4C- Miotic Slindles And Cytokineses Flashcards
What are the stages of the cell cycle?
Interphase, Mitosis (Prophase, Metaphase, Anaphase, Telophase), Cytokinesis
The cell cycle consists of distinct phases that prepare the cell for division.
What is the function of the mitotic spindle?
Proper separation of chromosomes during mitosis
The mitotic spindle is crucial for ensuring that each daughter cell receives the correct number of chromosomes.
List the three types of microtubules that make up the mitotic spindle.
- Astral microtubules
- Kinetochore microtubules
- Interpolar microtubules
Each type of microtubule plays a specific role in chromosome movement and spindle stability.
What is the role of kinetochores in mitosis?
Attachment points for kinetochore microtubules on chromosomes
Kinetochores are essential for the movement of chromosomes during cell division.
What is the metaphase to anaphase transition checkpoint?
A checkpoint ensuring all kinetochores are attached to microtubules
This checkpoint prevents improper sorting of chromosomes during cell division.
Fill in the blank: The __________ is a region of a chromosome made up of proteins that allow anchoring of spindle microtubules.
kinetochore
Kinetochores play a crucial role in chromosome segregation.
True or False: The mitotic spindle begins to assemble in early metaphase.
False
The mitotic spindle begins to assemble in early prophase.
How does a cell know when to transition from metaphase to anaphase?
By ensuring all kinetochores are attached to microtubules
This sensing mechanism prevents errors in chromosome segregation.
What happens to sister chromatids during the transition from metaphase to anaphase?
The ‘glue’ holding sister chromatids together is removed, allowing them to be pulled apart
This separation is critical for proper chromosome distribution to daughter cells.
What are some drugs that target mitotic spindle assembly?
- Paclitaxel
- Docetaxel
These drugs are used in cancer therapy to disrupt spindle assembly and trigger cell cycle arrest.
What is the composition of the mitotic spindle?
A bipolar array made of microtubules, centrosomes, and associated motor proteins
The structural integrity of the spindle is vital for successful cell division.
What is the consequence of not all kinetochores being attached during mitosis?
Triggering of cell cycle arrest
This ensures that cells do not proceed with division until all chromosomes are properly aligned.
