6. Alternative intervention study designs Flashcards
(e.g., cross-over design, factorial design, Latin square design, prerandomization design (Zelen design), sequential analysis approaches, N of 1 trial designs, single case methodology designs, group-randomized trial design).
1
Q
What is counterbalancing in n-of-trials?
A
When progressive deterioration or improvement is expected > outcomes of the intervention in the latter
position will be worse or better
A counter-balanced design could be used (e.g. ABBA or BAAB). Neither treatment suffers worse fate
or benefits, solely based on the ordening within a treatment block.
2
Q
What is the difference in measurements during a crossover trial?
A
- More often
- Depend on the stability of the outcome measurement during each phase
