5. Drug action, Drug study and Evidence-based nursing

Question 1

What are the principles of Drug Action?

Answer 1

• Drugs do not create new response, but it alters existing physiologic activity.
  -Drugs interact with the body in several
  different ways. It forms chemical bonds with
  receptors.
• Most drugs have several different atoms
  within each molecule that interlock into
  various receptors.
• Drugs interact with receptor to stimulate a
  response are known as AGONISTS.
• Once drug is administered, a drug goes
  through 4 phases: Absorption, Distribution,
  Metabolism and Excretion

Question 2

Facts about the Lipid solubility: blood brain barrier?

Answer 2

• Found within the walls of capillaries and
  vessels.
• Protective system which keeps many things
  (foreign invaders, poison) away from the CNS

Question 3

Facts about the Placenta Breastmilk?

Answer 3

• Many drugs readily pass through the placenta
  and affect the developing fetus.
• It is NOT the best to administer drug to
  pregnant women due to possible risk to fetus.
• Given ONLY when the BENEFIT CLEARLY
  OUTWEIGHS THE RISK.

Question 4

What are the factors affecting the body’s response to drug?

Answer 4

Weight, Age, Sex, Physiologic factors, Pathologic Factors, Genetic Factors, Immunologic Factors, Psychologic Factors, Environmental Factors, Tolerance, Cumulation effects.

Question 5

What are the parts of a drug study?

Answer 5

1. Drug Details
2. Indication
3. Contraindications
4. Mechanism of actions
5. Side effects/ Adverse effects
6. Nursing Responsibilities- assess, plan,
   intervene, evaluate.