4a. Sensory Systems Flashcards

1
Q

Taste Receptors

A

Characteristic distribution, regions are a mixture

Some overlap in response

Taste is a combination of the categories

Tongue also has mechanoreceptors and thermoreceptors

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2
Q

Taste Receptors: Categories

A
sour (foliate papillae)
sweet (fungiform papillae)
salty (fungiform papillae)
bitter (circumvallate papillae)
umami (fungiform papillae)
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3
Q

Taste Buds

A

Location of taste receptors

On tongue and other areas of mouth

Grouped in each of 3 types of papillae on tongue

1 bud = ~50 receptors

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4
Q

Taste Receptor: Hairs

A

Project into taste pore - pick up taste stimuli

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5
Q

Taste Transduction

A
  1. Dissolved substances initiate transduction (substance must be dissolved in saliva to come in contact with R)
  2. Depolarizing R potentials
  3. Some taste R have voltage gated Na channels, make AP and release ATP
  4. Other taste R have voltage gated Ca channels and release vesicles of ATP (ATP release as NT - depolarizes primary afferent nerve ending)
  5. Peripheral endings of CN VII, IX, X depolarize - fire faster
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6
Q

CN for Conscious Perception of Taste

A

CN VII Facial
CN IX Glossopharnygeal
CN X Vagus

Mostly 7 and 9

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7
Q

Taste Receptors: Modified Epithelial Cells

A

Depolarizing receptor potentials –> release of NT ATP –> AP in primary neuron

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8
Q

Salt

A

NaCL

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9
Q

Sour

A

H+ in citric acid

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10
Q

Sweet

A

Sugar (glucose)

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11
Q

Bitter

A

Alkaloids (quinine)

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12
Q

Umami

A

L glutamate

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13
Q

Taste Pathways

A
  1. taste receptors
  2. cranial nerves (1 neuron)
  3. brainstem - nucleus solitarius (2 neuron)
  4. Thalamus (3 neuron)
  5. Gustatory cortex - insula
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14
Q

Limbic System

A

Provides affective dimension of taste (emotional context)

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15
Q

Olfactory Receptors

A

primary afferent neurons - not a separate cell

In olfactory mucosa

Odorant molecules bind to receptors in cilia in mucus layer

CN I (olfactory) goes through cribriform plate to connect with olfactory receptor in olfactory mucosa

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16
Q

Olfactory Transduction

A
  1. Olfactory R binds odorant molecules –> activates G protein
  2. Increase in intracellular cAMP
  3. cAMP gated cation channels open - Ca2+ enters
  4. Depolarization - Cl- leaves through Ca2+ gated Cl- channels
  5. Depolarization travels to initial segment of olfactory nerve
  6. AP generated
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17
Q

Axons from olfactory receptors leave olfactory epithelium …

A

Travel ventrally to olfactory bulb - pass through cribriform plate

fractures of cribriform plate can sever olfactory neurons –> disorders

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18
Q

Odor Discrimination

A

Enabled by variations in receptor molecule

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19
Q

Olfactory Pathway

A
  1. olfactory receptors (1 neuron: CNI (olfactory))
  2. olfactory bulb: apical dendrites of mitral cells (2 neuron)
  3. primary olfactory cortex (piriform cortex)

Also project to amygdala, limbic system

NO RELAY IN THALAMUS

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20
Q

Outer Ear (anatomy, function)

A

Direct sound through ear canal to tympanic membrane

helix
auricle
auditory canal
earlobe

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21
Q

Middle Ear (function, anatomy)

A

Begins process of transmitting vibrations to inner ear

tympanic membrane?
ossicles (stapes, incus, malleus)

22
Q

Inner Ear (function, anatomy)

A

Transmits sound and balance information to brain

semicircular ducts?
vestibular nerve
cochlear nerve
cochlea
round window?
tympanic cavity?
tensor tympani muscle
auditory tube
23
Q

Cochlea

A

Contains receptor cells

Coils 2.5 around modiolus (bony pillar)

3 chambers:

  • scala tympani
  • scala media
  • scala vestibuli

2 fluids:

  • perilymph
  • endolymph

Hair cells sit in cochlear duct

24
Q

Perilymph

A

Fills scala vestibuli and scala tympani (continuous)

Similar composition to ECF

Movement –> bulges in cochlear duct –> activation of basilar membrane

25
Q

Endolymph

A

Fill scala media (cochlear duct)

Chemically similar to ICF (K+ rich)

Produced continuously via active pumping mechanism –> positive electrical potential inside ear (+80mV)

26
Q

Membranes of Cochlea

A
  • Reissner’s/vestibular membrane
  • Basilar membrane
  • Tectorial membrane
27
Q

Reissner’s Membrane

A

Roof of cochlear duct

28
Q

Basilar Membrane

A

Fibrous floor of cochlear duct

Supports organ of corti

Near oval window: narrow, thick

Near cochlear apex: wider, thinner

29
Q

Tectorial Membrane

A

Overhanging membrane of organ of corti

In contact with stereocilia of hair cells

30
Q

Role of Sense of Hearing

A

Translate pressure waves of perilymph and endolymph to electrical signal and acoustic sensation

31
Q

Bending of cilia produces change in K+ conductance

A

Toward kinocilium: increases K+ influx

Away from kinocilium: decreases K+ influx

Kinocilium = tallest sterocilia

32
Q

Basilar Membrane: Fibers

A

Span the width like the strings of a harp

Near oval window: short, stiff
-resonate with HIGH frequency waves

Near cochlear apex: longer, floppier
-resonate with lower frequency waves

33
Q

Sound

A

Pressure disturbance originated from a vibrating object

Propagated by molecules of medium (air, liquid)

Normally manifests as pressure or sound wave

34
Q

Frequency

A

Number of sound waves that pass a given point in a given time

Hertz

Shorter wavelength = high frequency

35
Q

Pitch

A

Our ears perceive different frequencies as pitch

higher frequency = higher pitch

ability to distinguish pitch and loudness depends on ability of cochlea to respond differently to vibrations of different amplitude and frequency

36
Q

Tuning Fork

A

Pure sound - single frequency

Most sounds are a mixture of frequencies

37
Q

Place Coding

A

Frequency sensitivity of IHCs depends on their position along basilar membrane of cochlea

38
Q

Loudness

A

An increase in AP firing

Related to amplitude of sound waves

Measure of sound intensity

Decibels

39
Q

Severe Hearing Loss

A

Frequent/prolonged exposure to sound greater than 90 dB

40
Q

Sound source directly in front, in back, over midline of head…

A

Intensity and timing cues will be the same for both ears

41
Q

Sound coming from one side…

A

Nearer hair cells activated:

  • slightly earlier
  • more vigorously
42
Q

Superior Olivary Nucleus

A

Functions in biaural hearing

Compares signals from R and L ear to identify direction from which a sound is coming

43
Q

Conductive Deafness

A

BC>AC

Sound vibrations don’t go from air to ossicles as well as they should (loss of air conduction)

Effects auditory canal and middle ear

44
Q

Conductive Deafness: Causes

A

Ear wax buildup
Fluid buildup from infection
Puncture of eardrum

45
Q

Conductive Deafness: Results

A

Loss of loudness
Loss of clarity
Sounds are weak, muffled, distorted

46
Q

Nerve Deafness

A

Sensorineuronal

Both air and bone conduction decreased

Auditory nerve damage (loss of air and bone conduction)

Effects cochlea, nerve, cochlear nucleus

47
Q

Nerve Deafness: Causes

A

Ototoxic drugs
Prolonged exposure to loud sounds
Inner ear infections

48
Q

Rinne Test

A

Use a tuning fork to determine air conduction (AC) and bone conduction (BC)

49
Q

Normal Hearing in Adults

A

0-25 dB

50
Q

Most Important Frequencies for Speech

A

250-6000 Hz

51
Q

Presbycusis

A

Gradual loss of hearing associated with aging

Due to gradual cumulative loss of hair cells and neurons

52
Q

Presbycusis: Loss

A

Loss of ability to hear consonants

Loss of high frequency sounds

Difficulty screening out background noise