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Neuro- Roos P2 > 5] SCI Part 1 > Flashcards

5] SCI Part 1 Flashcards

1
Q

Traumatic causes of SCI

A 
MVA
Falls
Violence
Other
Sports
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2
Q

Average age of spinal cord injured person is

A

41

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3
Q

56% of injuries occur ?

A

Between ages of 16-30 (very young)

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4
Q

Cause of death with SCI

A

Pneumonia and septicemia

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5
Q

41%

A

Incomplete tetra

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6
Q

Around 22%

A

Complete para

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7
Q

Around 21%

A

Incomplete para

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8
Q

Around 16%

A

Complete tetra

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9
Q

Ethnicity for SCI

A

Caucasian

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10
Q

1 year post SCI, how many are employed

A

12%

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11
Q

20 years post SCI, how many are employed?

A

35%

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12
Q

Primary patho of SCI

A

Mechanical damage due to deformation of spine

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13
Q

Secondary patho of SCI

A

Cascade of biochemical and cellular processes

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14
Q

2 corticosteroids for medical management of acute SCI

A

Methylprednisone (naloxone)

Tirilazad mesylate

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15
Q

In animal studies: (Geisler et al, 1991)
 Promotes growth of nerve cells
 Regeneration of damaged nervous tissues

A

GM-1 ganglioside

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16
Q

Methylprednisolone prevents (3)?

A

Lipid peroxidation
Post-traumatic ischemia
Destruction of neuronal and microvascular membranes

17
Q

Lipid peroxidation results in

A

Preservation of: spinal blood flow, metabolism, Na and K homeostasis

18
Q

Reduction of lipid peroxidation

A

Damage from high levels of extracellular calcium, excitotoxicity, protease-mediated to neuro-filament proteins

19
Q

Available medical evidence does not
support a significant clinical benefit from
the administration of THIS in
the treatment of patients after acute SCI

A

GM-1 ganglioside

20
Q

For neuropathic pain

A

Pregablin (lyrica)

21
Q

Mechanism of action for pregabalin (lyrica)

A

◦ Works similar to gabapentin

◦ reduces the synaptic release of several neurotransmitters

22
Q

MOA for pregabalin is that it reduced the synaptic release of several neurotransmitters by: (2)

A

 binding to alpha2-delta subunits

 Reduce neuronal excitability and seizures

23
Q

Medical complications of SCI

A

Autonomic dysfunction

Autonomic dysreflexia

24
Q

Autonomic dysfunction is a ?

A

Medical emergency

25
Q

sensory loss, motor
paralysis, loss of bowel and
bladder control

A

Autonomic dysfunction

26
Q 
Increased BP
Bradycardia
 Nasal congestion   
 Pounding headache
 Anxiety
 Flushing
 Profuse sweating
A

Autonomic dysreflexia (T6 and above)

27
Q

Cause of autnomic dysreflexia

A

Anything that can be perceived as a noxious stimulation

28
Q

Treatment of autonomic dysreflexia

A

Immediately sit person upright

Fix problem

29
Q

Medical complications of SCI

A 
Skin breakdown
DVT
UTI
Osteoporosis
GI issues 
HO
Pain
Spasticity
30
Q

Factors predisposing individuals to WHAT?
 peripheral vasodilation
 absent/reduced LE muscle function
 immobility
 hypercoagulability
 trauma
 sepsis

A

DVT

31
Q 
◦ Urinary Retension
◦ Reflux
◦ Kidney and bladder stones
◦ Kidney failure
◦ Septicemia
A

UTI complications

32
Q

usually stabilizes 16 months after injury with 2/3 of original bone mass

A

Osteoporosis

33
Q

Rapid loss in 1st 6 months

A

Osteoporosis

34
Q 
Bleeds (steroids)
paralytic ileus
◦ gastric dilation - affects respiration
◦ fecal impaction
◦ bowel obstruction
A

GI issues

35
Q

◦ Swelling, pain & local increase in temperature
◦ bone formation at a joint
 Hips & knees,
 Shoulders & elbows (tetraplegia only)

A

HO

36
Q

Chronic pain, spinal cord/brain changes in makeup

A

Nerve root pain

37
Q

Broken, bruised

A

Traumatic pain

38
Q

Young ppl, sing arms like legs, everything is flexed forward and puts shoulders at disadvantage, impingement

A

MSK pain

39
Q

Initial period around 2 months of areflexia

A

Spasticity

Neuro- Roos P2 (4 decks)

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