6 - Bladder Dysfunction Flashcards
Central Pathways of Bladder. 4 marks ππ
1- Frontal Lobe Cortical Micturition Center (CMC)
Inhibits parasympathetic sacral micturition center
Controlling external urethral sphincter
Result in social inhibition and control of micturition
2- Pontine micturition center (PMC)
Coordinates bladder contraction and sphincter relaxation
3- Sacral Micturition Center (Pelvic and pudendal nuclei)
Micturition reflex mediated by parasympathetic sacral pelvic n. (S2βS4)
4- Motor cortex to pudendal nucleus
Voluntary control of external urethral sphincter
Cuccurollo 4th Edition Chapter 7 SCI pg566
Peripheral Efferent Pathways of Bladder. 3 marks ππ
1- SYMPATHETIC
Nerve
Hypogastric nerves (T11βL2)
Receptor & Location
Body of the bladder (Beta-2 adrenergic receptors)
Base of the bladder and prostatic urethra (Alpha-1 adrenergic receptors)
Neurotrasnmitter
Norepinephrine
Function
Beta adrenergic receptors within the body of the bladder causes smooth muscle relaxation (compliance)
Alpha adrenergic receptors within the base of the bladder/prostatic urethra causes smooth muscle contraction (increase outlet resistance)
Goal
Urine storage
2- PARASYMPATHETIC
Nerve
Pelvic nerves (S2βS4)
Receptors & Location
Bladder wall, trigone, bladder neck (Cholinergic muscarinic receptors)
Neurotrasmitter
Acetylcholine (Ach)
Function
Bladder contraction and emptying
3- SOMATIC
Nerve
Pudendal nerve (S2-S4)
Receptor
Cholinergic nicotenic receptors
Neurotrasmitter
Acetylcholine (Ach)
Function
Innervate striated muscle of external urethral sphincter.
Function
Voluntary contraction for preventing leakage or emptying
Cuccurollo 4th Edition Chapter 7 SCI pg566
Afferent Pathways of bladder. ππ
1- Pelvic nerve (parasympathetic)
Detrusor muscle stretch receptors
Bladder wall tension
Bladder mucosal nociception (pain, irretation)
2- Pudendal nerves
External anal and urethral sphincters, perineum, genitalia
Urethral mucosal sensation (pain, tempreture, passage of urine)
Cuccurollo 4th Edition Chapter 7 SCI pg568
Braddom 5th Edition Chapter 20 Bladder
Compare Urethral Sphincters (Nerve - Receptor - Type of Muscle - Function)ππ
INTERNAL SPHINCTER
- T11βL2 hypogastric nerve (sympathetic)
- Alpha-adrenergic receptors (Norepinephrine)
- Smooth muscle, involuntary
- Contracts sphincter for storage
- Thatβs why we use alpha block, omnic!
EXTERNAL SPHINCTER
- Pudendal nerve (S2βS4) (parasympathetic)
- Nicotinic receptor (ACh)
- Skeletal muscle, voluntary
- Voluntary preventing leakage or facilitate emptying
Cuccurollo 4th Edition Chapter 7 SCI pg568
You are meeting a patient with bladder dysfcuntion, explain to his how does the bladder work.
How does the bladder work when the spinal cord is intact? 3 marks. ππ (OSCE)
1- Urine Production
Urine produced by the kidneys passes through the ureters to fill the bladder. When the bladder is not full, the bladder wall muscle is relaxed. The bladder sphincter muscles are tightened so urine does not leak out.
2- Urine Storing
When there is enough urine to stretch the bladder walls, a nerve signal is sent up the spinal cord to tell the brain that the bladder is full. Because the brain controls the external sphincter muscle, urine can be held until an appropriate time to empty.
3- Urine Emptying
When the bladder is to be emptied, signals are sent from the brain down the spinal cord to cause the coordinated squeezing of the bladder wall muscle and relaxation of the bladder sphincter muscles to allow urine to pass through the urethra and out of the body.
Normal range of bladder volume and detrusor pressure. ππ (OSCE)
Bladder Sensation
Starts around 200ml up to 500ml where patient starts to feel urgency
Bladder Capacity
( Age + 1 ) x 30mL for < 12 years
500-700ml for 12+ years
Voiding Volume
Each void less than 500
Residual Volum
Less than 100
Detrusor pressure
5-10 mmH2O
> 40 mmH2O may harm the kidney
List the type of bladder dysfcuntion in each lesion site ππ
- Rostral to (above) pons
- Between pons and sacral spinal cord
- Sacral spinal cord
- Cauda equina or peripheral nerves.
Rostral to (above) pons
Detrusor hyperreflexia with coordinated sphincters (UMN Bladder)
Between pons and sacral spinal cord
Detrusor hyperreflexia with sphincter dyssynergia (DSD)
Sacral spinal cord
Detrusor and sphincter areflexia (normal detrusor function with areflexic sphincter).
Cauda equina or peripheral nerves
Detrusor and sphincter areflexia.
UMN bladder. Causes, Lesion site, Presentation & Treatment. ππ
Causes
- Parkinson
- Brain Tumor
- Traumatic Brain Injury
- Subacute CVA (detrusor hyperreflexia)
- Multiple sclerosis
- Transverse myelitis
- Degeneration (cervical spondylosis).
- Thoracolumbar Trauma (SCI)
- Vascular (AVM) (Non-traumatic SCI)
Sacral Reflex
- Lack of inhibition of sacral micturition center
- Result in detrusor overactivity - hyperactive bladder
Presentation
- Reduced or complete loss of bladder sensation
- Failure to store: Small & Overactive, Random emptying (accidents)
- Failure to empty: Spastic bladder neck and sphincter
Treatment
- Behavioral/Life Style
- Timed void
- Scheduled fluid intak
- Routine water intake to minimize urgency, leaks or accidents
- Minimize fluid and caffeinated beverage past 6pm
- Collecting Devices
- Diaper (eldarly or dementia)
- Indwelling catheters (no care giver or poor hand skills)
- External condom catheter (low outlet obstruction)
- Clean intermittent catheterization (good hand skills and adherence)
- Suprapubic cacatheterizationher (problems with previous methods)
- Pharmacological
- Anticholinergics (anti-detrusor) : Oxybutinin, Solifenacin (Vesicare)
- Alpha-adrenergic blockers (anti-sphincter): Tamsulosin (Omnic)
- Botulinum toxin (Botox) injections to relax the bladder muscles
- Intrathecal baclofen (SCI patient with LL spasticity)
- Surgical
- Augmentation
- Diversion (Urostomy)
- Denervation
- Bladder neck incision
- Sphincterotomy incision
- Sphincterotomy
- Prostate resection
- Pudendal neurectomy
Cuccurollo 4th Edition Chapter 7 SCI pg572 Table 7-9
Braddom 5th Edition Chapter 20 pg436 Table 20-4
DeLisa 5th Edition Chapter 7 SCI pg1358 Table 51.3
LMN bladder. 4 Causes (MOCK), Lesion site, Presentation & Treatment. ππ
Causes
- Spinal shock: Reflex arc not functioning
- Acute CVA (detrusor areflexia)
- Conus medullaris syndrome
- Cauda equina syndrome
- Syringomyelia
- Herniated lumbar disk.
- Lumbar spinal stenosis.
- Amyotrophic lateral sclerosis
- Burst Fracture L1
Sacral Reflex
- Absent
Presentation
- Reduced or complete loss of bladder sensation
- Overflow incontinence
- Failure to empty: Large, areflexic, flaccid bladder, urine retention
Treatment
- Behavioral/Lifestyle
- Timed voids
- Pelvic floor exercises (limit stress incontinence)
- Reflex voiding, Valsalva and CredΓ© maneuvers (risk for β reflux )
- Scheduled fluid intake
- Routine water intake to minimize urgency, leaks or accidents
- Minimize fluid and caffeinated beverage past 6pm
- Collecting Devices
- Diaper (eldarly or dementia)
- Indwelling catheters (no care giver or poor hand skills)
- External condom catheter (low outlet obstruction)
- Clean intermittent catheterization (good hand skills and adherence)
- Suprapubic cacatheterizationher (problems with previous methods)
- Pharmacological
- Bethanechol: Stimulate cholinergic receptors (rarely used)
- Ξ±-Agonists
- Surgical
- Artificial sphincter
Cuccurollo 4th Edition Chapter 7 SCI pg572 Table 7-9
Braddom 5th Edition Chapter 20 pg436 Table 20-4
LMN bladder. 4 Causes (MOCK), Lesion site, Presentation & Treatment. ππ
Causes
- Spinal shock: Reflex arc not functioning
- Acute CVA (detrusor areflexia)
- Conus medullaris syndrome
- Cauda equina syndrome
- Syringomyelia
- Herniated lumbar disk.
- Lumbar spinal stenosis.
- Amyotrophic lateral sclerosis
- Burst Fracture L1
Sacral Reflex
- Absent
Presentation
- Reduced or complete loss of bladder sensation
- Overflow incontinence
- Failure to empty: Large, areflexic, flaccid bladder, urine retention
Treatment
- Behavioral/Lifestyle
- Timed voids
- Pelvic floor exercises (limit stress incontinence)
- Reflex voiding, Valsalva and CredΓ© maneuvers (risk for β reflux )
- Scheduled fluid intake
- Routine water intake to minimize urgency, leaks or accidents
- Minimize fluid and caffeinated beverage past 6pm
- Collecting Devices
- Diaper (eldarly or dementia)
- Indwelling catheters (no care giver or poor hand skills)
- External condom catheter (low outlet obstruction)
- Clean intermittent catheterization (good hand skills and adherence)
- Suprapubic cacatheterizationher (problems with previous methods)
- Pharmacological
- Bethanechol: Stimulate cholinergic receptors (rarely used)
- Ξ±-Agonists
- Surgical
- Artificial sphincter
Cuccurollo 4th Edition Chapter 7 SCI pg572 Table 7-9
Braddom 5th Edition Chapter 20 pg436 Table 20-4
In detrusor areflexia (LMN bladder), why do some patients have difficulty emptying?
Internal sphincter tone is usually flaccid with LMN lesion, but may be intact due to sympathetic innervation, causing difficulty with complete emptying.
Ref: http://www.scireproject.com/case-studies/case-6-mr-r-b/neurogenic-bladder
List 8 reversible factors for incontinence ππ
ASIA A C8 increasing incontinence. 4 causes.
List 4 urodynamic and functional causes of incontinence in neurogenic bladder dysfunction
Caused by the bladder
- Detrusor overactivity
- Decreased capacity
- Low bladder wall compliance
- Normal (cognitive/mobility issue)
Caused by the outlet
- Incompetent sphincter
DeLisa 5th Edition Chapter 7 SCI pg1351 Table 51.2
DIAPPERS
- Delirium
- Infection
- Atrophic vaginitis, urethritis
- Pharmaceuticals
- Psychological (Depression)
- Endocrine (Diabetes, Sodium abrnomalities)
- Reduced mobility
- Stool impaction
DeLisa 5th Edition Chapter 51 Neurogenic Bladder & Bowel pg1353
List 4 classes of treatment for enhancing bladder volumes in hyper-reflexic bladder in SCI.
Collecting Devices
- Intermittent or indwelling catheter
Pharma
- Oral Anticholinergics (Oxybutynin, Solifenacin) β First line therapy
- Alpha-Adrenergic Blockers
- Botulinum toxin A (BTX-A)
- Intravesical instillations of oxybutinin
- Intrathecal baclofen/clonidine
Surgical
- Surgical Augmentation
- Urinary Diversion
https://scireproject.com/wp-content/uploads/SCIRE_Bladder_V7.pdf
List 4 urodynamic and functional causes of retention in neurogenic bladder dysfunction
Caused by the bladder
- Detrusor areflexia
- Large capacity/high compliance
- Normal (cognitive/mobility issue)
Caused by the outlet
- High voiding pressure with low flow rate
- Internal sphincter dyssynergia
- External sphincter dyssynergia
- Overactive sphincter mechanism (i.e., sphincter or pseudosphincter dyssynergia)
DeLisa 5th Edition Chapter 7 SCI pg1351 Table 51.2
Which drug will best lower urethral resistance?
Alpha-adrenergic antagonists (Omnic 0.4mg OD)
What is Detrusor sphincter dyssynergia (DSD)? When does it happen? π
Successful micturition reflex
- Bladder sphincter must relax just before the onset of a bladder contraction
- Goal is unobstructed voiding
- Itβs coordinated via PMC
Pontine micturition center (PMC)
- Coordination of bladder contraction and sphincter activity
- Disruptions in pathways between the PMC and the sacral outflow to the bladder can lead to detrusor sphincter dyssynergia, a leading cause of obstruction in individuals with suprasacral spinal cord injury (SCI).
Detrusor sphincter dyssynergia (DSD)
- Involuntary urinary sphincter contraction
- Increased activity of detrusor muscle contraction in the same time.
Neurological injury
- Between the sacral micturition center (S2βS4) and pontine micturition centers
Cuccurollo 4th Edition Chapter 7 SCI pg574
Braddom 5th Edition Chapter 20 Bladder pg429
What to monitor for patients with neurogenic bladder?
π‘ Blood - Imaging - Special Tests
- Blood urea nitrogen (BUN) and creatinine.
- Renal ultrasound (at least yearly) to identify reflux or hydronephrosis
- Measurement of a postvoid residual urine volume (PVR)
- Signs and symptoms of AD during voiding.
- Monitored for UTIs
Why SCI patients are at higher risk of developing CKD? 4 marks
π‘ Stone β Obstruct β Reflux β Bacteria
- Nephrolithiasis (stones)
- Obstructive nephropathy (sphincter)
- Reflux nephropathy (hypertrophied bladder wall)
- Chronic pyelonephritis (infections)
List 4 urinary complications seen in SCI
- Bacteriuria & UTIs
- Hypercalciuria and Stones
- Vesicoureteral reflux (VUR)
- Hydronephrosis
- Renal deterioration
- Autonomic Dysreflexia
Cuccurollo 4th Edition Chapter 7 SCI pg576
Mention 4 UTI sign and symptoms in SCI patient
π‘ The symptoms of urinary tract infections are not always easy to recognize.
- More frequent or severe muscle spasms (increased spasticity)
- Autonomic dysreflexia (in people with injuries above T6)
- Fever, chills
- Malasia
- Cloudy urine
- Hematuria
- Bad-smelling urine
- Increased frequency
- Urinary incontinence
- Pain or burning feeling while urinating (if sensation is present)
- Pain in the abdomen or back (if sensation is present)
What test can be employed to differentiate prostatitis from pyelonephritis?
Elevated PSA (prostate-specific antigen) is seen in prostatitis