5/9 HAC

Question 1

What syndrome is an acute, febrile, mucocutaneous disorder following use of sulfonamides?

Answer 1

Stevens Johnson syndrome

Question 2

What drugs cause Stevens Johnson Syndrome?

Answer 2

Sulfonamides
NSAIDs
Anticonvulsants
Allopurinol

Question 3

What infectious commonly causes Stevens Johnson syndrome?

Answer 3

Mycoplasma pneumoniae

Question 4

What are some common clinical features of Stevens Johnson Syndrome?

Answer 4

Coalescing erythematous macules, bullae, desquamation, mucositis

Fever, tachycardia, hypOtension, AMS, conjunctivitis, seizures, coma

Question 5

Some anti-epileptic drugs (like phenytoin, primidone, phenobarbital) can cause anemia by what pathophysiology?

Answer 5

Impaired absorption of folic acid. Needs supplementation.

Question 6

Aside from anti-epileptics, what other drugs can cause folic acid deficiency?

Answer 6

Trimethoprim

Methotrexate (anti-folate effects can be reversed with leucovorin, i.e. folinic acid)

Question 7

Deficiency of what mineral can cause alopecia, abnormal taste, impaired wound healing, and bullous, pustular lesions around the mouth?

Answer 7

Zinc

Question 8

What is the most important feature of selenium deficiency?

Answer 8

Cardiomyopathy

Question 9

What drugs shift potassium intracellularly?

Answer 9

Insulin, glucose, sodium bicarb, beta-2-agonists

Question 10

What is the main lab difference between Familial Hypocalciuric Hypercalcemia and Primary Hyperparathyroidism?

Answer 10

FHH has very low urinary calcium levels (

Question 11

What are the extraintestinal manifestations of Whipple’s disease?

Answer 11

Migratory polyarthropathy, chronic cough, myocardial or valvular involvement (leading to CHF or valvular regurge)

PAS positive lamina propria

Question 12

What are the main infectious causes of Primary Adrenal Insufficiency?

Answer 12

Tuberculosis
Fungal infections
CMV infections

Question 13

What is the most common treatment for osteoporosis?

Answer 13

Bisphosphonates