

what is a thyroid storm

A

during a hyperthyroidism event

the pts will have fever, confusion, dehydration and eventually death if left untreated. This is thyroid storm

22
Q

in hyperthyroidism you have __ free T4 and ___ TSH

A

increase free T4 and decrease TSH

23
Q

hypothyroidism is __ free T4, ___ TSH or ___ TSH

A
  • decrease of free T4
  • increase of TSH

or increase of TSH

24
Q

hyper- thyroid dental implications

A

increase in peridontal bone loss

increase susceptibility to caries

25
Q

hypo-thyroid dental implications

A
  • delayed tooth eruption and altered bone formation
  • macroglossia
  • dysgeusia and burning mouth
  • salivary gland enlargment
  • oral lichen planus
26
Q

pts with both hyper and hypo thyroidism are more susptible to what

A

infections so tx aggresively just do not over tx.

27
Q

if a pt is having a thyrotoxic crisis/storm for hyperthyroidism what should you administer

A

cpr and vital signs

ice or wet packs

administer hydrocortisone 100 to 300 mg

IV glucose

Administer propylthiouracil

send to ED

28
Q

if a pt is having a myxedema coma for hypothyroidism what should you administer?

A

CPR and vital signs

conserve body heat - blanket

administer hydrocortisone 100 to 300 mg

IV saline and glucose

Administer thyroxine

Send to ED

myXedema with thyroXine and… hydrocortisone(the same for hyperthry)

29
Q

should you give care to pts with uncontrolled or poorly controlled hyper or hypo thyroidism

A

no… only if it is under control.

Too many risk factors of a thyrotoxic storm and/or myxedema coma

30
Q

drug interactions/side effects seen in hyperthyroidism

A
  • caution w aspirin, NSAIDS (can incr. T4)
  • contraindicated to use ciprofloxacin because it decreases the absorption of thyroid hormone
  • avoid LA with epi and gingival retraction cord w epi
31
Q

drug inteactions/side effects in hypothyroidism

A
  • avoid CNS depressants (narcotics, babituates, sedatives)
  • Cytochrome p450 inducers (phenytoin, carbamazepine, and rifampin) should be avoided bc it increases metabolism of levothyroxine.
32
Q

pancrease hormones

A

insulin

glucagon

somatastatin

33
Q

diabetes is due to

A
  • lack of beta cell pancreatic production of insulin
  • results in undernourished tissues which have systemic effects.
34
Q

type 1 is due to

A

the destruction of pancreatic beta cells –> insulin deficiency

35
Q

type 2 diabetes is due to

A

pancrease produces insulin but it is in low titers or it doesnt work properly

majority of diabetics.

36
Q

order of stability of the tests for DM

A

hemoglobin A1C –> fasting plasma glucose –> oral glucose tolernace test

37
Q

DM oral implications

A
  • xerostomia/dry mouth
  • oral burning (diff from burning mouth, secondary)
  • infections (bacterial, viral, fungal)
  • poor wound healing
  • increased caries
  • increased severity risk of periodontal ds
38
Q

at what HbA1c and glucose readings do we defer tx

A

HbA1c 8% or higher

glucose is less than 70 or more than 200

39
Q

what are the emergency dental tx during pregnancy

A
  • provided as needed
  • pain control and elimination of infections should be preformed, or else it stresses the mother and endargers the fetus
  • untx dental infections may pose a risk to the devloping fetus –> fever and sepsis may precipitate a spontaneous abortion

-

40
Q

supine hypotension syndrome

A

pregnant pt cannot lie on their back or else it will compress the inf vena cava and affect venous return too.

41
Q

which sedation should be used on a preg pts

A
  • no pharmacologic sedation is preferred

if ABSOLUTLEY necessary then nitrous oxide for less than 30 mins and with at least 50% oxygen.

42
Q

Which two antibiotics are contraindicated in preg pts

A

tetracycline and doxycycline CONTRINDICATED

teratogenic

43
Q

what is the max permissible dose for occupational

A

1 mSv/yr

avg denetal is 0.2 mSv/yr

44
Q

oral findings in a pregnant pt

A
  • mild inflammation to severe overgrowth due to hormonal increase
  • tooth mobility may be present
  • pyogenic granuloma pregnancy tumor it is reacting to something irritating the tissue overgrowth.