4.8 Hypersensitivity Flashcards
What is meant by hypersensitivity?
Immune reaction that damages the body rather than protecting it from infection
What is the name of type I hypersensitivity?
Immediate/anaphylactic hypersensitivity
What are type I hypersensitivity reactions mediated by?
IgE antibodies
What is type I hypersensitivity triggered by?
Multivalent environmental antigens (allergens)
What 2 phases does type I hypersensitivity occur in?
Sensitisation
Re-exposure leading to anaphylaxis
Which 3 factors influence the initial sensitisation of the immune response to allergens?
Genetics, age, environment
Outline the sensitisation phase of type I hypersensitivity
APC present antigen and co-stimulatory molecule to T cell
Naive T cell becomes primed and differentiates into TH2 cell
TH2 cells release IL4 and 12 to promote class switching from IgM to IgE, and IL5 which activates eosinophils
IgE then bind FcE receptors on mast cells
Outline what happens in second exposure in type I hypersensitivity
Allergen binds to IgE on mast cells, crosslinking two IgE molecules
This causes rapid degranulation, releasing pro inflammatory mediators (histamines, cytokines, leukotrienes, prostaglandins)
What effects does histamine have?
Binds to H1 receptors
Causes bronchoconstriction, vasoconstriction, increased vascular permeability
What effects do leukotrienes have?
Smooth muscle contraction
Recruit neutro/eosinophils/mast cells after allergen is cleared
What happens if an allergen encounters cell bound IgE?
Rapid cross linking of IgE and degranulation of the mast cell
What happens in the early phase of type I hypersensitivity?
Effects of molecules released in mast cell degranulation
When does the early phase of type I hypersensitivity occur?
Few minutes after second exposure
What happens in the later phase of type I hypersensitivity?
Recruitment of neutrophils
When does the later phase of type I hypersensitivity occur?
Within a few hours
What happens in the late phase of type I hypersensitivity and when?
Eosinophils are recruited and TH2 cells are present
3-4 days after exposure
Which of an anaphylactic shock reaction or immune complex reaction requires more antigen to trigger?
Immune complex requires more antigen
List 3 treatments for type I hypersensitivity
Antihistamines – reduce bronchoconstriction and vascular permeability
Corticosteroids – decrease inflammatory response
Adrenaline – cause vasoconstriction
What causes anaphylactic shock?
Decrease in blood supply to vital organs (e.g. the brain) due to increased vascular permeability and increased airway constriction
What is the name of type II hypersensitivity?
Antibody mediated cytotoxic hypersensitivity
What does type II hypersensitivity involve?
The destruction of cells/tissue by IgG or IgM antibodies that bind to antigens present on the surface of normally healthy cells
What are examples of type II hypersensitivity reactions?
- Graves disease – antibodies bind to thyrotrophin receptor resulting in the over production of thyroid hormones
- Haemolytic disease of newborn – maternal antibodies can cross the placenta and destroy fetal red blood cells
- Immune thrombocytopenia – antibodies develop against platelets
What are the three mechanisms by which type II hypersensitivity reactions can occur?
- Anti-receptor activity
- Antibody dependant cell mediated cytotoxicity
- Classical activation of the complement cascade
Outline the first mechanism of complement activation in type II hypersensitivity
IgM/IgG binds an antigen that is bound to the surface of a healthy cell and activates complement
C1 binds Fc region of antibody and recruits other complement proteins
The proteins that are cleaved are chemotactic – attract neutrophils
Neutrophils degranulate and release enzymes that produce ROS, causing cell death