6. COPD Flashcards

1
Q

What can lung conditions cause the airways to become?

A

Inflamed and narrowed or filled with phlegm hence its harder for air to move in and out of the lungs.

Can make the lungs stiff and less elastic so it’s harder for them to expand and fill with air.

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2
Q

Lung conditions that cause long-term (chronic) breathlessness:

A
  • COPD
  • Obesity
  • interstitial lung disease (ILD), including pulmonary fibrosis and sarcoidosis
  • bronchiectasis
  • industrial or occupational lung diseases such as asbestosis, which is caused by being exposed to asbestos
  • lung cancer
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3
Q

Lung conditions that cause short-term (acute) breathlessness:

A
  • flare-up of asthma or COPD
  • PE or blood clot on the lung
  • lung infection such as pneumonia or TB
  • pneumothorax or collapsed lung
  • build-up of fluid in your lungs or the lining of your lungs – this might be because your heart is failing to pump efficiently or may be because of liver disease, cancer or an infection
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4
Q

Explain how a heart condition can cause long-term (chronic) breathlessness.

A

Can be due to problems with the rhythm, valves or cardiac muscles of the heart. Heart can’t increase its pumping strength in response to exercise, or the lungs become congested and filled with fluid often worse when supine (so when sleeping).

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5
Q

Heart conditions that cause acute breathlessness include:

A

Heart attack (MI)

An abnormal heart rhythm.

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6
Q

Explain how anxiety can cause SoB.

A

Feeling SoB when anxious or afraid is a normal response to stressful situations; the body is preparing for action as you get more anxious, you may start to breathe faster and tense your breathing muscles. Physical health can also impact mental health, especially if living with a lung condition you might get anxious if you don’t feel in control of your condition

If you have a lung condition, you may have symptoms that make you feel anxious. Sometimes the symptoms of lung conditions e.g. breathlessness, tightness in your chest or getting tired very easily are similar to feelings of anxiety.

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7
Q

What is a panic attack?

A

When the body’s normal response is exaggerated, you get a rapid build-up of physical responses; breathing quickens and your body also releases hormones so your heart beats faster and your muscles tense

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8
Q

In addition to feeling you can’t breathe during a panic attack what else happens?

A
  • have a pounding heart
  • feel faint and sick
  • sweat
  • have shaky limbs
  • feel that you’re not connected to your body
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9
Q

What happens if you breathe too quickly in response to panic attack?

A

You may breath in more oxygen than your body needs → Called hyperventilation

When you do this, the delicate balance of the gases in your lungs is upset. An amount of carbon dioxide normally stays in the blood. If you breathe in too much air too often, the carbon dioxide is pushed out through the lungs and this affects the messages the brain receives to tell you to breathe.

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10
Q

Explain why being unfit or having an unhealthy weight can lead to SoB.

A

When we are unfit, our muscles (including respiratory muscles) get weaker. Weaker muscles need more oxygen to work, so the weaker our muscles, the more breathless we feel.

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11
Q

Being an unhealthy weight can also contribute to make us feel breathless. List all the reasons why.

A

If you’re underweight, your respiratory muscles will be weaker.

If you’re overweight, it takes more effort to breathe and move around.

Having more weight around the chest and stomach restricts how much your lungs can move.

People who are a BMI of 25 or more are more likely to get breathless compared to people with a healthy weight.

People who are severely overweight can develop obesity hypoventilation syndrome; when poor breathing leads to lower oxygen levels and higher carbon dioxide levels in their blood.

Maintaining a healthy weight may help you to manage your breathlessness better and be more active.

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12
Q

Other causes of long-term (chronic) breathlessness.

A
  • smoking
  • conditions that affect how your muscles work, such as muscular dystrophy, MG or motor neurone disease
  • postural conditions that alter the shape of your spine, and affect how your ribs and lungs expand - for example scoliosis and kyphosis
  • anaemia
  • kidney disease
  • thyroid disease
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13
Q

What are the barriers to diagnosing breathlessness?

A
  • think breathlessness is as a normal part of ageing, so don’t tell their doctor
  • feel responsible for causing their illness and don’t feel they deserve help
  • not realise they can get any help for their breathlessness
  • not actually feel out of breath when they see their doctor (would be sitting down and may have only walked a short distance), so may forget what their breathlessness feels like and find it hard to describe
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14
Q

What can patients do to help a doctor diagnose breathlessness?

A
  • Use an online breath test to find out if your breathlessness is something to get checked out with your doctor.
  • Bring someone with them who can help describe their breathlessness
  • think about how they will be describing their breathlessness in advance of seeing a doctor e.g. what they used to be able to do but can’t any more, what people of their age around them do that they find difficult and what their personal goals are for their day-to-day activity
  • use local landmarks such as bus stops, shops and hills to help you describe these things
  • record the sort of activities that make them out of breath to show their doctor what it looks or sounds like
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15
Q

What tools can doctors use to diagnose breathlessness?

A
  • Use the MRC breathlessness scale
  • Ask questions about breathlessness
  • Do some tests to help diagnose what’s causing the breathlessness
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16
Q

MRC Breathlessness Scale

A
  1. Not troubled by breathlessness
  2. Breathlessness on vigorous exertion - e.g. running
  3. Breathless walking up slopes
  4. Breathless walking at normal pace on flat; having to stop from time to time.
  5. Stopping for breath after a few minutes on the level.
  6. Too breathless to leave the house.
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17
Q

Questions Dr’s may ask about breathlessness?

A

Duration

Onset

Frequency

Pattern

Time

Relieving factors e.g. lying flat

Exacerbating factors e.g. pollen, pets, medication

Smoking

Coughing/phlegm

Chest pain, palpitations, ankle swelling

Normal activity levels

Occupation

Whether breathlessness is related to certain times at work

History of heart, lung or thyroid disease, or of anaemia

Family history of breathlessness

Lifestyle changes made due to breathlessness (if any)

Feeling worried, frightened, depressed or hopeless

Coping mechanisms

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18
Q

What tests may help doctors to help diagnose the cause of breathlessness?

A

Breathing and lung function tests

Respiration rate (breaths per min)

Chest auscultation (listening)

Look and feel how chest moves during breathes

HR and rhythm

Check if fluid is building up in ankles or lungs

BP and temperature

Check height, weight, waist and BMI

Examine head, neck and armpits to see if lymph glands are swollen

Inspect eyes, nails, skin and joints

Check blood sats with a pulse oximeter

If there are signs that patient is anxious/depressed, a short questionnaire

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19
Q

Possible additional tests at GP surgery, local testing centre or hospital

A

CXR- chest X-ray

Spirometry test

ECG - if breathlessness is intermittent, wear a portable recorder for 24 hours or 7 days to record heart’s electrical activity

Echocardiogram - this is a non-invasive ultrasound of heart which can tell how well it’s working

Blood tests to detect anaemia, allergies or any thyroid, liver, kidney or heart problems

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20
Q

What is SoB on exertion?

A

When you have additional requirements on top of your baseline needs, and don’t acquire enough oxygen to meet the needs.

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21
Q

Differential diagnoses that can present with SoB on exertion.

A
  • Respiratory
    • Asthma
    • COPD
    • Pulmonary fibrosis (lung tissue becomes fibrotic and scarred)
    • Lung cancer
    • PE
    • Pneumothorax
    • Lower RTI
  • CV
    • Congestive heart failure (fluid builds up within the heart and causes it to pump inefficiently)
    • Pulmonary oedema (fluid collects in the numerous air sacs in the lungs, making it difficult to breathe -mainly caused by heart problems)
    • Valvular defects
    • Acute coronary syndrome
    • Anaemia
    • Renal or heart failure
    • Deconditioning (being unfit/significant loss in muscle mass -affects heart and respiratory muscles)
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22
Q

Questions to ask Mr. Craven to help hone in differential.

A
  • how long has he had symptoms for (to differentiate acute e.g. infection, pneumothorax and chronic e.g. COPD, asthma, pulmonary fibrosis)
  • is he waking up at night; left HF results in back clog of blood in lungs (pulmonary oedema), lying down is worse as fluid remains around lungs instead of being drained away when standing
  • chest pain; causes acute coronary syndrome, pneumonia, heart attack, angina, pneumothorax, PE
  • cough e.g. infection
  • times of breathlessness (asthma symptoms are typically worse in the morning)
  • any change in physical activity
  • history of cancer
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23
Q

Things to look out for on examination to help hone in differential of Mr. Craven:

A

Specific lung sounds e.g. healthy chest=smooth/lamina flow, wheezing=turbulent flow, fluid produces crackle.

Specific heart sounds e.g. look out for murmur.

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24
Q

Investigations to carry out on Mr. Craven:

A
  • spirometry
  • ECG
  • CXR
  • bloods
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25
Q

What is FVC?

A

Is the amount of air that can be forcibly exhaled from your lungs after taking the deepest breath possible.

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26
Q

What is FEV1 (forced expiratory volume in 1 second)?

A

Maximum amount of air that the subject can forcibly expel during the first-second following maximal inhalation.

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27
Q

What is the normal FEV1/FVC ratio?

A

70-80%

28
Q

Restrictive Diseases

A
  • Mechanism
    1. Lung capacity is restricted, so FVC is lower
    2. If airways are unaffected, FEV1 will be normal
    3. Therefore FEV1/FVC ratio could be slightly increased
    OR
    1. If FEV1 is proportionally lower, FEV1/FVC ratio could be normal
    2. Won’t necessarily affect rate of flow but affects lung volume
    3. Can’t fully fill lungs
  • Causes
    • scoliosis
    • interstitial lung disease e.g. pulmonary fibrosis; alveoli are less stretchy so can’t get as much air in
    • MD
    • obesity
    • sarcoidosis, an autoimmune disease
  • Spirometry results
    FEV1/FVC = normal/slightly higher
    FVC = lower
29
Q

Obstructive Diseases

A
  • Mechanism
    1. Measure on outflow with FVC.
    2. FVC is normal; although airways are tighter, they can get a normal amount of air in and out, just takes longer.
    3. FEV1 is lower because they can’t get air out quick enough.
  • Causes
    • COPD which includes emphysema and chronic bronchitis
    • asthma
    • bronchiectasis
    • CF
  • Spirometry results
    FEV1/FVC = normal/lower
    Confirmed if FEV1 = <80% of the predicted value and FEV1/FVC = <70%
30
Q

What 2 conditions can lead to COPD?

A

Bronchitis and emphysema

31
Q

Explain the pathophysiology of bronchitis.

A
  • could be caused by infection
  • thickened airway walls
  • narrower lumen
  • overproduction of mucus due to overactivity/increased number of goblet cells in response to inflammation and irritants
  • symptoms could include phlegm cough (had for at least 3 months for 2 consecutive years)
32
Q

Explain the pathophysiology of emphysema.

A
  • interconnections between alveoli gets broken down and results in increased sacs results in smaller SA:V ratio, resulting in less efficient GE
  • no elastic recoil that helps to push air out
  • narrowing of airways
33
Q

Mr. Craven X-ray vs. Normal

A

Smaller heart

Smaller + flattening of diaphragm

Gastric bubble

Hyper-expansion (more air in spaces than you would expect)

34
Q

What are the signs of hyperinflation?

A
  • more than 7 anterior ribs visible at the mid-clavicular line (although this is not particularly sensitive)
  • flattening of the diaphragm (may be a more sensitive sign)
  • heart may appear small and narrow, sometimes with air visible below the inferior border (floating heart sign)
  • emphysema on CXR can be seen as hyperinflation, there may also be a bullae present
35
Q

What is bullae?

A

Air-filled spaces with thin wall, bordered only by remnants of alveolar septae or pleura.

Often caused by emphysema.

36
Q

What does bullae look like on a CXR?

A

Areas of low density → Black = lots of air

May be outlined by resembling bubbles.

37
Q

What factors can help in the treatment of COPD?

A

stop smoking

eating well and maintaining a healthy weight

keeping well in the cold

take prescribed medications

control breathing

keeping active

looking after mental health

pulmonary rehabilitation (PR); exercise and education programme to help people with COPD cope with getting out of breath

38
Q

Advice for patients with COPD?

A
  • Smoking cessationNRTStop smoking medication
  • NutritionMaintain healthy weightObesity; heart and lungs work harder, can add restrictive disorder.More fibreLimit simple carbohydrates
  • Keeping warmAvoid catching coldGP may give care pack; ABs and steroids to take if they think they’re becoming unwell.
39
Q

Short-acting bronchodilator therapy

A
  • Mechanism
    • Beta-2 agonists; SNS dilates airways through beta adrenergic receptors
    • Muscarinic antagonists; antagonistically works against paraNS that keeps airways constricted
    • both come in long acting and short acting forms
  • Examples
    • short acting beta agonists (SABA) → Salbutamol (Ventolin)
    • short acting muscarinic antagonists (SAMA) → Ipratropium bromide (Atrovent)
40
Q

Long-acting bronchodilator therapy

A
  • Mechanism
    • Beta-2 agonists; SNS dilates airways through beta adrenergic receptors
    • Muscarinic antagonists; antagonistically works against paraNS that keeps airways constricted
    • both come in long acting and short acting forms
  • Examples
    • Long acting beta agonists (LABA) →Formoterol, Salmeterol (Serevent)
    • Long acting muscarinic antagonists (LAMA) → Tiotropium (Spiriva), Glycopyrronium
41
Q

Inhaled corticosteroids (ICS)

A
  • Mechanism
    • Anti-inflammatory for airways
    • reduces the risk of flare-ups or exacerbations
    • useful for people whose condition is an overlap of asthma and COPD
    • numerous different inhaler devices exist
    • numerous drug combinations exist within a single inhaler
  • ExamplesAlone - not licensed in COPD → Beciomestasone, Fluticasone (Flixotide)In combination e.g. with a LABA → Fluticasone + Vilaterol (together = Revlar)
42
Q

Why are smoking cessation treatments good?

A

Reduces the risk of developing or worsening of smoking-related illnesses benefits begin as soon as a person stops smoking.

43
Q

What are the symptoms associated with smoking cessation treatments?

A

Nicotine cravings, irritability, depression, restlessness, poor concentration, light-headedness, sleep disturbances and increased appetite.

44
Q

What type of non-drug treatment offers the best chance of lasting success?

A

Stopping in one step (‘abrupt quitting’) offers the best chance of lasting success and that a combination of drug treatment and behavioural support is likely to be the most effective approach.
Abrupt quitting- When a smoker makes a commitment to stop smoking on or before a particular date (the quit date), rather than by gradually reducing their smoking.

45
Q

What should choice of drug treatment for smoking cessation be based of?

A

Smoker’s age, likely adherence, preferences, whether they’re pregnant or breastfeeding, medical conditions, and previous experience of smoking-cessation aids, as well as contra-indications and side-effects of each preparation.

46
Q

What are the most-effective drug treatment options for smoking cessation?

A

Varenicline, or a combination of long-acting NRT (transdermal patch) and short-acting NRT (lozenges, gum, sublingual tablets, inhalator, nasal spray and oral spray), are the most effective treatment options and thus the preferred choices.

What is used if the combination isn’t appropriate?
Bupropion hydrochloride or single therapy NRT should be considered instead.

47
Q

Should any combination of NRT, varenicline and bupropion hydrochloride be prescribed together?

A

No

48
Q

Drug treatment type

A
  • NRT
  • Varenicline (Champix)
  • Bupropion hydrochloride (Zyban)
    Check notion for more
49
Q

What are e-cigarettes and why are they better than cigarettes?

A

Electronic device that delivers vapour composed of nicotine without the toxins found in tobacco smoke e.g. tar or CO.

Evidence suggests that e-cigarettes are substantially less harmful to health than tobacco smoking, but long-term effects are still largely unknown.

50
Q

Can e-cigarettes be prescribed?

A

Can’t be prescribed or supplied by smoking cessation services (you have to buy them).

51
Q

Who can’t buy e-cigarettes?

A

Under 18s

52
Q

In terms of smoking, what should pregnant women be advised to do and why?

A

Stop smoking completely, and be informed about the risks to the unborn child of smoking during pregnancy, and the harmful effects of exposure to second-hand smoke for both mother and baby.

All pregnant females who smoke or have stopped smoking in the last 2 weeks should be referred to their local NHS Stop Smoking Services, and ongoing support should be offered during and following pregnancy.

(Smoking cessation should also be encouraged for all members of the household)

Pregnant females who smoke should be advised to contact the NHS Pregnancy Smoking Helpline for further information.

53
Q

When should NRT be used in pregnant females?

A

NRT should only be used in pregnant females if non-drug treatment options have failed.

Clinical judgement should be used when deciding whether to prescribe NRT following a discussion about its risks and benefits. Subsequent prescriptions should only be given to pregnant females who have demonstrated they are still not smoking.

54
Q

How do concomitant drugs work?

A

Polycyclic aromatic HC found in tobacco smoke increase the metabolism of some drugs by inducing hepatic enzymes, often requiring an increase in dose.

55
Q

What are the types of inhalers?

A

Metered Dose Inhalers (with or W/O spacer)

Dry powder Inhalers (Single/multiple dose)

Nebulisers (Jet/Ultrasonic/Mesh)

56
Q

What should you ask the patient to do in order to assess which inhaler to prescribe?

A

Ask the patient to try both inhalation manoeuvres:

  1. Quick and deep - can the patient take a quick deep breath in within 2-3 seconds
  2. Slow and steady - can the patient take a slow, steady breath in over 4-5 seconds.

Inhaler prescription options:
- CAN perform a quick and deep only
DPI
- CAN perform BOTH
DPI, pMDI or SMI
- CAN perform slow and steady only
pMDI or SMI

57
Q

What can you do if you’re still unsure after observing the patient?

A

Consider the use of devices to assess inspiratory health such as:

AIM machine, device training attachments, flo-tone trainer, in-check DIAL inspiratory flow meter.

58
Q

When selecting a specific inhaler device, and at every patient review, what are the 7 steps for correct inhaler technique?

A

Preparation

Priming

Exhaling

Mouth

Inhalation

Breath holding

Closing and repeating

59
Q

What should you do if after review of inhaler technique, patient and healthcare professional agree that chosen device is inappropriate?

A

Consider alternative device and redo those 7 steps.

60
Q

What are spacers?

A

Large, empty devices (or tubes) that are usually made out of plastic. Help get the best from asthma medicine if you use a metered dose inhaler (MDI).

MDIs:
- deliver a dose of medicine in a fine spray (aerosol) form
- can be difficult to use them correctly as you need to breathe in at exactly the same time as you press down on your inhaler to release the medicine
- also need to breathe in very slowly and deeply

61
Q

How can spacers help manage airway disease better?

A
  • make it easier to get the right amount of medicine
  • using a spacer helps the medicine get straight to your lung
  • inhaler is fixed on one end of the spacer and the mouthpiece at the other
  • when you press on your inhaler, the medicine collects in the chamber of the spacer, so you can breathe it in without needing to get the timing and speed exactly right
  • an asthma inhaler with a spacer can also help if you’re having an asthma attack
62
Q

How does a spacer help you use less medicine?

A
  • a spacer slows the medicine down as it comes out of the inhaler, so more gets taken down into the lungs
  • makes the medicine more efficient, so may need to use less
63
Q

Explain how spacers reduce the risk of side effects.

A
  • spacers reduce the small risk of side effects if you’re taking preventer (steroid) medicine
  • more of the medicine gets into your lungs, less medicine is absorbed into the rest of your body, lowering the risk of side effects
  • this also reduces the risk of voice changes and oral thrush: a fungal infection that can be a side effect of asthma inhalers, particularly in children
64
Q

Why is it good to keep your spacer clean?

A
  • keeping the spacer clean will help get the full benefits of the asthma medicines
  • follow the manufacturer’s instructions
  • if it’s a new spacer, clean it before you use it for the first time, then once a month afterwards
65
Q

What are the 2 breathing techniques you can use with your spacer?

A

1) the ‘tidal or multiple breathing’ technique
2) the ‘single breath and hold’ technique