5 Hematologic Diseases Flashcards
- responsible for recognition and processing of foreign antigens (viruses, fungi, bacteria)
- protective function
lymphoid tissue
During response to antigenic challenges, how do lymph cells respond?
lymph cells proliferate –> results in enlargement of the lymphoid tissue (hyperplasia)
Sites of lymphoid tissue:
- lymph nodes
- lymphoid tissue of Waldeyer’s ring
- aggregates of lymphoid tissue normally scattered throughout the oral cavity: oropharynx, soft palate, lateral tongue, floor of mouth
- head and neck region
Where can lymphoid hyperplasia occur?
any site of lymphoid tissue
Intraoral indications of lymphoid hyperplasia:
- description
- size
- color
- locations (3)
- discrete, nontender, submucosa swellings
- < 1 cm in diameter
- normal, dark pink, creamy yellow-orange hue
- posterior lateral tongue, floor of mouth, wall of pharynx
reasons for enlarged lymph nodes: acute vs chronic infection
Acute- enlarged, tender, relatively soft, freely moveable
Chronic- enlarged, rubbery firm, nontender, freely movable, history of a previous inflammatory illness, should be a lack of progressive enlargement
differentials (2) for multiple persistently enlarged nontender lymph nodes
lymphoma
HIV infection
peak of tonsillar size
peaks early during the second decade of life (usually more prominent in younger people)
symmetric vs asymmetric LARGE tonsils
As long as the large tonsils are symmetrical and asymptomatic, we do nothing!
Tonsillar asymmetry is a potentially serious sign that should be evaluated further to rule out the presence of a malignancy.
decrease in the volume of RBCs (hematocrit) or in the concentration of hemoglobin
anemia
often a sign of underlying disease
anemia
Symptoms related to decreased O2 carry capacity due to anemia:
- tired
- headache
- lightheaded
- pallor of mucosa
genetic disorder of hemoglobin synthesis–> hemoglobinopathy
sickle cell anemia
genetic cause of sickle cell anemia
thymine substituted for adenine in DNA –> altered codon results in valine instead of glutamic acid in the beta-globin chain of hemoglobin
- deoxygenated hemoglobin molecule is prone to molecular aggregation and polymerization
- RBCs undergo deformation and take on a rigid sickle shape
sickle cell anemia
sickle cell trait vs disease
Sickle cell trait = one allele is affected (45-50% of hemoglobin is normal, no significant clinical manifestations)
Sickle cell disease = both alleles affected (1:350-400 black people in the US)
1:350-400 black people in the US
sickle cell disease
tissue/organ affected by sickle cell anemia
any tissue or organ
Clinical findings of sickle cell anemia? How many patients have severe involvement?
- highly variable clinical findings
- 1/3 of patients have severe involvement
patients with sickle cell anemia are more prone to these infections
S. pneumoniae (thought that susceptibility develops following splenic destruction from repeated infarctions)
delayed growth and development from sickle cell anemia
impaired kidney function and ocular abnormalities due to repeated occlusive episodes in small vessels
when the sickling of erythrocytes becomes severe
sickle cell crisis
Causes (5) of sickle cell crisis:
- most have unknown cause
- hypoxia
- infection
- hypothermia
- dehydration
A sickle cell crisis causes extreme pain from ______ and ______ of affected tissue. What are the most common affected locations?
ischemia and infarction / long bones, lungs, and abdomen most affected
How long do episodes of sickle cell crisis last?
3-10 days
tx for sickle cell crisis
- supportive care, fluids, rest, analgesics
- avoid exposure to cold, dehydration, and strenuous exercise to avoid sickle cell crisis
oral manifestation: hair on end appearance of skull bones
sickle cell anemia
oral manifestation: reduced trabecular pattern of the mandible due to increased hematopoiesis in marrow
sickle cell anemia
oral manifestation: asymptomatic pulpal necrosis
sickle cell anemia
oral manifestation: increased prevalence of osteomyelitis
sickle cell anemia
tx for sickle cell anemia
- continuous prophylactic penicillin therapy until age 5 to prevent S. pneumoniae infection
- pneumococcal vaccination
- hydroxyurea –> increases fetal form of hemoglobin
- avoid exposure to cold, dehydration and strenuous exercise to avoid sickle cell crisis
- genetic counseling
tx: continuous prophylactic penicillin therapu until age 5 to prevent S. pneumoniae infection
sickle cell anemia
tx: pneumococcal vaccination
sickle cell anemia
tx: hydroxyurea –> increases fetal form of hemoglobin
sickle cell anemia
tx: genetic counseling
sickle cell anemia
disorders of hemoglobin synthesis due to reduced synthesis of either the alpha-globin or beta-globin chains of the hemoglobin molecule
thalassemias